A5100369417- Prenatal Screening and Diagnostics
- Cystic Fibrosis Research Advances
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and preeclampsia studies
- Sperm and Testicular Function
- Pregnancy-related medical research
- Diabetes Management and Education
- Gestational Diabetes Research and Management
- RNA Research and Splicing
- Sexual Differentiation and Disorders
- Hemoglobinopathies and Related Disorders
- Seed Germination and Physiology
- Advanced Biosensing Techniques and Applications
- Cardiovascular Health and Risk Factors
- Congenital Diaphragmatic Hernia Studies
- Malaria Research and Control
- Infant Development and Preterm Care
- Parvovirus B19 Infection Studies
- Mosquito-borne diseases and control
- Health Promotion and Cardiovascular Prevention
Jinan University
2025
Nanjing Maternity and Child Health Care Hospital
2014-2025
Nanjing Medical University
2014-2025
Affiliated Hospital of Jining Medical University
2024
Women's Hospital
2024
Tongren Hospital
2017
Xijing Hospital
2016
Air Force Medical University
2016
Objective Cell-free DNA (cfDNA) screening for aneuploidy was clinically introduced in 2011. We aim to focus on the follow-up information from a single tertiary center undergoing genome-wide cfDNA evaluate this technology. Method A total of 32 431 cases were retrospectively reviewed. The performed using BGI protocol, and results analyzed together with pregnancy outcomes, confirmatory testing results, ultrasound findings. Results Of cases, successful conducted 287 (82.2%) high-risk 85 (94.4%)...
Abstract Here, we aimed to validate a noninvasive method using capture sequencing for prenatal diagnosis of congenital adrenal hyperplasia due 21-Hydroxylase deficiency (21-OHD). Noninvasive (NIPD) 21-OHD was based on 14 plasma samples collected from 12 families, including four sample during the first trimester. Targeted performed genomic DNA parents and child trios determine pathogenic wild-type alleles associated with haplotypes. Maternal also sequenced fetal inheritance allele hidden...
Abstract Background Ornithine transcarbamylase deficiency exhibits a high degree of clinical heterogeneity, making its screening and classification challenging in some instances. In this study, we first established simple stable method for testing ornithine activity using micro blood from newborns, rather than relying on venous blood. Methods The was assessed by measuring the concentration citrulline produced reaction with carbamoyl phosphate ornithine, serum, plasma or Correlation analysis...
Serine proteases are involved in many physiological activities as initiators of proteolytic cascades, and some members have been reported to play roles male reproduction. Transmembrane serine protease 12 (TMPRSS12) has shown regulate sperm motility uterotubal junction migration mice, but its role the testis remains unknown. In this study, we verified that TMPRSS12 was expressed spermatocytes spermatids acrosome sperm. Mice deficient Tmprss12 exhibited sterility. meiosis, demonstrated...
Background Pre-pregnancy overweight and obesity are negatively associated with delayed onset of lactogenesis II (OL), but the mechanisms by which these conditions affect OL still unclear. Objectives To identify biological factors related to pre-pregnancy overweight/obesity determine whether were in this population. Methods In prospective observational study, we assigned 72 primipara a overweight/obese group ( n = 36) normal-weight 36). Blood samples collected at 37 w gestation 48 h...
This study aims to understand the current situation and multiple factors affecting core competence specializing in maternal, neonatal under-five nursing China.Highly skilled nurses midwives are essential worldwide for achieving Sustainable Development Goals, especially low- middle-income countries like China, due overwhelming COVID-19 crisis.The 890 from 12 hospitals were investigated this cross-sectional study, with two questionnaires: sociodemographic information competency inventory...
Expanded carrier screening, a type of reproductive genetic testing for couples, has gained tremendous popularity assessing the risk passing on certain conditions to offspring. Here, screening assay 448 pathogenic variants was developed using capillary electrophoresis-based multiplex PCR technology. The achieved sensitivity, specificity, and accuracy 97.4%, 100%, 99.6%, respectively, in detecting specific variants. Among 1915 couples (3830 individuals), 708 individuals (18.5%) were identified...
Rationale: The use of musculoskeletal ultrasound (MU) method in the diagnosis shoulder pain and injury guidance injection blocking has been established. However, treatment posthemiplegic (HSP) with MU-guided precise physical therapy not reported. Patient concerns: Here, we present first case report a 64-year-old man right basal ganglia hemorrhage. Left side remained unbearable, which seriously affected sleep shoulder-related activities. Interventions: patient received drug administration,...
Objects: To investigate the effect of health management on Chinese elderly. Methods:600 individuals who aged 60 and older in Nanjing, China were randomly allocated into intervention control group. Results: after 6 month group elderly improved a lot main indexes literacy - knowledge, behavior, belief skills. As for services utilization, hospitalization days reduced between two groups had significant difference; times outpatient last months was more than group, but difference not statistically...
Abstract Background the mortality associated with severe malaria due to Plasmodiun falciparum remains high despite improvements in management. Case prensentation: this case series aims describe efficacy and safety of exchange transfusion combined artesunate (ET-AS) regimen P. malaria. Eight patients diagnosed were included. All underwent ET using COBE Spectra system. The aimed for a post-exchange hematocrit 30%. Half estimated blood volume was removed replaced fresh frozen plasma....
Expanded carrier screening (ECS) is a preventive genetic test that enables couples to know their risk of having child affected by certain monogenetic diseases. This study aimed evaluate the frequency for rare monogenic diseases in general Chinese population and impacts ECS on reproductive decisions pregnancy outcomes.
Abstract Background Thalassemia is a common genetic disorder in southwestern China, and an increasing number of cases from eastern China have been recently reported. Here, we developed rapid, convenient, accurate assay to evaluate the mutation spectrum thalassemia China. Methods A carrier screening for 61 hotspot variants among HBA1/HBA2 HBB (OMIM: 141800, 141850, 141900) genes was by SNaPshot/high‐throughput ligation‐dependent probe amplification (HLPA) technology. We used this detect...
<title>Abstract</title> Preterm delivery (PTD) leads to severe adverse maternal and neonatal outcomes larger medical costs. Thus, PTD deserves more attention. However, how predict is a problem that bothers researcher. This study aimed investigate potential prenatal predictors of PTD. We retrospectively recruited pregnant women who experienced either or term (TD) underwent laboratory examinations at 32 weeks gestation. compared the test results between two groups performed logistic regression...