A5103243204- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- COVID-19 diagnosis using AI
- Healthcare cost, quality, practices
- Long-Term Effects of COVID-19
- Ferroptosis and cancer prognosis
- COVID-19 and healthcare impacts
- Magnetic Bearings and Levitation Dynamics
- Electric Motor Design and Analysis
- Grouting, Rheology, and Soil Mechanics
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- PARP inhibition in cancer therapy
- Neuroendocrine Tumor Research Advances
- Head and Neck Cancer Studies
- Peptidase Inhibition and Analysis
- Oral health in cancer treatment
- SARS-CoV-2 and COVID-19 Research
- Soil and Unsaturated Flow
- Cancer-related gene regulation
Xinqiao Hospital
2020-2025
Army Medical University
2021-2025
Ningbo University
2023-2024
Xi'an University of Science and Technology
2022-2024
Ningbo Institute of Industrial Technology
2023
Chinese Academy of Sciences
2023
Army Medical College
2022
Xuchang University
2022
State Key Laboratory of Rice Biology
2019
Zhejiang University
2019
Abstract Background The novel coronavirus disease 2019 (COVID-19) spreads rapidly among people and causes a pandemic. It is of great clinical significance to identify COVID-19 patients with high risk death. Methods A total 2169 adult were enrolled from Wuhan, China, February 10th April 15th, 2020. Difference analyses medical records performed between severe non-severe groups, as well survivors non-survivors. In addition, we developed decision tree model predict death outcome in patients....
Immune checkpoint inhibitors (ICIs) bring cancer patients tumor control and survival benefits, yet they also trigger immune-related adverse effects (irAEs), notably inhibitor-related pneumonitis (CIP), affecting about 5% of among whom 1–2% experiencing severe grade 3 or higher pneumonitis. Current research points to potential links with T cell subset dysfunction autoantibody increase, but the specific mechanisms underlying different grades CIP are understudied. Herein, we employed...
Non-small cell lung cancer (NSCLC) with liver metastasis carries a poor prognosis, and evidence for optimal treatment strategies remains limited. The combination of radiotherapy (RT) immunochemotherapy has shown promise in improving survival outcomes patients advanced NSCLC, however, large cohort studies targeting NSCLC are lacking. purpose this study was to analyze the impact RT combined on long-term leveraging data from Surveillance, Epidemiology, End Results Program (SEER) database...
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors as it was submitted and made public without consent all authors. Therefore, do not wish work to be cited a reference. Questions should directed corresponding author.
Abstract Background Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. Methods From February 10th April 15th, 2020, 103 were enrolled. Difference analyses performed between severe non-severe patients. A propensity score matching (PSM) analysis was performed, including 206 matched non-cancer Next, we identified factors developed a nomogram...
This randomized controlled phase II study investigated the efficacy, safety and underlying mechanism of maxillofacial oral massage (MOM) in nasopharyngeal carcinoma (NPC) patients receiving intensity-modulated radiotherapy.A total 158 NPC were randomly assigned 1:1 to routine care medication (the control group) or that with additional MOM treatment group). The primary endpoint was incidence severe radiotherapy-induced mucositis (SRTOM). In addition, time initiation duration RTOM SRTOM,...
Background. Immune checkpoint inhibitors (ICIs) have become a standard care in non-small-cell lung cancer (NSCLC). However, its application to epidermal growth factor receptor (EGFR)-mutant NSCLC patients is confronted with drug resistance. This study aimed clarify the potential role of Yes1-associated transcriptional regulator (YAP1) ICIs treatment for EGFR-mutant population. Methods. All clinical data were downloaded from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO)...
Currently, implantable fibrous medical devices still suffer from invisibility under current clinical imaging techniques. To address this problem, 2, 3, 5-triiodobenzoic acid (TIBA) was recruited as a contrast agent, and then set of iodinated poly(p-dioxanone) (PPDO) fibers fabricated via melt-spinning hybrid blends PPDO with TIBA (PPDO/TIBA). The impact content on the rheological behavior evaluated firstly. physical, chemical, thermal properties PPDO/TIBA were investigated accordingly by...
Soil drying cracking is the most common natural phenomenon affecting soil stability. Due to complexity of geometric shapes cracks during process, it has become a major problem in engineering science. The extremely irregular and complex crack networks formed civil materials can be quantitatively investigated using fractal theory. In this paper, dimension proposed characterize characteristics composite by adding recycled waste brick micro-powder. At same time, concept probability entropy...
Abstract Purpose: Coronavirus disease 2019 (COVID-19) has spread around the world. This retrospective study aims to analyze clinical features of COVID-19 patients with cancer and identify death outcome related risk factors. Methods: From February 10th April 15th, 2020, 103 were enrolled. Difference analyses performed between severe non-severe patients. A propensity score matching analysis, including 206 matched non-cancer performed. Next, we identified factors developed a nomogram for...
U-shaped ironless permanent magnet linear motors (IL-PMLMs) are widely implemented in precision manufacturing equipment with the advantages of small thrust and high positioning accuracy. However, structural parameter variations motor caused by assembly errors will increase ripple thus cause vibration reduce operating This paper uses Monte Carlo simulation to analyze tolerances motor's primary secondary parameters, including spacing position winding, height width magnets, thickness back iron....
Recent breakthrough therapies have improved survival rates in non-small cell lung cancer (NSCLC), but a paradigm for prospective confirmation is still lacking. Patientdatasets were mainly downloaded from TCGA, CPTAC and GEO. We conducted downstream analysis by collecting metagenes generated 42-gene subtype classifiers to elucidate biological pathways. Subsequently, scRNA, eRNA, methylation, mutation, copy number variation depicted phenotype perspective. Enhancing the clinical translatability...
The Machala Mine, which is located in the Eastern Tibetan Plateau, was one of highest coal mines world, with an elevation 5200 m. coals are rich a variety critical and harmful elements. However, occurrence enrichment mechanisms these elements not well understood, hinders assessment their environmental impacts recycling potential. Furthermore, mechanism identified expected to extend our understanding simultaneous multiple coal. A total 18 samples were collected from 14 (or carbonaceous...
<sec> <title>BACKGROUND</title> Non-small cell lung cancer (NSCLC) represents the foremost cause of cancer-related mortality, underscoring need for precise prognostic tools to enhance clinical decision-making. Existing models often fall short in providing reliable survival predictions. </sec> <title>OBJECTIVE</title> This study aims develop a robust machine learning ensemble model refine probability estimations NSCLC patients and support decisions. <title>METHODS</title> Following...
Small cell lung cancer (SCLC), which accounts for 15% of cancers, originated from the neuroendocrine (NE) lineage.1, 2 Relapse disease often occurs after traditional therapy, and chemo-immunotherapy is new first line treatment.2 Currently, there a lack robust indicators to predict immunotherapy SCLC.2 SCLC usually has higher tumour mutation burden (TMB) due smoking may benefit immunotherapy.1, As known all, high immunogenicity reflected in both microenvironments (TME) (e.g., TMB immunogenic...
Abstract In lung squamous cell carcinoma (LUSC), current mRNA vaccines show promising effect, despite lack of benefit for a large number patients. We categorized the ideal population and explored available targets. Leucine-rich repeat LGI family member 2 (LGI2), amine oxidase copper containing 1 (AOC1), periostin (POSTN), collagen type V alpha (COL5A2) were discovered using mutation, survival differential expression gene analyses. These four genes over-expressed, mutant, prognostic in...
Abstract Breakthrough therapies recently improve survival in lung adenocarcinoma (LUAD), yet we still lack a paradigm to support prospective confirmation. To classify three clusters including bronchioid, neuroendocrine, and squamoid, the non-negative matrix factorization (NMF) algorithm was first performed at The Cancer Genome Atlas (TCGA), Clinical Proteomic Tumor Analysis Consortium (CPTAC), Gene Expression Omnibus (GEO) preclinical models. In terms of prognostic value, squamoid cluster is...
Abstract Background Tumorigenic mechanisms and personalized therapeutic strategies for lung squamous cell carcinoma (LSCC) lack clarity. Practical LSCC animal models remain to be developed or improved. We aimed determine whether Yes-associated protein-1 (YAP1) promotes the stemness of airway epithelial basal cells tumor-initiating (TICs) spontaneous tumorigenesis in a self-developed YAP1 knock-in/Trp53 knockout mouse model. Methods Airway TICs were assessed by immunofluorescence (IF)...
Abstract Background The novel coronavirus disease 2019 (COVID-19) spreads rapidly among people and causes a global pandemic. It is of great clinical significance to identify COVID-19 patients with high risk death. Methods A total 2,169 adult were enrolled from Wuhan, China between February 10th April 15th, 2020. Difference analyses medical records performed severe non-severe groups as well survivors non-survivors. In addition, we developed decision tree classifier factors for death outcome....