A5101493588- Renal Transplantation Outcomes and Treatments
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Organ Transplantation Techniques and Outcomes
- MicroRNA in disease regulation
- Parathyroid Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Medical Imaging and Pathology Studies
- Bone health and treatments
- TGF-β signaling in diseases
- Ferroptosis and cancer prognosis
- RNA and protein synthesis mechanisms
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Reproductive System and Pregnancy
- Estrogen and related hormone effects
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Trace Elements in Health
- Peptidase Inhibition and Analysis
- Bone and Joint Diseases
- Epigenetics and DNA Methylation
Nanjing Medical University
2015-2025
Jiangsu Province Hospital
2015-2025
Chinese University of Hong Kong
2024
University of Hong Kong
2024
Zhejiang Chinese Medical University
2023
657 Oslo
2013
University of Pittsburgh
2006-2010
Second Affiliated Hospital of Nanjing Medical University
2008
University of California, San Francisco
1995
Arginine-rich domains are used by a variety of RNA-binding proteins to recognize specific RNA hairpins. It has been shown previously that 17-aa arginine-rich peptide from the human immunodeficiency virus Rev protein binds specifically its site when is in an alpha-helical conformation. Here we show related peptides splicing factors, viral coat proteins, and bacteriophage antiterminators (the N proteins) also have propensities form alpha-helices require helical conformations bind their cognate...
Plasminogen activator inhibitor-1 (PAI-1) is a multifunctional glycoprotein that plays critical role in the pathogenesis of chronic kidney and cardiovascular diseases. Although transforming growth factor (TGF)-β1 known inducer PAI-1, how it controls PAI-1 expression remains enigmatic. Here we investigated mechanism underlying TGF-β1 regulation tubular epithelial cells (HKC-8). Surprisingly, overexpression Smad2 or Smad3 HKC-8 blocked induction by TGF-β1, whereas knockdown them sensitized to...
Background Chronic kidney disease (CKD) is often accompanied by alterations in the metabolic profile of body, yet causative role these changes onset CKD remains a subject ongoing debate. This study investigates links between metabolites and leveraging results genomewide association (GWAS) from 486 blood metabolites, employing bulk two-sample Mendelian randomization (MR) analyses. Building on that exhibit causal relationship with CKD, we delve deeper using enrichment analysis to identify...
Smad ubiquitination regulatory factor-2 (Smurf2) is an E3 ubiqutin ligase that plays a pivotal role in regulating TGF-beta signaling via selectively targeting key components of the pathway for degradation. In this study, we have investigated regulation Smurf2 expression, its target specificity, and functional implication induction fibrotic kidney. Immunohistochemical staining revealed was upregulated specifically renal tubules kidney biopsies from patients with various nephropathies. vitro,...
Smad transcriptional co-repressor SnoN acts as an antagonist that tightly controls the trans-activation of TGF-beta/Smad target genes. protein is reduced progressively in fibrotic kidney after obstructive injury, suggesting loss a critical event leads to uncontrolled fibrogenic signaling. However, mechanism underlying downregulation remains unknown. This study investigated regulation and renal expression vivo. Whereas was markedly diminished, its mRNA levels remained relatively constant...
To investigate the role of Interleukin-34 (IL-34) in acute T cell-mediated rejection (TCMR) following renal transplantation.
Signaling by transforming growth factor-beta (TGF-beta), a regulator of several biological processes, including renal fibrosis, is mediated, in part, the Smad proteins. Tight control level and activity critical for proper TGF-beta functions. Here, we have investigated mechanisms involved regulating Smad3 expression. In human glomerular mesangial cells, protein levels were specifically reduced 24 h TGF-beta1 treatment, whereas Smad2 Smad4 not. increased endogenous ubiquitination, proteasome...
Introduction: To investigate the long-term effects of novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection and disease (COVID-19) on prognosis kidney transplant recipients. Methods: A 1-year retrospective study was carried out among 362 domestic recipients who were divided into observational control groups. Stratification analysis then to whether repeated infections severity could influence graft prognosis. Kaplan-Meier curves assessed survival, while one-way variance...
The assessment and prevention of mineral bone disorder (MBD) in kidney transplant recipients (KTRs) have not been standardized. This study aimed to evaluate MBD one year after transplantation (KT) identify the influencing factors MBD.A total 95 KTRs our center were enrolled. changes density (BMD) metabolism biochemical markers, including serum calcium (Ca), phosphorus(P), 25-hydroxyvitamin D(25(OH)vitD), intact parathyroid hormone (iPTH), alkaline phosphatase, osteocalcin (OC), type I...
MicroRNAs are short non-coding RNAs, which have been implicated in several biological processes. Aberrant expression of the microRNA miR-122 has frequently reported malignant cancers. However, mechanism underlying effects renal cell carcinoma remains unknown. The aim this study was to determine function and identify a novel molecular target regulated by miR-122. We measured levels Sprouty2 six tissue samples adjacent non-tumor tissues western blot analysis. then used reverse transcription...
BACKGROUND:The related mechanisms involved in allograft interstitial fibrosis and chronic dysfunction (CAD), following renal transplant, remain largely unknown. Here, we explored the role of hepatocyte growth factor (HGF) treatment on endothelial-to-mesenchymal transition (EndMT) as a new way to target prevent kidney improve outcomes for transplant recipients. MATERIAL AND METHODS:We extracted proteins mRNAs from human umbilical vein endothelial cells (HUVECs) glomerular (HRGECs) treated...
To evaluate long-term renal graft prognosis and the role of rapamycin from a single-center in China over 30-year follow-up.
Objective: T cell-mediated injury plays an important role in the pathogenesis of autoimmune premature ovarian insufficiency (POI). The purpose this study was to assess percentage CD4+CD25+FOXP3+ regulatory (Treg) cells and level forkhead box protein 3 (FOXP3) mRNA expression POI patients.Methods: case–control compared 30 patients with healthy subjects. Peripheral blood mononuclear were collected. Treg measured by flow cytometry using specific monoclonal antibodies recognizing CD4+, CD25+,...
Acute rejection (AR) is a common complication of kidney transplantation. Nuclear factors activated T cells (NFATs) are transcription involved in the activation lymphocytes, but their association with AR unclear. This retrospective, case–control study included 200 renal transplant recipients who were divided into group (n = 69) and stable 131). Their blood samples collected, DNA was extracted from whole blood. High-throughput next-generation sequencing used to identify single nucleotide...
Chronic allograft dysfunction (CAD) is a major factor that hinders kidney transplant survival in the long run. Epithelial-mesenchymal transition (EMT) has been confirmed to significantly contribute interstitial fibrosis/tubular atrophy (IF/TA), which main histopathological feature of CAD. Aberrant expression regulator calcineurin 1 (RCAN1), recognized as an endogenous inhibitor phosphatase, shown be extensively involved various diseases. However, it remains unclear how RCAN1.4 regulates...