A5101940472- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Protease and Inhibitor Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Muscle activation and electromyography studies
- Gout, Hyperuricemia, Uric Acid
- Folate and B Vitamins Research
- Infectious Diseases and Tuberculosis
- Neurological Disorders and Treatments
- Potassium and Related Disorders
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Esophageal and GI Pathology
- Bone health and treatments
- Acute Kidney Injury Research
- Botulinum Toxin and Related Neurological Disorders
- Peptidase Inhibition and Analysis
- Mycobacterium research and diagnosis
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
- Neurological Disease Mechanisms and Treatments
- Abdominal vascular conditions and treatments
- Ginkgo biloba and Cashew Applications
- Acute Ischemic Stroke Management
Zhujiang Hospital
2022-2025
Zhejiang University
2025
Southern Medical University
2022-2025
Beijing Friendship Hospital
2024
Capital Medical University
2024
Xuzhou Medical College
2023
Lianyungang Oriental Hospital
2023
Second Affiliated Hospital of Nanjing Medical University
2023
Renji Hospital
2021
Shanghai Jiao Tong University
2021
Background Inflammation plays a pivotal role in the pathogenesis of Parkinson’s disease (PD). However, correlation between peripheral inflammatory markers and severity PD remains unclear. Methods The following items plasma were collected for assessment among patients with ( n = 303) healthy controls (HCs; assessed neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR) neutrophil-to-high-density-lipoprotein (NHR) plasma, neuropsychological assessments performed all PD. Spearman...
In a prospective longitudinal study with 218 Parkinson's disease (PD) patients in the discovery cohort and 84 validation cohort, we aimed to identify novel blood biomarkers predicting disability milestones PD. Through Least Absolute Shrinkage Selection Operator-Cox (Lasso-Cox) regression, developed nomogram predictive model Linear mixed-effects models, identified low level of plasma fibronectin (pFN) as one best-performing risk markers milestones. A pFN was associated short milestone-free...
This study seeks to determine the association between serum uric acid (SUA) and accelerated aging among middle-aged older adults in China, as well assess relationship SUA trajectories risk of aging. We utilized data from China Health Retirement Longitudinal Study (CHARLS), selecting participants who completed follow-ups 2011 2015. Biological age was estimated using Klemera-Doubal method, determined by calculating difference an individual's biological their chronological age. Logistic...
Quantitative electroencephalography (QEEG) is a reliable and non-invasive diagnostic tool to quantify cortical synaptic injury or loss in the clinical assessment of neurodegenerative diseases, may be able differentiate various types dementia. We investigated if QEEG indices can Parkinson's Disease (PD) with nondementia (PD-ND) from PD dementia (PDD), determine correlate inflammation lipid metabolism markers PD.This study collected data between July 1, 2018 2021 Zhujiang Hospital Southern...
It has been suggested that trimethylamine N-oxide (TMAO) is related to Parkinson's disease (PD) in observational studies. However, the direction of this association inconsistent. An exploratory Mendelian randomization study was conducted investigate whether TMAO and its precursors have a causal relationship with PD.Summary statistics were obtained for single nucleotide polymorphisms circulating levels TMAO, betaine, carnitine choline, corresponding data risk, age at onset progression PD from...
Abstract Retinal thickness is related to Parkinson’s disease (PD), but its association with the severity of PD still unclear. We conducted a Mendelian randomized (MR) study explore between retinal and PD. For two-sample MR analysis, summary statistics obtained from genome-wide studies on nerve fiber layer (RNFL) ganglion cell inner plexiform (GCIPL) were employed as exposure, while associated used outcome. The primary approach utilized was inverse variance weighted. To correct for multiple...
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) has been used to treat various neurological disorders. However, the molecular mechanism underlying therapeutic effect of rTMS on Parkinson’s disease (PD) not fully elucidated. Neuroinflammation like regulatory T-cells (Tregs) appears be a key modulator progression in PD. If affects peripheral Tregs PD remains unknown. Methods Here, we conducted prospective clinical study (Chinese ClinicalTrials. gov: ChiCTR 2100051140)...
The assessment and prevention of mineral bone disorder (MBD) in kidney transplant recipients (KTRs) have not been standardized. This study aimed to evaluate MBD one year after transplantation (KT) identify the influencing factors MBD.A total 95 KTRs our center were enrolled. changes density (BMD) metabolism biochemical markers, including serum calcium (Ca), phosphorus(P), 25-hydroxyvitamin D(25(OH)vitD), intact parathyroid hormone (iPTH), alkaline phosphatase, osteocalcin (OC), type I...
Monitoring allograft function during the early stages is crucial, and therefore requires biomarkers more sensitive than serum creatinine (Scr). Kidney injury molecular-1 (KIM-1) a potent biomarker; however, disparities exist in literature concerning its predictive value function. Therefore, this study aimed to evaluate for long-term prognosis of kidney transplantation patients.A prospective with cohort comprising 160 patients scheduled was conducted power urinary KIM-1 (uKIM-1) other renal...
Background and Purpose: Hemoglobin is one of the main proteins in erythrocytes. There are significant correlations between low hemoglobin white matter hyperintensities (WMH) cognitive impairment. This study explored whether erythrocytopenia has predictive value for vascular impairment (VCI) patients with WMH. Method: We conducted a cross-sectional 302 patients, including 62 cerebral small vessel disease 240 stroke. Basic demographic data fasting blood were collected. First, all divided into...
Mycobacterium iranicum is characterized by rapid growth and orange-pigmented scotochromogenic colonies. However, it uncommon for M. to invade the central nervous system. A man nearly 60 years old was referred our hospital because of a seizure unconsciousness. After admission, patient had fever dizziness without obvious abnormalities in cerebrospinal fluid, except an increase neutrophils. Metagenomic next-generation sequencing DNA testing were positive iranicum. The treated with imipenem,...
Background and Objectives: In a prospective longitudinal cohort study, we aimed to identify novel blood biomarkers that can predict the risk of onset disability milestones in Parkinson's disease (PD). Methods: total number 302 PD patients comprising 218 discovery 84 validation cohort, measured levels 19 peripheral inflammatory markers. Using Lasso-Cox regression, developed nomogram predictive model identified best performing marker predicting milestones. We then investigated correlation...
<title>Abstract</title> <bold>Background</bold> Repetitive transcranial magnetic stimulation (rTMS) has been used to treat various neurological disorders. However, the molecular mechanism underlying therapeutic effect of rTMS on Parkinson’s disease (PD) not fully elucidated. Neuroinflammation like regulatory T-cells (Tregs) appears be a key modulator progression in PD. If affects peripheral Tregs PD remains unknown. <bold>Methods</bold> Here, we conducted prospective clinical study (Chinese...
Background: Evidence suggests that peripheral metabolic inflammatory derangements are associated with the progression of Parkinson’s Disease(PD) and can promote destruction blood brain barrier(BBB); however, no mediators in dynamically monitoring disease have been identified. We aimed to screen validate potential marker(s) predicting poor prognosis PD.Methods: In this two-stage multicenter prospective study, markers including plasma fibronectin(pFN) phosphorylated α-synuclein from recruited...
Background: Quantitative electroencephalography (QEEG) is a reliable and noninvasive diagnostic tool to quantify cortical synaptic injury or loss in the clinical assessment on neurodegenerative diseases, plays critical roles distinguishing various dementia. We here aimed find prominent QEEG indices differentiation of Parkinson’s Disease (PD) with nondementia (PD-ND) PD dementia (PDD). Besides, correlations neuro-inflammation lipid metabolism markers are identified.Methods: Thirty-one PDD, 47...