ABSTRACT The first‐ and second‐generation well‐defined thermoresponsive amphiphilic linear–dendritic diblock copolymers based on hydrophilic linear poly( N ‐vinylcaprolactam) hydrophobic dendritic aromatic polyamide have been synthesized via reversible addition fragmentation chain transfer polymerization of ‐vinylcaprolactam by employing chain‐transfer agents possessing a single dithiocarbamate moiety at the focal point. These exhibit temperature‐dependent phase transition behaviors in...

In this study, we present the synthesis, self-assembly, and enzyme responsive nature of a unique class well-defined amphiphilic linear-dendritic block copolymers (PNVP-b-dendr(Phe-Lys)n, n = 1–3) based on linear poly(N-vinylpyrrolidone) (PNVP) dendritic phenylalanyl-lysine (Phe-Lys) dipeptides. The were prepared via combination ofreversible addition-fragmentation chain transfer (RAFT)/xanthates (MADIX) polymerization N-vinylpyrrolidone stepwise peptide chemistry. results fluorescence...

The thermosensitive and hydrolytic properties biocompatibility of polyphosphazenes containing lactic acid ester methoxyethoxyethoxy as co-substitutents were investigated. Depending on the type ester, these exhibited lower critical solution temperatures (LCST) (from 33 to 52 °C), which almost concentration-independent in range 1.5 15 wt% polymers aqueous solution. salt effect thermosensitivity was studied by measuring their LCST solutions various salts. Bu 4 NBr KI showed salting-in effects...

Abstract A new biodegradable polyphosphazene (PYRMP) containing N ‐ethoxypyrrolidone and methoxyethoxyethoxy side groups was synthesized via a route of macromolecular substitution. The synthetic method poly{bis[2‐(2‐oxo‐1‐pyrrolidinyl)ethoxy]phosphazene} (PYRP) improved. thermal properties the polymers were investigated using differential scanning calorimetry. Degradation studies carried out in vitro with varying pH conditions. cytotoxicity PYRMP its hydrolysis products evaluated methyl...

Phe–Lys dipeptide-linked amphiphilic LDBCs with ketal peripheries can serve as enzyme and pH dual responsive drug carriers excellent biocompatibility.

Abstract Four novel dihydroisocoumarin (=3,4‐dihydro‐1 H ‐2‐benzopyran‐1‐one) glucosides were isolated from a culture broth of strain the fungus Cephalosporium sp. AL031. Their structures elucidated as (2 E ,4 )‐5‐[(3 S )‐5‐acetyl‐8‐( β ‐ D ‐glucopyranosyloxy)‐3,4‐dihydro‐6‐hydroxy‐1‐oxo‐1 ‐2‐benzopyran‐3‐yl]penta‐2,4‐dienal ( 1 ), ‐glucopyranosyloxy)‐3,4‐dihydro‐6‐methoxy‐1‐oxo‐1 2 (3 )‐8‐( ‐glucopyranosyloxy)‐3‐[(1 ,3 ,5 )‐hepta‐1,3,5‐trienyl]‐3,4‐dihydro‐6‐hydroxy‐5‐methyl‐1...

Abstract A novel thermosensitive second-generation poly(benzyl ether) dendron with oligoethyleneoxy chains at the periphery was synthesized. Its cloud point (CP) decreased an increasing concentration over a range of concentrations from 9 to 60 wt %. Fluorescent spectroscopy and AFM studies revealed that self-assembled into spherical micelles, about 50 nm in diameter, its CMC aqueous solution. This has potential as smart materials.

A new third-generation thermoresponsive amphiphilic dendron consisting of a hydrophobic poly(benzyl ether) dendritic core and hydrophilic oligo(ethylene glycol) peripheries was synthesized by an efficient convergent approach. Its structure confirmed 1 H NMR, 13 C IR, GPC, MALDI-TOF MS, elemental analysis. Turbidity dynamic light scattering (DLS) measurements demonstrated that the showed reversible temperature-dependent phase-transition behavior in aqueous solution its lower critical...

New amphiphilic linear-dendritic diblock copolymers based on poly[<italic>N</italic>-(2-hydroxyethyl-<sc>l</sc>-glutamine)] have been synthesized, and their micellar assemblies can disassemble release encapsulated molecular cargo upon enzymatic activation.

Abstract In this study, two linear poly( N ‐vinylcaprolactam)s (PNVCLs) with different molecular weights were first synthesized as polymeric supporters by reversible addition‐fragmentation chain transfer polymerization and then used to prepare cathepsin B thermal dual‐stimuli responsive amphiphilic linear–dendritic block copolymers (LDBCs) PNVCL n ‐ b d (Phe‐Lys) 1–3 ( = 66, 100) dendritic phenylalanyl‐lysine dipeptides via stepwise peptide chemistry. The characterized 1 H NMR spectra gel...

ABSTRACT Four generations of new amphiphilic thermoresponsive linear‐dendritic block copolymers (LDBCs) with a linear poly( N ‐vinylcaprolactam) (PNVCL) and dendritic poly(benzyl ether) are synthesized by atom transfer radical polymerization (ATRP) ‐vinylcaprolactam (NVCL) using chlorides as initiators. The have been characterized 1 H NMR, FTIR, GPC showing controlled molecular weight narrow distribution (PDI ≤ 1.25). Their self‐organization in aqueous media property highly dependent on the...

This study describes the synthesis and solution properties of novel linear–dendritic block copolymers (LDBCs) based on thermoresponsive poly(<italic>N</italic>-vinylcaprolactam) (PNVCL) chains pH-responsive poly(benzyl ether) dendrons.

Two new dihydroisocoumarins, 3,4-dihydro-3-heptantrienyl-8-hydroxyl-6-hydroxymethyl-5-methylisocoumarin and 6-acetoxymethylene-3,4-dihydro-3-heptantrienyl-8-hydroxyl-5-methylisocoumarin were isolated from a culture broth of strain the fungus, Cephalosporium sp. AL031. Their structures elucidated by interpretation their spectroscopic data.

The first‐ and second‐generation well‐defined thermal enzymatic dual‐stimuli responsive amphiphilic linear‐dendritic block copolymers (LDBCs) based on hydrophilic linear poly( N ‐vinylcaprolactam) (PNVCL) a hydrophobic Fmoc‐terminated dendron derived from an aliphatic polyester of 2, 2′‐dimethylolpropionic acid (bis‐MPA) have been synthesized via combination reversible addition fragmentation chain transfer (RAFT) polymerization ‐vinylcaprolactam (NVCL) “chain‐first” strategy. were...

Abstract New biodegradable polyphosphazenes containing lactic acid ester side groups were synthesized via a route of macromolecular substitution. Their biodegradability and biocompatibility studied in vitro. The polymers showed the fastest hydrolysis basic solution, followed by acidic then neutral solution. rate these polymers' degradation decreased order poly[bis(ethyl lactato)phosphazene] > poly[bis(propyl poly[bis(butyl lactato)phosphazene]. possible pathways discussed. MTT assays...