A5075291671- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Chemical synthesis and alkaloids
- Phytochemical compounds biological activities
- Alkaloids: synthesis and pharmacology
- Plant biochemistry and biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Advanced Computational Techniques and Applications
- Catalytic C–H Functionalization Methods
- Advanced Polymer Synthesis and Characterization
- Traditional Chinese Medicine Analysis
- Cholinesterase and Neurodegenerative Diseases
- Marine Sponges and Natural Products
- Biological and pharmacological studies of plants
- Bioactive natural compounds
- Plant-derived Lignans Synthesis and Bioactivity
- Bioactive Compounds and Antitumor Agents
- Advanced Sensor and Control Systems
- Heat shock proteins research
- Environmental and Agricultural Sciences
- biodegradable polymer synthesis and properties
- Computational Drug Discovery Methods
Yunnan University of Traditional Chinese Medicine
2019-2025
National Institutes of Health
2024
University of Chinese Academy of Sciences
2012-2023
Chongqing Institute of Green and Intelligent Technology
2023
Chongqing University
2023
Dalian Polytechnic University
2012-2022
Zaozhuang Municipal Hospital
2022
Yunnan University
2022
Zaozhuang University
2021
Chinese Academy of Sciences
2012-2020
Flexible positive pressure sensors have been studied extensively and used in a lot of scenarios. However, negative detection is also demand some scenarios, such as fluid mechanics analysis, air sensing, so on. wearable that can detect both pressures will greatly broaden the application field. In this paper, we report flexible highly sensitive ionic gel (IG) sensor, which simple low cost to prepare reliably large range from -98 100 kPa under an atmospheric about 982 hPa. The IG dielectric...
A short scalable biomimetic route to bioactive natural product bimagnolignan (1) was accomplished. Compound 1 successfully prepared through a three-step metal-free synthesis from honokiol (2). Alternatively, also synthesized by transformations that mimic tyrosinase in four steps. The key reactions feature regioselective acetylation, highly efficient C(sp2)–H oxidation, cascade aerobic oxidative cyclization/coupling, and Cu-catalyzed direct coupling. In addition, cell-based assays validate is...
A facile and straightforward method was developed to construct the fused tetracyclic 3-spirooxindole skeleton, which exists widely in natural products. The formation of structure achieved through a transition-metal-free intramolecular cross-dehydrogenative coupling pyridinium, were formed situ by condensation 3-(2-bromoethyl)indolin-2-one derivatives with 3-substituted pyridines. As examples application this new methodology, two potentially medicinal products, (±)-corynoxine B, efficiently...
With the continuous development of organic semiconductor materials and on-going improvement device technology, power conversion efficiencies (PCEs) solar cells (OSCs) have surpassed threshold 19%. Now, low production cost photovoltaic devices become an imperative demand for its practical application future commercialization. Herein, feasibility simplified synthesis cost-effective small-molecule acceptors via end-cap isomeric engineering is demonstrated, two constitutional isomers, BTP-m-4Cl...
New words such as names, technical terms, etc appear frequently.As such, the bilingual lexicon of a machine translation system has to be constantly updated with these new word translations.Comparable corpora news documents same period from different agencies are readily available.In this paper, we present approach mining translations comparable corpora, by using context information complement transliteration information.We evaluated our on six months Chinese and English Gigaword encouraging results.
Euphorbia peplus has been used in traditional medicine to treat asthma and psoriasis. Three highly modified diterpenoids, namely, pepluacetal (1) pepluanol A-B (2-3), have isolated identified from this plant. Compounds 1-3 exhibit unprecedented 5/4/7/3, 5/6/7/3, 5/5/8/3 ring systems, respectively. Their structures with absolute configurations were determined by spectroscopic analyses, X-ray crystallography, electronic circular dichroism calculations. Since Kv1.3 is a validated target for the...
Previously, vibsanin B (ViB) was found to preferentially target HSP90β compared HSP90α. In this study, multiple experiments, including pull-down assays of biotin-ViB with recombinant HSP90β-NTD, MD, CTD, and full-length HSP90β, molecular docking ViB its derivatives the HSP90 a inhibition assay interaction CTD GST-tagged cyclophilin 40 (Cyp40) by derivatives, suggest that can directly bind C-terminus. On basis predictions primary structure-activity relationships (SARs), series analogues...
Pepluanols C and D (1 2), featuring unprecedented 5/5/10 with out,out-[7.2.1]bicylcododecane core 6/6/7/3 fused-ring skeletons, respectively, were isolated from Euphorbia peplus. Their chemical structures absolute configurations determined by a series of extensive spectroscopic methods, X-ray diffraction analysis. In addition, pepluanols showed 31.6 ± 8.3% 30.5 2.8% peak current inhibition on the Kv1.3 potassium channel at 30 μM.
With the rapid advancement of urbanization, green space well-being (GSWB) developing countries faces drastic changes and is increasingly threatened. Green residential spaces are core elements GSWB; however, we know very little about interaction combination two in terms their effect on GSWB. This study identified spatiotemporal features GSWB critically examined how patterns residential-green combinations affect Based land-use data for Jinan from 2006 to 2018, using spatial measurement tool...
Alkyl salicylaldehyde derivatives are polyketide natural products, which widely distributed in fungi and exhibit great structural diversity. Their biosynthetic mechanisms have recently been intensively studied; however, how the synthases (PKSs) involved fungal alkyl biosyntheses release their products remained elusive. In this study, we discovered an orphan gene cluster of fungus Stachybotrys sp. g12. Intriguingly, highly reducing PKS StrA, encoded by cluster, performs a reductive chain...
Ginger is a rich source of ginger phenols with an anti-inflammatory property. Antineuroinflammatory pathways represent promising therapeutic strategy for neurodegenerative diseases. was selected as our research object to discover bioactive constituents responsible the antineuroinflammatory effect. An in silico-based reverse annotation strategy, conjunction molecular networking, employed large-scale from ginger. A total 174 and 235 phenol dimers were annotated. Five new (1-5) 18 known (6-23)...
Abstract Two concise and efficient synthetic routes were developed for the synthesis of three 1,7-diarylheptanoids ( 1 – 3 ) containing a 1,4-pentadiene unit, which originally isolated from Ottelia acuminata var. . The first approach focused on construction linear diarylheptanoids featuring (1 E ,4 )-pentadiene moiety, via Suzuki coupling reaction. second strategy enabled sixteen-membered macrocyclic ether 2 with Z unit. challenging macrocyclization was successfully accomplished through an...
A novel segetane diterpenoid (1) and four jatrophane diterpenoids (2–5) were isolated from an acetone extract of Euphorbia peplus. Due to quantity limitations, we prepared 1 via a Diels–Alder reaction, approach motivated by this compound's biosynthetic pathway successfully performed X-ray analysis 1. Furthermore, in vitro activity test, exhibited moderate anti-inflammatory activity, whereas both its precursor (2) the relevant intermediate (2a, IC50 = 1.56 μM) significant activity.
24 C3'-focused hybrids of aryl/penta-1,4-dien-3-one/amine (APDA) were designed and synthesized. Of these hybrids, 2 n demonstrated improved antiproliferative effects on HER2-positive breast cancer cells (SKBr3 BT474) triple-negative (TNBC) (MDA-MB-231 MDA-MB-468) with IC
ABSTRACT The first‐ and second‐generation well‐defined thermoresponsive amphiphilic linear–dendritic diblock copolymers based on hydrophilic linear poly( N ‐vinylcaprolactam) hydrophobic dendritic aromatic polyamide have been synthesized via reversible addition fragmentation chain transfer polymerization of ‐vinylcaprolactam by employing chain‐transfer agents possessing a single dithiocarbamate moiety at the focal point. These exhibit temperature‐dependent phase transition behaviors in...
The α,β-C(sp3)–H bond dual functionalization of tertiary amines is still a challenging task for both organic and medicinal chemists. Herein direct, mild, metal-free, site-specific method mediated by PIDA/I2 was developed amines, this can provide facile access to α-keto lactams or rarely studied α,α-diiodo lactams. Moreover, used the effective syntheses three natural products [obscurumine C (13), obscurumine O (17), strychnocarpine (18)] direct preparation mimics in vivo metabolites two...
Vibsatins A (1) and B (2), a pair of 14,15,16,17-tetranorvibsane-type diterpenoids that feature bicyclo[4.2.1]nonane moiety formed by new C-13/C-2 bond, were isolated from the twigs leaves Viburnum tinus cv. variegatus. The structures absolute configurations elucidated combination NMR spectra, optical rotation, X-ray diffraction experiments. possible biogenetic pathway is also proposed. Moreover, vibsatin enhanced neurite outgrowth NGF-mediated PC12 cells at concentration 10 μM.