A5021046198- Pancreatic function and diabetes
- Drug Solubulity and Delivery Systems
- Reproductive System and Pregnancy
- Birth, Development, and Health
- DNA Repair Mechanisms
- Mitochondrial Function and Pathology
- Fibroblast Growth Factor Research
- Retinoids in leukemia and cellular processes
- Advanced Drug Delivery Systems
- Nuclear Receptors and Signaling
- Pregnancy and preeclampsia studies
- Carcinogens and Genotoxicity Assessment
- Estrogen and related hormone effects
- Drug Transport and Resistance Mechanisms
- Epigenetics and DNA Methylation
- Endometriosis Research and Treatment
- Protein purification and stability
- interferon and immune responses
- Immune Cell Function and Interaction
- Metabolism, Diabetes, and Cancer
- Per- and polyfluoroalkyl substances research
- Cystic Fibrosis Research Advances
- Berberine and alkaloids research
- Asthma and respiratory diseases
- Aldose Reductase and Taurine
St. John's University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2005-2024
Rosalind Franklin University of Medicine and Science
2020-2022
Queens College, CUNY
2019
University of Utah
2018
Feinstein Institute for Medical Research
2018
University of Illinois Chicago
2018
Institute for Reproductive Health
2012-2017
University of Kansas Medical Center
2004-2017
University of Kansas
2012
Pregnane X receptor (PXR) mediates xenobiotic and endobiotic metabolism as well hepatocyte proliferation. To determine the role of PXR in liver regeneration, 2/3 partial hepatectomy (PH) was performed on wild-type PXR-null mice. Our results showed that hepatic steatosis markedly suppressed mice lacking 36 hours after PH, concomitant with reduction proliferation at same time point. Gene expression analysis revealed regulating transcription genes involved lipid uptake, transport, biosynthesis,...
Regulation of mitochondrial biogenesis and respiration is a complex process that involves several signaling pathways transcription factors as well communication between the nuclear genomes. Under aerobic conditions, budding yeast Saccharomyces cerevisiae metabolizes glucose predominantly by glycolysis fermentation. We have recently shown altered chromatin structure in induces mechanism requires transport metabolism pyruvate mitochondria. However, how controls transcriptional responses...
// Meina Xie 1, 2 , Pengli Bu 3, 4 Fengjie Li 1 Shijian Lan Hongjuan Wu 5 Lu Yuan Ying Wang Medicine Experiment Center, Weifang Medical University, Wei Fang 261053, P. R. China School of Bioscience and Technology, 3 Department Biological Sciences, St. John's Queens, NY 11439, USA Pharmaceutical Basic Correspondence to: Xie, e-mail: wfmcxiemeina@163.com Keywords: bisphenol A, spermatogenic cells, meiotic arrest, Boule, estrogen receptor α/β Received: October 13, 2015 Accepted: January 18,...
Caspases are cysteine proteases that play a central role in the execution of apoptosis. Recent evidence indicates caspase-2 is activated early response to genotoxic stress and can function as an upstream modulator mitochondrial apoptotic pathway. In particular, we have shown previously fully processed permeabilize outer membrane cause cytochrome c Smac/DIABLO release from these organelles. Using permeabilized cells, isolated mitochondria, protein-free liposomes, now report this effect direct...
The proto-oncogene Bcl3 induces survival and proliferation in cancer cells; however, its function regulation ovarian (OC) remain unknown. Here, we show that expression is increased human OC tissues. Surprisingly, found addition to promoting survival, proliferation, migration of cells, promotes both constitutive interferon-γ (IFN)-induced the immune checkpoint molecule PD-L1. cells further by IFN, resulting PD-L1 transcription. mechanism consists an IFN-induced, Bcl3- p300-dependent promoter...
Overexpression of the pro-angiogenic chemokine IL-8 (CXCL8) is associated with a poor prognosis in several solid tumors, including epithelial ovarian cancer (EOC). Even though histone deacetylase (HDAC) inhibition has shown remarkable antitumor activity hematological malignancies, it been less effective EOC. Here we report results that may explain decreased efficiency HDAC EOC, based on our data demonstrating specifically induces expression IL-8/CXCL8 SKOV3, CAOV3, and OVCAR3 cells....
Early pregnancy loss is common and can be caused by a range of factors. The Brown Norway (BN) rat exhibits reproductive dysfunction characterized small litter size failure represents model for investigating early loss. In this study, we investigated the establishment in BN gained insight into mechanisms causing its subfertility. stages uteroplacental organization are unique. primordial placenta restricted development correlates with limited uterine decidual development. decidua was shown to...
The prolactin (PRL) family of hormones and cytokines participates in the regulation optimal reproductive performance mouse rat. Members PRL are expressed anterior pituitary, uterus, and/or placenta. In present study, we investigated ontogeny 7, subfamily b, member 1 (PRL7B1; also called PRL-like protein-N, PLP-N) expression developing placenta established a model for investigating biological function PRL7B1. Transcripts Prl7b1 were first detected on Gestation Day (d) 8.5. From gestation d8.5...
The uterine endometrium uniquely regenerates after menses, postpartum, or breaks in the layer integrity throughout women's lives. Direct cell-cell contacts ensured by tight and adherens junctions play an important role endometrial integrity. Any changes these can alter permeability of uterus have impact on regeneration layers. Interleukin 22 (IL-22) is a cytokine that recognized for its epithelial regeneration. Moreover, it crucial controlling inflammatory response mucosal tissues. Here, we...
Retinoids are used to treat several types of cancer; however, their effects on liver cancer have not been fully characterized. To investigate the therapeutic potential retinoids hepatocellular carcinoma (HCC), present study evaluates apoptotic effect a panel natural and synthetic in three human HCC cell lines as well explores underlying mechanisms. Apoptosis was determined by caspase-3 cleavage using western blot, DNA double-strand breaks TUNEL assay, phosphatidylserine translocation flow...
Glucose transporter (Glut) 9 plays an important role in maintaining the homeostasis of uric acid body. Although physiologic functions Glut9 have been well established, regulation expression is less understood. In this study, we showed that mRNA and protein mouse liver kidney are female predominant. Ontogeny studies further revealed female-predominant only occurs adult mice, which primarily attributable to fact sustains females but gradually decreases males after it reaches peak level at day...
Abstract Epalrestat (EPS), an aldose reductase inhibitor, is widely prescribed to manage diabetic neuropathy. It generally believed that EPS beneficial patients because it can protect endothelial cells, Schwann or other neural cells from oxidative stress. However, several clinical studies revealed therapy led liver dysfunction, which limited its applications. Currently, the underlying mechanism by causes dysfunction unknown. This study aimed investigate responsible for EPS-induced injury. In...
The prolactin (PRL) family of hormones/cytokines participates in the regulation reproduction. Mouse mutagenesis has been used to characterize biology a subset PRL ligands. To date, members have implicated female In this study, we mouse investigate 3, subfamily c, member 1 (PRL3C1), heparin binding decidual cell cytokine previously establishment pregnancy. Male and mice possessing Prl3c1 null mutant allele on C57BL/6 genetic background exhibited severe subfertility. Moving mutation mixed...
Mammals share common strategies for regulating reproduction, including a conserved hypothalamic-pituitary-gonadal axis; yet, individual species exhibit differences in reproductive performance. In this report, we describe the discovery of species-restricted homeostatic control system programming testis growth and function. Prl3c1 is member prolactin gene family its protein product (PLP-J) was discovered as uterine cytokine contributing to establishment pregnancy. We utilized mouse mutagenesis...