A5100411147- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Cancer-related gene regulation
- Pluripotent Stem Cells Research
- Molecular Sensors and Ion Detection
- Supramolecular Chemistry and Complexes
- Epigenetics and DNA Methylation
- Luminescence and Fluorescent Materials
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- Endometrial and Cervical Cancer Treatments
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- PI3K/AKT/mTOR signaling in cancer
- Signaling Pathways in Disease
- Advanced Breast Cancer Therapies
- Vascular Tumors and Angiosarcomas
- Biotin and Related Studies
- Supramolecular Self-Assembly in Materials
- Congenital heart defects research
- Fibroblast Growth Factor Research
- Intraperitoneal and Appendiceal Malignancies
Wuhan Institute of Technology
2024
Tianjin Central Hospital of Gynecology Obstetrics
2012-2024
Nankai University
2011-2024
Bristol-Myers Squibb (United States)
2016-2023
Chinese PLA General Hospital
2023
Chinese People's Liberation Army
2023
Bristol-Myers Squibb (Germany)
2023
Changhai Hospital
2023
Second Military Medical University
2023
Peking University Shenzhen Hospital
2021
Zinc metal anode shows promise as a candidate material for high-performance zinc-based batteries due to its high safety and low cost. However, the rampant growth of zinc dendrites occurrence...
Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues blood samples from 39 ESCC patients. The data revealed 12.8% ERBB4 mutations at patient level functional study supported its oncogenic role. 18% patients with early BRCA1/2 variants were associated high-level contribution signature 3, which was...
Cancer stem cells (CSCs) are capable of continuous proliferation and self-renewal proposed to play significant roles in oncogenesis, tumor growth, metastasis cancer recurrence. CSCs considered derived from normal affected by the microenvironment although mechanism development is not clear yet. In 2007, Yamanaka's group succeeded generating Nanog mouse induced pluripotent (miPS) cells, which green fluorescent protein (GFP) has been inserted into 5′-untranslated region gene. Usually, iPS just...
The elucidation of molecular events that confer tamoxifen resistance to estrogen receptor α (ER) positive breast cancer is major scientific and therapeutic importance. Here, we report LEM4 overexpression renders ER+ cells resistant by activating the cyclin D-CDK4/6 axis ERα signaling. We show accelerates tumor growth. Interaction with stabilizes CDK4 Rb, promotes Rb phosphorylation G1/S phase transition. depletion or combined PD0332991 treatment significantly reverses resistance....
GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation diverse cellular functions, including metabolism, differentiation, proliferation, and apoptosis. Inhibition may be useful treating number diseases Alzheimer's disease (AD), type II diabetes, mood disorders, some cancers, but approach poses significant challenges. Here, we present class isonicotinamides potent, highly kinase-selective inhibitors, members which demonstrated...
Tumor treating fields (TTF) is the latest treatment for GBM. Circular RNA (circRNA) has been demonstrated to play critical roles in tumorigenesis. However, molecular mechanism of TTF remained largely unknown and role circRNA was not reported. The aim this study elucidate circMMD GBM.Divergent primer designed verify existence GBM cells. prognostic explored glioma specimens. knockdown overexpressed plasmids were used evaluate effect on cell proliferation efficacy. pull-down immunoprecipitation...
Improving traditional crown ether to the water-soluble and high binding ability host molecule is critical our efforts model or mimic biological supramolecular systems. In this paper, we converted two ethers, 1,5-dinaphtho-32-crown-8 1,5-dinaphtho-38-crown-10, into tetrasulfonated evaluated their complexation with three dicationic bipyridiniums in aqueous solution by microcalorimetric titration, UV-vis, NMR experiments, then determined crystal structures of tetrasulfonatocrown...
An acceptor–donor–acceptor-type linear molecule 12+ containing one electron-rich naphthoxy (NP) unit and two monocharged viologen (MCV) units was synthesized. Through the noncovalent interaction of cucurbit[8]uril (CB[8]) with NP MCV in 12+, we first obtained a [2]pseudorotaxane ([12+]⊂CB[8]), excess CB[8] included simultaneously bare [2]pseudorotaxanes to form [5]pseudorotaxane ([12+]2⊂[CB[8]]3). Its transformation [3]pseudorotaxane achieved through detaching axle molecules presence acid,...
The highly affinitive and selective binding processes of tetrasulfonated 1,5-dinaphtho-38-crown-10 (14–) 1,5-dinaphtho-32-crown-8 (24–) with pyromellitic diimide naphthalene derivatives bearing cationic terminal groups (PMDI2+ NDI2+) are comprehensively investigated in aqueous solution by 1H NMR UV/vis experiments, mass spectrometry, microcalorimetric titration, crystallographic analysis. process host–guest complexation is thermodynamically driven the large enthalpic gain favorable entropic...
Abstract: Secreted frizzled-related proteins (SFRPs), the first identified Wnt antagonists, have been well recognized as tumor suppressors in multiple human cancers through suppressing Wnt/β-catenin pathway. To better elucidate mechanisms of SFRPs involved carcinogenesis oral submucous fibrosis (OSF), one precancerous lesions squamous cell carcinoma (OSCC), we investigated expression and localization SFRP1, SFRP5, β-catenin normal epithelium, OSF, OSCC tissues. We found that SFRP1 SFRP5 were...
A highly water-soluble crown ether bearing four sulfonate groups (1) was synthesized by sulfonation of neutral bis(m-phenylene)-26-crown-8. The complexation behavior 1 with two bispyridinium-based guests, methyl viologen (MV(2+)) and 1,2-bis(pyridinium)ethane (BPE(2+)), systematically investigated in both aqueous solution the solid state (1)H NMR spectroscopy, crystallography, microcalorimetry. crystallographic studies superstructures MV(2+)⊂1 BPE(2+)⊂1 show that MV(2+) forms an...
Chlorotoxin is a 36-amino acid peptide derived from Leiurus quinquestriatus (scorpion) venom, which has been shown to inhibit low-conductance chloride channels in colonic epithelial cells. also binds matrix metalloproteinase-2 and other proteins on glioma cell surfaces. Glioma cells are considered require the activation of during invasion migration. In this study, for targeting glioma, we designed two types recombinant chlorotoxin fused human IgG-Fcs with/without hinge region. was as dimer...
Targeting and down-regulation of ErbB2, a member EGF receptor family, is regarded as one the key aspect for cancer treatment because it often overexpressed in breast ovarian cells. Although natural ligands ErbB2 have not been found, unlike other ErbB receptors, EC-1, 20-amino acid circular peptide, has shown to bind an artificial ligand. Previously we showed EC-1 peptide did induce internalization SK-BR-3 In this report, designed divalent multivalent forms with Fc portion human IgG...
The cancer stem cell (CSC) hypothesis suggests that tumors are sustained exclusively by a small population of the cells with properties. CSCs have been identified in most and responsible for initiation, recurrence, resistance different cancers. In vitro CSC models will be great help revisiting mechanism development, as well tumor microenvironment heterogeneity metastasis. Our group recently described generation from induced pluripotent (iPSCs), which were reprogrammed normal cells, and/or...
In the previous study, we originally developed cancer stem cells (CSCs) models from mouse induced pluripotent (miPSCs) by culturing miPSCs in conditioned medium of cell lines, which mimiced as carcinoma microenvironment. However, molecular mechanism conversion detail remains to be uncovered. Microarray analysis CSCs this study revealed Dsg2, one members desmosomal cadherin family, was up-regulated when compared with original miPSCs. Moreover, expression key factors Wnt/β-catenin signaling...
Abstract Gastric cancer remains one of the most prevalent tumors worldwide and peritoneal metastasis is responsible for approximately 60% death in advanced gastric patients. However, underlying mechanism poorly understood. We have established organoids derived from malignant ascites (MA) patients noticed that MA supernatant could strongly increase colony formation organoids. Thus, we realized interaction between exfoliated cells (ECCs) liquid tumor microenvironment contributes to metastasis....
Abstract Generally angiogenic factors induce the expression of E‐selectin in vascular endothelial cells tumors. In this study, we employed an anti‐E‐selectin monoclonal antibody to target tumors vivo and evaluated optical imaging reagent visualize tumor regions. The was conjugated on surface liposomes, which encapsulated near‐infrared fluorescent substances Cy3 or Cy5.5. liposomes efficiently recognized human umbilical vein only when induced by such as TNF‐ α vitro . Cy5.5 into that were...
Precise cytological diagnosis of pelvic high-grade serous carcinoma (HGSC) in ascites is important for tumour staging, therapeutic decision-making and prognostic evaluation. However, it can often be difficult to distinguish metastatic HGSC cells from reactive mesothelial based on morphology alone. Immunocytochemical analysis cell blocks has been used obtain accurate provide a reliable basis treatment decisions the clinic. This study was performed determine whether panel antibodies necessary...
<b><i>Objective:</i></b> This study investigates the synergistic effects of Gleevec (imatinib) and rapamycin on proliferative angiogenic properties mouse bone marrow-derived endothelial progenitor cells (EPCs). <b><i>Materials Methods:</i></b> EPCs were isolated from marrow treated with different concentrations or individually in combination. The cell viability proliferation examined using MTT assay. An analysis cycle apoptosis was performed...
Objective. This investigation aimed to figure out the relation between discs large homolog 3 (DLG3) expression and progression prognosis of breast cancer (BC). Methods. qRT-PCR was utilized for confirming DLG3 RAC1 mRNA in BC tissues cells. Subsequently, after overexpression or interference DLG3, changes biological activities cells, including cell proliferation, migration, invasion, apoptosis, were detected through CCK-8, colony formation assay, wound healing transwell flow cytometry,...