A5100720185- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Platelet Disorders and Treatments
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Click Chemistry and Applications
- Cell Adhesion Molecules Research
- Genomics, phytochemicals, and oxidative stress
- Genetic Syndromes and Imprinting
- Kruppel-like factors research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Biomarkers in Disease Mechanisms
- Biosensors and Analytical Detection
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cancer, Lipids, and Metabolism
- Spondyloarthritis Studies and Treatments
- Autoimmune Bullous Skin Diseases
- Histone Deacetylase Inhibitors Research
- Essential Oils and Antimicrobial Activity
- Hippo pathway signaling and YAP/TAZ
- Lymphatic System and Diseases
- Inflammation biomarkers and pathways
Henan Agricultural University
2010-2025
Jilin Agricultural Science and Technology University
2025
Guangzhou University of Chinese Medicine
2024
Shengli Oilfield Central Hospital
2016-2024
Army Medical University
2024
University of Bonn
2024
Linyi University
2023
Tianjin Central Hospital of Gynecology Obstetrics
2018-2022
Nankai University
2018-2022
Jiangyin People's Hospital
2022
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at long-lived dauer diapause stage. daf-2 , a key gene in genetic pathway that mediates this endocrine signaling, encodes an insulin receptor family member. Decreases DAF-2 induce metabolic and developmental changes, as mammalian control by receptor. Decreased also causes increase life-span. Life-span regulation insulin-like is analogous to longevity enhancement...
Histone deacetylases (HDACs) are validated targets for anticancer therapy as attested by the approval of suberoylanilide hydroxamic acid (SAHA) and romidepsin (FK228) treating cutaneous T cell lymphoma. We recently described bioassay-guided isolation, structure determination, synthesis, target identification largazole, a marine-derived antiproliferative natural product that is prodrug releases potent HDAC inhibitor, largazole thiol. Here, we characterize activity using in vitro vivo cancer...
We show here that the lin-11 LIM homeobox gene is expressed in nine classes of head, ventral cord, and tail neurons functions at a late step development subset these neurons. In null mutant, all lin-11-expressing are generated. Several neurons, however, exhibit neuroanatomical as well functional defects. lateral head ganglion, neural network regulates thermosensory behavior. It AIZ interneuron processes high temperature input required for function thermoregulatory network. Another gene,...
High mobility group proteins (HMGs) are the second most abundant chromatin and exert global genomic functions in establishment of active or inactive domains. Through interaction with nucleosomes, transcription factors, nucleosome-remodeling machines histones, HMGs family contribute to fine tuning response rapid environmental changes. Mammalian high Bs (HMGBs) characterized by two tandem HMG box domains followed a long acidic tail. Recent studies demonstrated that expression HMGBs has been...
Abstract Krüppel‐like transcription factor (KLF) family is involved in tumorigenesis different types of cancer. However, the importance KLF gastric cancer unclear. Here, we examined gene expression five paired liver metastases and primary tissues by RT‐PCR, immunohistochemistry was used to study KLF8 206 samples. The impact on glycolysis, an altered energy metabolism that characterizes cells, evaluated. showed highest up‐regulation compared with tumours among all members. Higher associated...
Ultra-weak photon emission (UPE) is a noninvasive diagnostic tool that effectively reflects the function and health status of plant cells. However, current UPE measurement techniques are limited by resolution sensitivity, particularly when monitoring different species stress types. This study analyzes delayed luminescence (DL) properties Hydrocotyle vulgaris, Arabidopsis leaves, Ginkgo leaves under both control conditions using an independently developed imaging system. The results showed...
Endothelial cell injury and activation in the placenta are features of placental vascular disease (PVD). While advances PVD have been made, pathogenesis this is still unknown. The objective study was to pursue potential risk factors signal transcription pathways involved pathogenesis. Gene expression subjects with normal pregnancies compared using a two-channel microarray technique. Higher HSPA6 HSPA1A exhibited subjects. both encode HSP70, and, therefore, we localized HSP70 tissue. Using...
Bone marrow-derived endothelial progenitor cells (EPCs) contribute to neovessel formation in response growth factors, cytokines, and chemokines. Chemokine receptor CXCR2 its cognate ligands are reported mediate EPC recruitment angiogenesis. possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif which has been modulate cellular signaling functions. Here we examined the potential role of PDZ CXCR2-mediated motility We observed that exogenous C-tail significantly inhibited vitro migratory responses...
The aim of the present study was to investigate molecular mechanism associated with traditional Chinese medicine formula Gui Zhu Yi Kun (GZYKF), in treatment polycystic ovary syndrome (PCOS). In this study, granulosa cells (GCs) rats PCOS were cultured and treated testosterone propionate (TP) alone or serum from different doses GZYKF. effect TP on cell growth assayed using MTT method. Expression levels Beclin-1, light chain (LC)3, mechanistic target rapamycin (mTOR), tumor suppressor p53...
Preeclampsia is a complex multi-organ disease and the leading cause of maternofetal morbidity mortality. Low levels indoleamine 2,3-dioxygenase (IDO) diminished numbers regulatory T cells (Tregs) have been separately reported to participate in pathogenesis preeclampsia. In present study, we aimed determine whether alterations expression IDO, forkhead box P3 (Foxp3) interleukin-18 (IL-18) contribute preeclampsia, by measuring their preeclamptic placentae from healthy pregnant women as...
Chronic kidney disease is a common closely related to renal tubular inflammation and oxidative stress, no effective treatment available. Activation of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome an important factor in inflammation, but mechanism remains unclear. Micheliolide (MCL), which derived from parthenolide, new compound with antioxidative anti-inflammatory effects has multiple roles tumors inflammatory diseases. In this study, we...
In the previous study, we originally developed cancer stem cells (CSCs) models from mouse induced pluripotent (miPSCs) by culturing miPSCs in conditioned medium of cell lines, which mimiced as carcinoma microenvironment. However, molecular mechanism conversion detail remains to be uncovered. Microarray analysis CSCs this study revealed Dsg2, one members desmosomal cadherin family, was up-regulated when compared with original miPSCs. Moreover, expression key factors Wnt/β-catenin signaling...
Objective and importanceAcquired haemophilia is a rare hemorrhagic disease caused by inhibitory autoantibodies against coagulation factor VIII. Rituximab has become popular choice for immunosuppressive therapy in acquired haemophilia, almost with the same schedule of 375 mg/m2 per week 4–6 doses. While effect low-dose rituximab seldom been reported.Clinical presentationWe report patient, aged 88 years, who developed severe hemorrhage elevation carbohydrate antigen 125 (CA125), but absence...
Tetrathiatriarylmethyl (TAM, trityl) radicals have found wide applications in electron paramagnetic resonance (EPR) oximetry. However, the biomedical of TAM were exclusively limited to an extracellular region owing their negatively charged nature. The intracellular delivery still remains a challenge. In present work, we report liposome-based method encapsulate water-soluble Finland trityl radical CT-03 for its delivery. Using thin lipid film hydration method, CT-03-loaded liposomes prepared...
The risk of demand or production cost disruption is one the challenging problems in supply chain management. This paper explores a generalized game model incorporating possible disruptions. We find that nonlinear Grove wholesale price scheme can fully coordinate such even when both market and are disrupted. has three sides to decision behavior players. One mechanism induce retail pricing decided by dominant retailer be equal with channel; second fringe retailers not priced out market; third...