A5060212801- Oral Health Pathology and Treatment
- Head and Neck Cancer Studies
- Oral microbiology and periodontitis research
- Oral and Maxillofacial Pathology
- Macrophage Migration Inhibitory Factor
- Molecular Biology Techniques and Applications
- Platelet Disorders and Treatments
- Mycobacterium research and diagnosis
- Glioma Diagnosis and Treatment
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Neurofibromatosis and Schwannoma Cases
- Advanced Radiotherapy Techniques
- BRCA gene mutations in cancer
- RNA modifications and cancer
- Vasculitis and related conditions
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Immune cells in cancer
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Soft tissue tumor case studies
- Cancer, Lipids, and Metabolism
Hubei University of Medicine
2025
Yale University
2006-2024
Xiangya Hospital Central South University
2022-2023
Central South University
2022-2023
Hospital for Sick Children
2022-2023
Hunan Cancer Hospital
2022-2023
SickKids Foundation
2022-2023
Nanjing University of Chinese Medicine
2023
Center for Discovery
2023
Hackensack Meridian Health
2023
Purpose: ras oncogenic activation has long been demonstrated in thyroid carcinomas of follicular cell derivation, but no consistent relationship shown between mutations and clinicopathologic features. Materials Methods: We analyzed H-, K-, N-ras by polymerase chain reaction–single-strand conformational polymorphism followed DNA sequencing 125 carcinoma specimens from 107 patients, to include tumors covering the entire spectrum tumor differentiation. Results: Mutations were identified four...
Regulatory T (T reg ) cells and cancer-associated fibroblasts (CAFs) jointly promote tumor immune tolerance tumorigenesis. The molecular apparatus that drives cell CAF coordination in the microenvironment (TME) remains elusive. Interleukin 33 (IL-33) has been shown to enhance fibrosis IL1RL1 + accumulation during tumorigenesis tissue repair. We demonstrated signaling greatly dampened antitumor activity of both IL-33 PD-1 blockade. Whole single-cell RNA sequencing (scRNA-seq) analysis...
The role of the cytokine, macrophage migration inhibitory factor (MIF), and its receptor, CD74, was assessed in autoimmune hepatitis (AIH) primary biliary cirrhosis (PBC). Two MIF promoter polymorphisms, a functional -794 CATT5-8 microsatellite repeat (rs5844572) -173 G/C single-nucleotide polymorphism (rs755622), were analyzed DNA samples from over 500 patients with AIH, PBC, controls. We found higher frequency proinflammatory high-expression CATT7 allele compared to whereas lower both AIH...
Background The authors measured epigenetic age acceleration (EAA) during and after cancer treatment its association with inflammation fatigue, which is a debilitating symptom in patients cancer. Methods Patients who had head neck without distant metastases were assessed before, immediately after, at 6 months 12 postradiotherapy. Blood DNA methylation was using proprietary bead chip (the Illumina MethylationEPIC BeadChip). EAA calculated the Levine clock (DNAmPhenoAge), adjusted for...
Abstract Objective To investigate the potential association between functional polymorphisms in gene for innate mediator, macrophage migration inhibitory factor (MIF), and clinical expression of systemic sclerosis (SSc). Methods Genomic DNA samples data were collected from Scleroderma Family Registry Repository at University Texas Health Science Center Houston. A total 740 subjects studied; 203 them had diffuse cutaneous SSc (dcSSc), 283 limited (lcSSc), remaining 254 healthy served as...
To test the effects of a novel tylophorine analog, DCB 3503, on prevention and treatment collagen-induced arthritis (CIA) to elucidate its underlying mechanisms.DBA/1J mice were immunized with type II collagen, in some cases, lipopolysaccharide (LPS) was used boost development arthritis. 3503 injected intraperitoneally before or after onset CIA. Mice monitored assess clinical severity disease, pathologic changes joints examined histologically. Levels tumor necrosis factor alpha (TNFalpha)...
Genetic predisposition to coronavirus disease 2019 (COVID-19) may contribute its morbidity and mortality. Because cytokines play an important role in multiple phases of infection, we examined whether commonly occurring, functional polymorphisms macrophage migration inhibitory factor (MIF) are associated with COVID-19 infection or severity.To determine associations common MIF symptomatic severity.This retrospective case-control study utilized 1171 patients from three tertiary medical centers...
Ovarian cancer (OC) is one of the commonest and deadliest diseases that threaten health women worldwide. It essential to find out its pathogenic mechanisms therapeutic targets for OC patients. Although NUF2 (Ndc80 kinetochore complex component) has been suggested play an important role in development many cancers, but little known about function roles proteins regulate OC. This study aimed investigate effect on tumorigenicity activities interact with NUF2.Oncomine database...
The drug combination of biapenem (BIPM) and xuebijing injection (XBJ) is commonly applied for the treatment sepsis in China. However, potential synergistic mechanism still enigmatic. There have been no studies focused on plasma metabolome alterations after intervention this combination. In work, an untargeted metabolomics approach was performed by liquid chromatography-mass spectrometry coupled with multivariate statistical analysis to provide new insights into effect BIPM XBJ. We...
The use of antisense oligonucleotides represents a novel, genetically based therapy. biostability and pharmacokinetics 33-mer self-stabilized oligodeoxynucleotide with significant anti-HIV activity was determined in rats after intravenous administration [35S]oligodeoxynucleotide. Plasma disappearance the labeled could be described by two-compartment model, half-lives 0.54 41.44 h. plasma remained mainly intact. Urinary excretion represented major elimination pathway, approximately 27%...
Backgrounds: To identify diagnostic biomarkers for differentiating oral squamous cell carcinoma (OSCC) from erosive lichen planus (OELP) and investigate potential associated with malignant transformation. Methods: In this study, 72 patients OSCC, 75 OELP subjects were recruited. Their plasma samples analyzed by ultra-high-performance liquid chromatography quadrupole-Orbitrap high-resolution accurate mass spectrometry, (UHPLC/Q-Orbitrap HRMS). Principal component analysis, orthogonal partial...
Oral leukoplakia (OLK) is the most common precancerous lesion in oral cavity. This study aimed to explore key biomarkers for monitoring OLK early diagnosis of squamous cell carcinoma (OSCC) and screen small-molecule drugs prevention OSCC.The Gene Expression Omnibus (GEO) database was explored extract two microarray datasets, namely, GSE85195 GSE25099. The data normal group, OSCC group were analyzed by weighted gene coexpression network analysis (WGCNA) identify significant module...
Mannosidase Alpha Class 2B Member 1 (MAN2B1) gene encodes lysosomal alpha-d-mannosidase involved in the ordered degradation of N-linked glycoproteins. Alteration MAN2B1 has been proved to be accountable for several diseases. However, relationship between and glioma malignancy remains unclear. In this study, RNA-seq data from The Cancer Genome Atlas Chinese Glioma datasets were analyzed explore correlation clinicopathological features, prognosis, somatic mutations gliomas. We found that was...
Oral Lichen Planus (OLP) is one of the most common oral mucosal diseases. However, current diagnostic method for OLP has limitations, and sometimes it easy to be misdiagnosed. Salivary metabolomics may provide new ideas diagnosis OLP.To identify biomarkers early detection OLP.A non-targeted metabolomic analysis was established based on UHPLC-Q-Orbitrap HRMS (Ultra-performance liquid chromatography-quadrupole/orbitrap high resolution mass spectrometry) analyze differential metabolites in...
Background: Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disorder and precancerous oral lesion with high incidence. The current diagnostic method of OLP very limited metabolomics may provide new approach for quantitative evaluation. Methods: Ultra-Performance Liquid Chromatography-Quadrupole/Orbitrap High Resolution Mass Spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to analyze the change metabolites in serum patients OLP. A total 115 124 healthy controls were...
Functional screening for compounds represents a major hurdle in the development of rational therapeutics B-acute lymphoblastic leukemia (B-ALL). In addition, using cell lines as valid models evaluating responses to novel drug therapies raises serious concerns, are prone genotypic/phenotypic drift and loss heterogeneity vitro. Here, we reported that OP9 cells, not OP9-derived adipocytes (OP9TA), support growth primary B-ALL cells To identify factors from performed RNA-Seq analyze gene...
To explore metabolic biomarkers related to erosive and reticulated oral lichen planus (OLP) by non-targeted metabolomics methods correlate metabolites with gene expression, investigate the pathological network pathways of OLP from perspective metabolism.A total 153 individuals were enrolled in this study, including 50 patients (EOLP), 51 (ROLP), 52 healthy controls (HC). The ultra-high-performance liquid chromatography quadrupole-Orbitrap high-resolution accurate mass spectrometry...