A5013651801- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Traumatic Brain Injury and Neurovascular Disturbances
- Extracellular vesicles in disease
- Genetic factors in colorectal cancer
- Endoplasmic Reticulum Stress and Disease
Xiangya Hospital Central South University
2016-2025
Central South University
2016-2025
Nanjing Medical University
2021-2025
Nantong University
2022-2025
Henan University of Urban Construction
2025
Zhongshan Hospital of Xiamen University
2025
Kunming Medical University
2022-2025
Taizhou People's Hospital
2025
Hangzhou First People's Hospital
2024
Jiangsu Province Hospital
2021-2024
Gliomas are one of the most common types primary tumors in central nervous system. Previous studies have found that macrophages actively participate tumor growth.Weighted gene co-expression network analysis was used to identify meaningful macrophage-related genes for clustering. Pamr, SVM, and neural were applied validating clustering results. Somatic mutation methylation defining features identified clusters. Differentially expressed (DEGs) between stratified groups after performing elastic...
With the increasing use of immune checkpoint inhibitors (ICIs) for tumour immunotherapy, immune-related adverse events (irAEs) caused by their collateral effect on system pose a key challenge clinical application ICIs. Psychiatric are class associated with ICIs that realistically observed in real world. We aim to provide comprehensive study and summary psychiatric ICIs.We obtained ICI reaction reports during January 2012-December 2021 from FDA Adverse Event Reporting System (FAERS) database....
Abstract Immune checkpoint inhibitors (ICIs) have completely changed the approach pertaining to tumor diagnostics and treatment. Similarly, immunotherapy has also provided much needed data about mutation, expression prognosis, affording an unprecedented opportunity for discovering candidate drug targets screening immunotherapy-relevant biomarkers. Although existing web tools enable biologists analyze expression, mutation prognostic of tumors, they are currently unable facilitate mining...
Rationale: Accumulating evidence demonstrated that long noncoding RNAs (lncRNAs) involved in the regulation of immune system and displayed a cell-type-specific pattern cell subsets. Given vital role tumor-infiltrating lymphocytes effective immunotherapy, we explored cell-associated lncRNA (TIIClncRNA) low-grade glioma (LGG), which has never been uncovered yet. Methods: This study utilized novel computational framework 10 machine learning algorithms (101 combinations) to screen out...
Abstract Data mining from RNA-seq or microarray data has become an essential part of cancer biomarker exploration. Certain existing web servers are valuable and broadly utilized, but the meta-analysis multiple datasets is absent. Most only contain tumor samples TCGA database with one cohort for each type, which also means that analysis results mainly derived a single thin unstable. Indeed, consistent performance across independent cohorts foundation excellent biomarker. Moreover, deeper...
Cytotoxic T lymphocytes (CTLs) play critical antitumor roles, encompassing diverse subsets including CD4+, NK, and γδ cells beyond conventional CD8+ CTLs. However, definitive CTLs biomarkers remain elusive, as cytotoxicity-molecule expression does not necessarily confer cytotoxic capacity. differentiation involves transcriptional regulation by factors such T-bet Blimp-1, although epigenetic of is less clear. promote tumor killing through granules death receptor pathways, but may also...
Abstract Background Epidemiological evidence links a close correlation between long-term exposure to air pollutants and autoimmune diseases, while the causality remained unknown. Methods Two-sample Mendelian randomization (TSMR) was used investigate role of PM10, PM2.5, NO 2 , X (N = 423,796–456,380) in 15 diseases 14,890–314,995) using data from large European GWASs including UKB, FINNGEN, IMSGC, IPSCSG. Multivariable (MVMR) conducted direct effect each pollutant mediating common factors,...
The FDA's alerts regarding the T-cell lymphoma risk post CAR-T therapy has garnered global attention, yet a comprehensive profile of second primary malignancies (SPMs) following treatment is lacking.