A5040710006- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Blood groups and transfusion
- Biosensors and Analytical Detection
- Advanced Battery Materials and Technologies
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- RNA Interference and Gene Delivery
- Advancements in Battery Materials
- DNA and Nucleic Acid Chemistry
- Advanced Photocatalysis Techniques
- TiO2 Photocatalysis and Solar Cells
- Photodynamic Therapy Research Studies
- RNA modifications and cancer
- Advanced Battery Technologies Research
- Blood properties and coagulation
- Conducting polymers and applications
- Acute Lymphoblastic Leukemia research
- Electrochemical Analysis and Applications
- Advanced Nanomaterials in Catalysis
East China University of Science and Technology
2009-2025
Advanced Energy Materials (United States)
2025
Shanghai Jiao Tong University
2015-2024
Ruijin Hospital
2004-2024
Suzhou University of Science and Technology
2022-2024
Northwest University
2015-2021
Shenyang Pharmaceutical University
2012-2021
Zhongshan Hospital
1999-2021
Ministry of Education of the People's Republic of China
2018-2021
The First Affiliated Hospital, Sun Yat-sen University
2021
A unique biomimetic drug-delivery system composed of 4T1-breast-cancer-cell membranes and paclitaxel-loaded polymeric nanoparticles (PPNs) (cell-membrane-coated PPNs), demonstrates superior interactions to its source tumor cells elongated blood circulation, displays highly cell-specific targeting the homotypic primary metastases, with successful inhibition growth lung metastasis breast cancer cells.
The cell-specific targeting drug delivery and controlled release of at the cancer cells are still main challenges for anti-breast metastasis therapy. Herein, authors first report a biomimetic system composed doxorubicin (DOX)-loaded gold nanocages (AuNs) as inner cores 4T1 cell membranes (CMVs) outer shells (coated surface DOX-incorporated AuNs (CDAuNs)). CDAuNs, perfectly utilizing natural with homotypic hyperthermia-responsive ability to cap DAuNs photothermal property, can realize...
Limited blood circulation and poor tumor penetration are two main obstacles hampering the clinical translation of conventional nanosized drug delivery systems (NDDS). Here, red‐blood‐cell (RBC)‐mimetic nanoparticles (NPs) with long peptide‐enhanced for treating metastatic breast cancer reported. The RBC‐mimetic NPs composed a paclitaxel (PTX)‐loaded polymeric core hydrophilic RBC vesicle shell. display dramatically elongated an elimination half time 32.8 h, 5.8‐fold higher than that parental...
Mesoporous silica nanoparticles (MSNs), with their large surface area and tunable pore sizes, have been widely applied for anticancer therapeutic cargos delivery a high loading capacity. However, easy aggregation in saline buffers limited blood circulation lifetime hinder efficiency the efficacy. Here, new multifunctional MSNs-supported red-blood-cell (RBC)-mimetic theranostic long circulation, deep-red light-activated tumor imaging drug release were reported. High capacities achieved by...
The electrochemical properties of mixed‐phase composite electrolytes based on poly(ethylene oxide) (PEO), lithium salts , and ferroelectric materials have been studied. ion‐conduction lithium‐ion transference numbers the polymer were enhanced by addition these as a ceramic filler. conductivity behavior electrolyte depended combination salt materials. enhancement in PEO‐LiX with was rationalized correlating association tendency anions cations spontaneous polarization ceramics due to their...
The ion‐conduction properties of a polyethylene oxide (PEO)‐based composite polymer electrolyte comprised PEO, , and the ferroelectric material were studied. addition resulted in an increase conductivity over temperature range 25–115°C. optimum amount (purity 99.9%,particle size 0.6–1.2 μm was 1.4 wt %, which is very low comparison with previosly reported electrolytes. ionic containing % at 25°C, least one order magnitude higher than that pristine . transport number lithium ion this...
Optimal nanosized drug delivery systems (NDDS) require long blood circulation and controlled release at target lesions for efficient anticancer therapy. Red cell (RBC) membrane‐camouflaged nanoparticles (NPs) can integrate flexibility of synergetic materials highly functionality RBC membrane, endowed with many unique advantages delivery. Here, new near‐infrared (NIR)‐responsive membrane‐mimetic NPs NIR‐activated cellular uptake treating metastatic breast cancer are reported. An NIR dye is...
Prolonged circulation, specific and effective uptake by tumor cells, rapid intracellular drug release are three main factors for the delivery systems to win battle against metastatic breast cancer. In this work, a microenvironment‐adaptive nanoparticle co‐loading paclitaxel (PTX) anti‐metastasis siRNA targeting Twist is prepared. The consists of pH‐sensitive core, cationic shell, matrix metalloproteinase (MMP)‐cleavable polyethylene glycol (PEG) corona conjugated via peptide linker. PEG will...
The underlying molecular pathogenic mechanisms remain unknown in the majority of human pituitary tumors. GADD45γ is a member growth arrest and DNA damage-inducible gene family that functions negative regulation cell growth. We have found mRNA expression significantly different between normal tissue clinically nonfunctioning adenomas using cDNA-representational difference analysis. Although was tissue, it detectable only 1 18 tumors by RT-PCR. Furthermore, this not expressed GH- or...
CITED1, a CBP/p300-binding nuclear protein that does not bind directly to DNA, is transcriptional coregulator. Here, we show evidence CITED1 functions as selective coactivator for estrogen-dependent transcription. When transfected, enhanced activation by the ligand-binding/AF2 domain of both estrogen receptor-α (ERα) and ERβ in an manner, but it affected activities other receptors only marginally. bound ERα manner through its transactivating domain, this binding activity was separable from...
DNA methylation is used to dynamically reprogram cells in the course of early embryonic development mammals. 5-Hydroxymethylcytosine (5-hmC-DNA) plays essential roles demethylation processes. 5-Methylcytosine (5-mC-DNA) oxidized 5-hmC-DNA by 10-11 translocation proteins, which are relatively high abundance stem and neurons. A new method was developed herein quantify based on selective electrogenerated chemiluminescence (ECL) labeling with specific oxidation 5-hmC 5-fC KRuO4. thiolated...
The development of multidrug resistance (MDR) in human hepatocellular carcinoma (HCC) is one the major obstacles for successful chemotherapy HCC. Co-delivery sorafenib (SF) and survivin shRNA (shSur) was postulated to achieve synergistic effects reversing MDR, suppressing tumor growth angiogenesis. For this purpose, work, SF shSur co-loaded pluronic P85-polyethyleneimine/d-α-tocopheryl polyethylene glycol 1000 succinate nanocomplexes (SSNs) were first designed developed treatment drug...