A5081348557- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chronic Lymphocytic Leukemia Research
- Elbow and Forearm Trauma Treatment
- Multiple Myeloma Research and Treatments
- Blood properties and coagulation
- Orthopedic Surgery and Rehabilitation
- Immune Cell Function and Interaction
- Ferroptosis and cancer prognosis
- Shoulder Injury and Treatment
- Bone fractures and treatments
- Autoimmune Bullous Skin Diseases
- Lipid metabolism and disorders
- Immune cells in cancer
- Renal Transplantation Outcomes and Treatments
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- RNA modifications and cancer
- Bacterial Infections and Vaccines
- HIV Research and Treatment
- Hip and Femur Fractures
- Circular RNAs in diseases
- MicroRNA in disease regulation
Qilu Hospital of Shandong University
2016-2025
Children's Hospital of Chongqing Medical University
2017-2024
Chongqing Medical University
2017-2024
Second Affiliated Hospital of Nanjing Medical University
2022-2024
Hangzhou Normal University
2024
National Clinical Research
2024
Chongqing Maternal and Child Health Hospital
2024
Dalian Medical University
2024
Second Affiliated Hospital of Chongqing Medical University
2024
Nanjing Second Hospital
2023
In addition to antiplatelet autoantibodies, CD8(+) cytotoxic T lymphocytes (CTLs) play an important role in the increased platelet destruction immune thrombocytopenia (ITP). Recent studies have highlighted that desialylation leads clearance via hepatocyte asialoglycoprotein receptors (ASGPRs). Whether cells induce ITP remains unclear. Here, we investigated cytotoxicity of towards platelets and ITP. We found fresh was significantly higher patients with positive than those without controls....
The management of chronic immune thrombocytopenia (ITP) remains to be a challenge. Oseltamivir phosphate is sialidase inhibitor agent used treat influenza in the conventional sense. At present, we demonstrate for first time that an adult ITP patient with anti-GP Ib/IX autoantibody, who was resistant corticosteroids, IVIG, recombinant human thrombopoietin, rituximab, danazol and vindesine, but successfully treated oseltamivir phosphate. Through flow cytometric analysis β-galactose β-GlcNAc...
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) megakaryocytes contributed impaired ITP. Decitabine (DAC), a demethylating agent, is known promote cell differentiation at doses. However, whether decitabine potential promoting release ITP unclear. In this study, we...
We conducted a prospective, multicenter study to evaluate the efficacy and safety of low-dose decitabine in adult patients with refractory immune thrombocytopenia. Adult who did not respond to, tolerate, or were unwilling undergo splenectomy, either baseline platelet count less than 30 × 109 /L presence bleeding symptoms further need ITP-specific treatments, enrolled. Patients received at 3.5 mg/m2 intravenously for three consecutive days per cycle, cycles four-week interval between cycles....
Long non-coding RNAs (lncRNAs) exert critical effects in the process of malignant cancers and lncRNA LOXL1 Antisense RNA 1 (LOXL1-AS1) has been demonstrated to be a pro-oncogene multiple tumor types. In current study, we illuminated precise roles LOXL1-AS1 development ovarian cancer. is significantly overexpressed carcinoma tissue compared with adjacent non‐cancerous sample. The luciferase reporter gene assay reveals relationship between miR‐18b‐5p, miR‐18b‐5p its target gene, Vacuolar...
Cytotoxic T lymphocytes (CTLs)-mediated platelet destruction plays an important role in the pathogenesis of primary immune thrombocytopenia (ITP). The programmed cell death protein 1 (PD-1) signaling can turn off autoreactive cells and induce peripheral tolerance. Herein, we found that expression PD-1 its ligand PD-L1 on CD8 + from ITP patients was decreased. Activating pathway by PD-L1-Fc fusion inhibited CTLs-mediated vitro . promoter hypermethylation patients, resulting decreased...
Background: The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development multiple tumor types, but its function ovarian cancer remains not well investigated. In this study, we mainly investigated miR-139-3p progression cancer. Methods: levels cells and tissues were detected using quantitative real-time-PCR (qRT-PCR) assay. proliferation, colony formation, migration invasion cell determined, respectively. A luciferase reporter assay was used to confirm...
To investigate the role of Interleukin-34 (IL-34) in acute T cell-mediated rejection (TCMR) following renal transplantation.
Abstract Immune thrombocytopenia (ITP) is an acquired autoimmune disease characterized by immune mediated decrease in platelet number. Disturbance of CD4 + T‐cell homeostasis with simultaneous CD25 Foxp3 regulatory T cells (Tregs) as well unrestricted proliferation and activation peripheral effector underpin the pathophysiology ITP. Indirubin active ingredient a traditional Chinese herb called Indigofera tinctoria L. which clinically used for treatment ITP patients. Whether indirubin targets...
Rare but critical bleeding events in primary immune thrombocytopenia (ITP) present life-threatening complications patients with ITP, which severely affect their prognosis, quality of life, and treatment decisions. Although several studies have investigated the risk factors related to large sample size data, consistent definitions, large-scale multicenter findings, prediction models for ITP are unavailable. For first time, this study, we applied newly proposed criteria by International...
<title>Abstract</title> Background Thrombocytopenia is less common but shows high risk of early mortality in newly diagnosed multiple myeloma (NDMM) patients. In the era novel agents-based induction therapy (NAIT), it unclear whether NAIT can overcome poor prognosis associated with thrombocytopenia. Objectives To evaluate prognostic implications thrombocytopenia NDMM Methods We retrospectively analyzed 1363 patients baseline characteristics, treatment response and survival, further performed...
The best approach between closed reduction and open in the treatment of total displaced rotated LCFs is still being debated. This study aimed to comparatively evaluate clinical outcomes complications vs. lateral condyle fractures children.We retrospectively evaluated 46 children who underwent surgical for totally fractures. Thirty-one percutaneous pinning (ORPP). Ten (CRPP). Five were changed ORPP procedures because failure attempts. Clinical groups compared.Among three groups, no...