A5049397619- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Chronic Lymphocytic Leukemia Research
- Mesenchymal stem cell research
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Polyomavirus and related diseases
- T-cell and B-cell Immunology
- COVID-19 and healthcare impacts
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- Autoimmune Bullous Skin Diseases
- Multiple Myeloma Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- PI3K/AKT/mTOR signaling in cancer
- COVID-19 diagnosis using AI
- Cytomegalovirus and herpesvirus research
Army Medical University
2016-2025
Xinqiao Hospital
2016-2025
China Agricultural University
2023-2025
State Key Laboratory of Animal Nutrition
2025
Sichuan Agricultural University
2024
Dalian Medical University
2018-2023
Chongqing Medical University
2018-2023
Second Affiliated Hospital of Chongqing Medical University
2018-2023
State Council of the People's Republic of China
2019-2020
Beckman Research Institute
2018
Alginate oligosaccharide (AOS) holds great potential as a novel feed supplement in farm animals. However, the effects of AOS on chicken health and underlying mechanisms are not fully understood. This study aimed to optimize enzymatic preparation by using bacterial alginate lyases expressed yeast, investigate prepared growth performance gut broiler chickens, reveal mechanisms.Five from bacteria were cloned into Pichia pastoris GS115 lyase PDE9 was at relatively high yield, activity stability...
T-cell acute lymphoblastic leukemia (T-ALL) with coexisting SIL-TAL1 fusion and t(11;14)(p15;q11.2) is exceedingly rare. There are limited data on the clinical course outcomes of such patients. We report a case 19-year-old male presenting aggressive T-ALL harboring these abnormalities, along NOTCH1 PTEN mutations. positivity associated poor prognosis in T-ALL. Despite achieving remission intensive chemotherapy, patient experienced rapid relapse overall survival, reflecting ineffectiveness...
Immune thrombocytopenia (ITP) is an autoimmune disease which arises due to self-destruction of circulating platelets. Failure respond or maintain a response first-line treatment can lead refractory/relapsed (R/R) ITP. The mechanism remains complicated and lacks standard clinical treatment. Sirolimus (SRL) mammalian target rapamycin (mTOR) inhibitor that has been demonstrated inhibit lymphocyte activity, indicating potential for SRL in Activation the mTOR pathway diseases suggests might be...
To compare the outcomes of patients with hematological malignancies who received ATG-Fresenius (ATG-F) 20 mg/kg versus those ATG-Genzyme (ATG-G) 10 in an unrelated donor hematopoietic stem cell transplantation (HSCT) procedure, a total 186 underwent their first allogeneic HSCT were retrospectively analyzed. One hundred and seven ATG-F, seventy-nine ATG-G. Multivariate analysis showed that type ATG preparation had no effect on neutrophil engraftment (P = 0.61), cumulative incidence relapse...
Abstract Background The novel coronavirus disease 2019 (COVID-19) spreads rapidly among people and causes a pandemic. It is of great clinical significance to identify COVID-19 patients with high risk death. Methods A total 2169 adult were enrolled from Wuhan, China, February 10th April 15th, 2020. Difference analyses medical records performed between severe non-severe groups, as well survivors non-survivors. In addition, we developed decision tree model predict death outcome in patients....
Clinical question What are the recommendations for timing, dosage, and usage of corticosteroids during cytokine release syndrome (CRS) caused by chimeric antigen receptor (CAR)-T cell therapy hematologic malignancies? Recommendations The administration in CRS should be managed depending on risk stratification grading occurrence, combined with clinical situation, dynamic assessments CAR-T kinetics level changes [Table 1]. Table 1 - management patients receiving therapy. Grades Standard-risk...
Abstract: The chronic myeloid leukemia (CML) is easily diagnosed by laboratory examination, however, rare BCR-ABL1 mRNA transcripts variants, such as e1a3 present diagnosis and therapeutic challenges. This case report details the management of a CML patient with transcript FISH RT-PCR. Following initial diagnosis, was treated tyrosine kinase inhibitor (TKI) Flumatinib. During treatment, although FCM-MRD bone marrow kept negative, expression detected PCR always remained positive. After...
At the end of 2022, COVID-19 wreaked havoc in China as well around world. Here, we focused on dynamic changes platelet kinetics and psychological state ITP patients before after infection with COVID-19. A questionnaire survey was designed to retrospectively investigate COVID-19-related symptoms, count, infected Omicron variant during November 2022 January 2023, a healthy population conducted control. total 90 69 individuals were included study. The results showed that only terms low-grade...
PURPOSE The aim of this open-label, multicenter, randomized controlled trial was to determine the efficacy and safety sequential umbilical cord–derived mesenchymal stem cell (UC-MSC) infusion for graft-versus-host disease (GVHD) prevention within 3 months haploidentical hematopoietic transplantation (haplo-HSCT). METHODS This open-label study evaluated UC-MSC (administer 1 × 10 6 /kg 4 hours before commencement day 0, once weekly first month after transplantation, every 2 weeks second month,...
Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is the only curative strategy for patients with chronic myelomonocytic leukemia (CMML). However, few reports have investigated outcomes of receiving haploidentical HSCT. To this end, we included 117 donors (HID) and 75 matched related (MRD) from 28 centers across China to explore prognostic impact different modalities. We found no significant difference between these two groups in terms event‐free survival (EFS, p = .211),...
BACKGROUNDCytokine biomarkers have already been used to predict acute graft-versus-host disease (aGVHD) onset, nonrelapse mortality, and overall survival in human mouse models, but the consistency of consequences between patients mice has not evaluated. Furthermore, no study about any biomarker or panel for aGVHD grading steroid sensitivity simultaneously reported.METHODSHere we established an model explored relation onset variations some cytokines. Based on results latest progress, selected...
It is well documented that COVID-19 vaccines greatly reduce the severity and complications of SARS-CoV-2 infection. However, it has been reported related may induce or exacerbate autoimmune hematological disorders, for example, a decrease in platelet numbers characteristic immune thrombocytopenia (ITP). To investigate this, we retrospectively reported, first time, clinical characteristics 42 ITP patients after vaccination southwest China. Of patients, 28 were historically diagnosed ITP,...
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic transplantation (allo-HSCT) the only curable treatment. The outcomes after transplant are influenced by both disease characteristics patient comorbidities. To develop novel prognostic model to predict post-transplant survival of CMML patients, we identified risk factors applying univariable multivariable Cox proportional hazards regression derivation cohort. In analysis, advanced age (hazard...
Our previous study demonstrated that human umbilical cord blood-derived stromal cells (hUCBDSCs) support the growth of hematopoietic stem cells, and promote expansion colony-forming units megakaryocyte (CFU-Mk) even more efficiently than bone marrow (hBMSCs). Given unique role hUCBDSCs in megakaryocytopoiesis vitro, this follow up study, we further investigated their effects vivo on hematopoiesis setting cell (HSC) transplants. After infusing alone or together with either hBMSCs into...