A5101488390- Platelet Disorders and Treatments
- Autoimmune Bullous Skin Diseases
- Chronic Lymphocytic Leukemia Research
- Cerebrovascular and Carotid Artery Diseases
- Blood groups and transfusion
- Acute Ischemic Stroke Management
- Complement system in diseases
- Urticaria and Related Conditions
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- Sepsis Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Viral Infectious Diseases and Gene Expression in Insects
- Liver Disease Diagnosis and Treatment
- Insect Resistance and Genetics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Inflammatory Biomarkers in Disease Prognosis
- Neurological Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Hematological disorders and diagnostics
- Atrial Fibrillation Management and Outcomes
- Diabetes Treatment and Management
- Hepatocellular Carcinoma Treatment and Prognosis
Peking University People's Hospital
2020-2025
Peking University
2019-2025
National Clinical Research Center for Digestive Diseases
2020-2024
Fourth Affiliated Hospital of China Medical University
2019-2024
China Medical University
2020-2024
Beijing Shijitan Hospital
2022-2023
Capital Medical University
2020-2023
Xilinx (United States)
2021
National Natural Science Foundation of China
2021
Christie's
2021
Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to large sample size data, consistent definitions, large-scale multicenter findings, prediction models for ITP are unavailable. For first time, this study, we applied newly proposed criteria by International...
This study aims to analyze the imaging features of atherosclerotic plaques in middle cerebral artery (MCA) patients with recurrent ischemic stroke using vessel wall magnetic resonance (VWMRI) and investigate correlation between these recurrence stroke. Consecutive caused by stenosis MCA were collected. The divided into non-recurrent groups. We obtained VWMRI images 3.0T MRI black-blood sequences, differences characteristics clinical information two groups compared. A binary Logistic...
Corticosteroids (CSs) are the initial therapy for immune thrombocytopenia (ITP); however, their efficacy is not adequately predicted. As a novel biomarker, composition of gut microbiota non-invasively tested and altered in patients with ITP. This study aims to develop predictive model that leverages microbiome data predict CS response ITP within four weeks treatment. Metagenomic sequencing performed on fecal samples from 212 ITP, 152 whom underwent treatment follow-up. Predictive models...
Abstract Patients with steroid‐resistant or relapsed immune thrombocytopenia (ITP) suffer increased bleeding risk and impaired quality of life. Baricitinib, an oral Janus‐associated kinases (JAK) inhibitor, could alleviate both innate adaptive disorders without inducing in several autoimmune diseases. Accordingly, open‐label, single‐arm, phase 2 trial (NCT05446831) was initiated to explore the safety efficacy baricitinib ITP. Eligible patients were adults primary ITP who refractory...
In lieu of an adaptive immune system, apoptosis plays a central role in regulating cellular or environmental stimuli Lepidopteran insect cells during viral infection. Bombyx mori IBM1 gene, Drosophila Reaper orthologue, is localised mitochondria and can induce mitochondrial membrane potential loss. Further, expression up-regulated rapidly to protect from Ours the first evidence indicate that could interact with BmNPV IAP2 following B. nucleopolyhedrosisvirus (BmNPV) Our data function might...
Abstract Background Two species of wild silkworms, the Chinese oak silkworm ( Antheraea pernyi ) and castor Philosamia cynthia ricini , can acquire a serious disease caused by Nucleopolyhedrin Viruses (NPVs) (known as AnpeNPV PhcyNPV, respectively). The two viruses have similar polyhedral morphologies their viral fragments share high sequence similarity. However, physical maps genomes cross-infectivity are different. genome sequences isolates been published. Results We sequenced analyzed...
We aimed to investigate the frequency, risk factors, and outcome of active tuberculosis (TB) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). This retrospective, nested, case-control study reviewed data from 6236 patients who received allo-HSCT January 2008 December 2018 at a single center; thirty-three (0.5%) with TB 99 controls without were identified. performed propensity score matching by randomly selecting 3 for each identified patient according time follow-up...
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic transplantation (allo-HSCT) the only curable treatment. The outcomes after transplant are influenced by both disease characteristics patient comorbidities. To develop novel prognostic model to predict post-transplant survival of CMML patients, we identified risk factors applying univariable multivariable Cox proportional hazards regression derivation cohort. In analysis, advanced age (hazard...
Objective: To explore the correlation between portal vein pressure gradient (PPG) and hepatic (HVPG) in patients with hypertension (PHT). Methods: 752 cases (PHT) who underwent transjugular intrahepatic portosystemic shunt (TIPS) met enrollment criteria January 2016 to December 2019 were analyzed for vein, inferior vena cava pressure. Paired t-test was used analysis. Pearson test estimate coefficient of determination. P<0.05 considered statistically significant. Results: Wedged (WHVP),...
Nanoparticles of MnFe 2 O 4 have been synthesized under an induced magnetic field by a hydrothermal process. A strong correlation between the cation distribution and properties nanoparticles has identified. From results Mössbauer spectroscopy it found that zero fields 21% inversion occupancy in tetrahedral sites Fe 3+ cations, while this value decreases to 10% sample formed 0.25 T field. The explain well decrease saturation magnetization from 62.2 emu/g 52.8 for This provides understanding...
Intracranial hemorrhage (ICH) is a rare and life-threatening hemorrhagic event in patients with immune thrombocytopenia (ITP). However, its mortality related risk factors remain unclear. Herein, we conducted nationwide multicenter real-world study of ICH adult ITP patients. According to data from 27 centers China 2005 2020, the rate was 33.80% (48/142) adults. We identified by logistic univariate multivariate regression for 30-day training cohort 107 as follows: intraparenchymal (IPH),...
The present study aimed to investigate the relationship between an increase in pre- and post-operative neutrophil-lymphocyte ratio (NLR) superficial femoral artery in-stent restenosis (ISR) rate. We recruited 199 patients that underwent stenting for lower extremity arteriosclerosis obliterans at our hospital from March 2015 July 2018. Patients were divided into two groups according occurrence of ISR within 1 year (group 1, group 2, Non-ISR). after NLR (NLRafter) change (NLRratio) (P<0.001)...
Abstract Background Infections were the primary cause of death (34.3–55.5%) in patients with pemphigus. Skin was usually origin infections. The study aimed to explore features and associated factors bacterial skin infections (BSIs) inpatients Methods One hundred seventy-seven pemphigus hospitalizing from November 2014 April 2019 continuously recruited through Peking University First Hospital’s inpatient records records. Then, we retrieved clinical laboratory data characteristics BSIs....