A5100385297- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Glaucoma and retinal disorders
- Urinary Bladder and Prostate Research
- Assisted Reproductive Technology and Twin Pregnancy
- Connexins and lens biology
- HIV, Drug Use, Sexual Risk
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Ovarian function and disorders
- Systemic Lupus Erythematosus Research
- Reproductive Biology and Fertility
- HIV/AIDS Research and Interventions
- Heart Rate Variability and Autonomic Control
- Cerebral Venous Sinus Thrombosis
- Glycogen Storage Diseases and Myoclonus
- Digestive system and related health
- Vitamin C and Antioxidants Research
- Nanoparticles: synthesis and applications
- Retinoids in leukemia and cellular processes
- Light effects on plants
- Heme Oxygenase-1 and Carbon Monoxide
- Climate Change and Health Impacts
- Inflammasome and immune disorders
- PI3K/AKT/mTOR signaling in cancer
Tianjin Medical University General Hospital
2025
China Rehabilitation Research Center
2025
Capital Medical University
2025
Shandong Center for Disease Control and Prevention
2023-2024
Nanjing Medical University
2024
Shandong Provincial Hospital
2022-2024
Shandong University
2018-2024
Northwest Women's and Children's Hospital
2022-2024
Nankai University
2023-2024
Education Department of Heilongjiang Province
2022
Ménière's disease, a multifactorial disorder of the inner ear, is characterized by severe vertigo episodes and hearing loss. Although role immune responses in disease has been proposed, precise mechanisms remain undefined. Here, we show that downregulation serum/glucocorticoid-inducible kinase 1 associated with activation NLRP3 inflammasome vestibular-resident macrophage-like cells from patients. Serum/glucocorticoid-inducible depletion markedly enhances IL-1β production which leads to...
The stria vascularis (SV) generates the endocochlear potential (EP) in inner ear and is necessary for proper hair cell (HC) mechanotransduction hearing. Cell junctions are indispensable establishment of compositionally distinct fluid compartments ear. Ototoxic drug cisplatin can damage SV cause sensorineural hearing loss; however, underlying mechanisms behind such injury unclear. In this study, after intraperitoneal injection (3 mg/kg/day 7 days) mice, we determined auditory function by EP...
Abstract Meniere’s disease (MD) is a disorder of the inner ear characterized by episodes spontaneous vertigo, fluctuating hearing loss, and tinnitus. Recent studies have demonstrated that IgE may play role in pathogenesis MD. Patients with MD (n = 103), acoustic neuroma 5), healthy subjects 72) were recruited into study. Serum from participants was analyzed for type 2–related cytokines. CD23 expression levels vestibular end organs patients, C57BL/6 mice, or mouse HEI-OC1 cells analyzed....
Abstract STUDY QUESTION Does an increased dosing of FSH improve the live birth rate as compared to standard in expected poor responders who undergo IVF? SUMMARY ANSWER In this trial, women with response allocated did not have a statistically significant increase cumulative births dose. WHAT IS KNOWN ALREADY Poor ovarian reserve leads worse IVF outcomes owing low number and quality oocytes. Clinicians often individualize dose using tests, including antral follicle count (AFC), basal plasma or...
Abstract Ménière’s disease (MD) is a complex inner ear disorder characterized by range of symptoms, with its pathogenesis linked to immune-related mechanisms. Our previous research demonstrated that IL-1β maturation and release can trigger cell pyroptosis, exacerbating the severity endolymphatic hydrops in mouse model; however, specific mechanism through which influences MD symptoms remains unclear. This study conducted on patients examined changes protein signatures vestibular end organs...
Abstract Objective The endocannabinoid system (ECS) regulates bone turn-over and remodeling. Chronic intermittent hypoxia (CIH) occurring during obstructive sleep apnea (OSA) may lead to disorders of the ECS metabolism abnormalities. This study aimed investigate whether or not cannabinoid receptor 1 (CB1R) antagonist rimonabant (Ri) alleviates abnormalities destruction induced by chronic (CIH). Methods Healthy male Sprague Dawley (SD) rats (n=48) were randomly divided into 6 groups 8 rats: 2...
Baichanting (BCT),a traditional Chinese medicine prescription, is a combination of Acanthopanax senticosus, Paeonia lactiflora, and Uncaria three herbs, which has the effect benefiting kidney calming liver. The study was aimed at investigating protective BCT against Parkinson's disease using an integrated strategy network pharmacology brain metabolomics.By integrating with metabolomic research, PD investigated transgenic mouse model for α-synuclein. metabolite level gene components that...
The Qiongdongnan Basin is located in the northwest of South China Sea,and deepwater area basin a new favorable prospect for hydrocarbon exploration.Based on seismic and bathymetric data,the authors focused this paper deep water topography control over sedimentation.Various landform types were distinguished their distribution pattern described.Discussed are also depositional mechanism gravity deposits types,distribution lithological characteristics,so as to reveal systems.Results show that...
Ménière's disease (MD), a common in the inner ear, is characterized by an increase endolymph cochlear duct and vestibular labyrinth. The pathophysiology of condition appears to be immune response. Studies have shown that basal levels IL-1β increased some MD patients. Here, we used murine model endolymphatic hydrops (EH) study effect anakinra on auditory function. Mice were intraperitoneal injected with or saline before LPS postauricular injection. Weight severity measured, histologic changes...
Human placenta was obtained from early onset preeclampsia, late and their gestational age-matched normal pregnancy. Using RT-qPCR, western blot, immunohistochemistry, it demonstrated that miR-21 expressions were significantly decreased in preeclampsia while RASA1 increased. Suppression of placental HTR-8/SVneo cells, remarkably upregulated RASA1, proliferation, inhibited invasion, promoted apoptosis trophoblast overexpression alleviated these effects. Dual-luciferase reporter assays revealed...
Objective: To investigate the prognostic factors of patients with low-frequency type sudden sensorineural hearing loss. Methods: From February 2017 to 2019, adult unilateral loss in Department Otological Medicine, Shandong Provincial ENT Hospital, University were selected. All examined by audiology, vestibular function evaluation, imaging examination and serum thyroid test; same treatment program was given, curative effect recorded followed up for more than 3 months. SPSS 20.0 software used...
Objective To analyze the characteristics of subjective visual horizontal （SVH） and evaluate its clinical value for vestibular function in peripheral unilateral hypofunction （UVH）. Methods Eighty-five patients with UVH （study group） 39 normal persons （control accepted tests, including SVH, vertical （SVV） caloric test by videonystagmography. The parameters angle SVH SVV, directional preponderance （DP） weakness（UW） were observed. correlation between SVH/SVV, DP, UW course disease...
To explore the association between thromboelastography and clinical features as well prognosis of sudden sensorineural hearing loss (SSNHL).Single-centre, retrospective study.A hospital in China.In total, 133 patients presented with SSNHL within 2 weeks before study, who did not receive treatment.The patients' medical history was collected. Audiological, imaging haematological examinations were performed treatment. Patients abnormal re-examined 1 week after treatment, efficacy evaluated...
Spag6 encodes an axoneme central apparatus protein that is required for normal flagellar and cilia motility. Recent findings suggest plays a role in hearing planar cell polarity (PCP) the cochlea of inner ear. However, vestibule has not yet been explored. In present study, function ear was examined using Spag6-deficient mice. Our results demonstrate vestibular disorder mutants, associated with abnormal ultrastructures hair cells Scarpa's ganglion cells, including swollen stereocilia,...
In this article, the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis human femoral head were investigated by imageological histological methods. Computed radiography (CR) computerized tomography (CT), common pathological section hard tissue analysis used to evaluated dynamics histopathological changes head, interface between host implant process. The results showed that density rods increased closed bones after 1 year implanting,...
This study described the care status of People Living with HIV (PLWH) including antiretroviral therapy (ART) and viral suppression from 2018 to 2020. We recognized that immediate ART was associated improved suppression. Therefore, we also aimed explore factors affecting early initiation ART. initiated a retrospective cohort evaluate people living in Shandong Province. From 2020, patients infected by homosexual transmission particular had higher rate (78.82%, 79.69%, 87.72%, respectively). Of...