A5036116332- Retinoids in leukemia and cellular processes
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Estrogen and related hormone effects
- Pharmacogenetics and Drug Metabolism
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Reproductive System and Pregnancy
- Diet, Metabolism, and Disease
- Neurotransmitter Receptor Influence on Behavior
- Psoriasis: Treatment and Pathogenesis
- Cholesterol and Lipid Metabolism
- interferon and immune responses
- Reproductive Biology and Fertility
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Dermatology and Skin Diseases
- Eicosanoids and Hypertension Pharmacology
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Glycosylation and Glycoproteins Research
University of California, Davis
2014-2025
University of California Davis Medical Center
2015-2024
University of California System
2022
Southern Medical University
2020
University Gastroenterology
2016
Shanghai University
2015
Guangzhou Medical University
2009-2014
Guangzhou First People's Hospital
2009-2014
Guangzhou Center for Disease Control and Prevention
2014
Shanghai University of Traditional Chinese Medicine
2014
A large number of physiological processes in the adult liver are regulated by nuclear receptors that require heterodimerization with retinoid X (RXRs).In this study, we have used cre-mediated recombination to disrupt mouse RXR␣ gene specifically hepatocytes.Although such mice viable, molecular and biochemical parameters indicate every one examined metabolic pathways (mediated RXR PPAR␣, CAR, PXR, LXR, FXR) is compromised absence RXR␣.These data demonstrate presence a complex circuitry which...
AIM:To investigate Fusobacterium nucleatum (F.nucleatum ) abundance in colorectal cancer (CRC) tissues and its association with CRC invasiveness Chinese patients. METHODS:The resected adjacent normal (10 cm beyond margins) from 101 consecutive patients were collected.Fluorescent quantitative polymerase chain reaction (FQ-PCR) was applied to detect F. tissues.The difference of between the relationship clinical variables evaluated.Fluorescence situ hybridization (FISH) analysis performed on 22...
This study aims to uncover how specific bacteria and bile acids (BAs) contribute steatosis induced by diet farnesoid X receptor (FXR) deficiency in both genders. A control (CD) Western (WD), which contains high fat carbohydrate, were used feed wild type (WT) FXR knockout (KO) mice followed phenotyping characterization as well BA microbiota profiling. Our data revealed that male WD-fed KO had the most severe highest hepatic serum lipids insulin resistance among eight studied groups. Gender...
Dysregulated bile acid (BA) synthesis or reduced farnesoid X receptor (FXR) levels are found in patients having metabolic diseases, autoimmune hepatitis, and liver cirrhosis cancer. The objective of this study was to establish the relationship between butyrate dysregulated BA synthesis-induced hepatitis as well effect reversing pathology. Wild-type (WT) FXR knockout (KO) male mice were placed on a control (CD) western diet (WD) for 15 months. In presence absence supplementation, feces...
The goal of this study was to identify the intrinsic links that explain effect a Western diet (WD) on cognitive dysfunction. Specific pathogen-free, wild-type mice were fed either control (CD) or high-fat, high-sucrose WD after weaning and euthanized at 10 mo age pathways affect health. results showed long-term intake reduced hippocampal synaptic plasticity level brain-derived neurotrophic factor mRNA in brain isolated microglia. A also activated ERK1/2 postsynaptic density-95 brain,...
ABSTRACT Dysregulated bile acid (BA) synthesis is accompanied by dysbiosis, leading to compromised metabolism. This study analyzes the effect of epigallocatechin‐3‐gallate (EGCG) on diet‐induced obesity through regulation BA signaling and gut microbiota. The data revealed that EGCG effectively reduced diet‐increased obesity, visceral fat, insulin resistance. Gene profiling showed had a significant impact regulating genes implicated in fatty uptake, adipogenesis, metabolism adipose tissue. In...
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and immune effects, including retinoic acids, bile vitamin D3, short-chain fatty acids. The tumor suppressor effects of miR-22 been suggested, but whether treats orthotopic hepatocellular carcinoma (HCC) is not established. role in regulating immunity also poorly understood. Our data showed delivered adeno-associated virus serotype 8 effectively treated HCC. Compared with FDA-approved lenvatinib, produced...
Abstract Background The treatment options for hepatocellular carcinoma (HCC) are limited, and there is no effective drug that can improve long-term survival rates. Complicated cocktails consisting of multiple medications with toxicities frequently used to treat cancer. current study addresses these challenges. Methods uses metabolic dysfunction-associated steatohepatitis (MASH)-HCC HCC mouse models established by transfecting the livers using myr-AKT1, NRasV12, Sleeping Beauty transposase....
This study was done to determine if a relationship exists between CYP2E1 induction by ethanol, lipid peroxidation, and liver pathology in experimental alcohol-induced disease the rat. Rats were fed ethanol with or without diallyl sulfide (DAS) phenethyl isothiocyanate (PIC) intragastrically for 1 month. correlated microsomal hydroxylation of paranitrophenol, score using data from PIC-fed rats. Some DAS-fed rats not included here because they have been reported elsewhere. Microsomal protein...
Identification of genetic variation predictive clearance rate a wide variety prescription drugs could lead to cost-effective personalized medicine. Here we identify regulatory genes whose variable expression level among individuals may have widespread effects upon drugs. Twenty liver samples with CYP3A activity were profiled for and xenobiotic metabolism as well involved in the regulation thereof. Regulatory accounted highest degree collinearity levels identified possible master regulators...
The nuclear receptor liver X receptor-α (LXRα) stimulates lipogenesis, leading to steatosis. Nuclear factor erythroid-2-related factor-2 (Nrf2) contributes cellular defense mechanism by upregulating antioxidant genes, and may protect the from injury inflicted fat accumulation. However, whether Nrf2 affects LXRα activity is unknown. This study investigated inhibitory role of in hepatic molecular basis.A deficiency enhanced ability agonist promote steatosis, as mediated lipogenic gene...
Pregnane X receptor (PXR) mediates xenobiotic and endobiotic metabolism as well hepatocyte proliferation. To determine the role of PXR in liver regeneration, 2/3 partial hepatectomy (PH) was performed on wild-type PXR-null mice. Our results showed that hepatic steatosis markedly suppressed mice lacking 36 hours after PH, concomitant with reduction proliferation at same time point. Gene expression analysis revealed regulating transcription genes involved lipid uptake, transport, biosynthesis,...
Long-term consumption of a diet with excessive fat and sucrose (Western diet, WD) leads to an elevated risk obesity metabolic syndrome in both males females. However, there are sexual dimorphisms metabolism which apparent when considering the prevalence complications syndrome, such as non-alcoholic fatty liver disease. This study aimed elucidate impact WD on metabolome gut microbiota male female mice at 5, 10, 15 months capture dynamic comprehensive changes brought about by different stages...