Jian Chen

ORCID: 0009-0009-9327-875X
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Research Areas
  • Neonatal Respiratory Health Research
  • Pediatric health and respiratory diseases
  • Chronic Kidney Disease and Diabetes
  • Anesthesia and Sedative Agents
  • Tuberculosis Research and Epidemiology
  • Anesthesia and Pain Management
  • Congenital Diaphragmatic Hernia Studies
  • Neuroscience of respiration and sleep
  • Respiratory Support and Mechanisms
  • Trigeminal Neuralgia and Treatments
  • Neonatal and fetal brain pathology
  • Airway Management and Intubation Techniques
  • Renal Diseases and Glomerulopathies
  • Mycobacterium research and diagnosis
  • Neurosurgical Procedures and Complications
  • Trauma and Emergency Care Studies
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Traditional Chinese Medicine Analysis
  • Shoulder Injury and Treatment
  • Cervical and Thoracic Myelopathy
  • Anesthesia and Neurotoxicity Research
  • Cardiac, Anesthesia and Surgical Outcomes
  • Trauma Management and Diagnosis
  • Meat and Animal Product Quality
  • Nanocomposite Films for Food Packaging

Institute of Botany
2025

Nanjing Medical University
2021-2024

Second Affiliated Hospital of Nanjing Medical University
2010-2024

Hangzhou Medical College
2016-2024

Chinese PLA General Hospital
2021-2024

Kunming Medical University
2023

Tongde Hospital of Zhejiang Province
2021

Huangshi Central Hospital
2021

Hubei Polytechnic University
2021

Jiangsu Province Hospital
2021

Abstract Objective Employing whole‐exome sequencing (WES) technology to investigate the etiology of infantile epileptic spasm syndrome (IESS), and determining whether different etiologies exhibit phenotypic variations, while elucidating potential associated factors, might improve short‐term responses first‐line treatment. Methods We retrospectively evaluated patients with IESS admitted for treatment between January 2018 June 2023. Clinical differences among etiological classifications...

10.1002/acn3.52125 article EN cc-by-nc-nd Annals of Clinical and Translational Neurology 2024-06-10

Preserving fresh meat has been a long-standing challenge due to microbial growth and lipid oxidation. In this study, chitosan (CS) active coatings loaded with blackberry anthocyanins (BA), tea polyphenols (TP), their combination, designated as CS/BA, CS/TP, CS/BA/TP, were applied for chilled pork preservation. Compared CS coating alone, CS/BA/TP exhibited 9.3% lower total viable count (TVC), 45.5% reduction in thiobarbituric acid reactive substances (TBARS), 26.6% decrease volatile basic...

10.3389/fnut.2025.1546618 article EN cc-by Frontiers in Nutrition 2025-05-07

Background: Limited data are available for the diagnostic value, and sensitivity specificity of joint detection serum lactate dehydrogenase (sLDH)/ pleural fluid adenosine deaminase (pADA) carcinoembryonic antigen (pCEA) in malignant effusion (MPE). Methods:We collected 987 specimens (of which 318 were effusion, 374 tubercular 295 parapneumonic specimens) from First Affiliated Hospital Wenzhou Medical University July 2012 to March 2016.The pADA, sLDH, LDH (pLDH), C-reactive protein (sCRP),...

10.1002/jcla.22106 article EN Journal of Clinical Laboratory Analysis 2016-12-15

Chronic kidney disease accounts for much of the increased mortality, especially in elder population. The prevalence this is expected to increase significantly as society ages. Our aim was evaluate function and risk factors reduced renal among elderly Chinese patients. This study retrospectively collected clinical data from a total 1062 inpatients aged 65 years or over. Estimated glomerular filtration rate (eGFR) calculated with Kidney Disease Epidemiology Collaboration (CKD-EPI) equation....

10.3109/0886022x.2015.1068513 article EN Renal Failure 2015-07-27

BACKGROUND Dopamine agonists (DAs) are the first-line treatment for prolactinomas. DAs primarily target dopamine D2 receptor (D2R). Tumor stem-like cells (TSLCs) associated with tolerance to radiotherapy and chemotherapy. TSLCs have also been identified in pituitary adenomas. We aimed characterize expression pattern of stem cell markers D2R human rat MATERIAL AND METHODS Human prolactinoma specimens (n=14) were obtained from patients surgical resection. The xenograft model prolactinomas was...

10.12659/msm.901154 article EN Medical Science Monitor 2017-04-15

Abstract Previous studies have explored the relationship between homocystein (Hcy) and lipid profiles. However, results from these been inconsistent. The current study investigated correlation Hcy profiles in Chinese community‐based population. participants were composed of 4012 people aged 30–92 years old, who recruited rural urban communities Hunan Province. Non‐parametric test logistic regression used to examine distribution (triglyceride [TG], total cholesterol [TC], low‐density...

10.1002/lipd.12279 article EN Lipids 2020-09-21

Burst suppression (BS) is a specific electroencephalogram (EEG) pattern that may contribute to postoperative delirium and negative outcomes. Few prediction models of BS are available some factors such as frailty intraoperative hypotension (IOH) which have been reported promote the occurrence were not included. Therefore, we look forward creating straightforward, precise, clinically useful model by incorporating new factors, IOH.

10.1080/07853890.2024.2407067 article EN cc-by-nc Annals of Medicine 2024-09-24

Tumor necrosis factor (TNF)-α has an important role in the pathogenesis of autoimmune and inflammatory diseases such as rheumatoid septic arthritis. Removal excess tumor factor-α (TNF-α) is a promising treatment. In this study, series functionalized carbon nanotube-embedded poly(vinyl alcohol) (PVA) nanocomposite adsorbents were prepared for TNF-α removal first time. The resulting nanocomposites characterized by scanning electron microscopy Raman spectroscopy, which demonstrated that...

10.1021/acsbiomaterials.9b01916 article EN ACS Biomaterials Science & Engineering 2020-06-24

Diabetic nephropathy (DN) is a common and severe complication of diabetes, impacting millions people worldwide. High concentrations serum glucose-associated injury renal glomerular endothelial cells (rGECs) are involved in the DN pathogenesis. We found that exposure to high glucose increased expression angiotensin II type 1 receptor (AT1R) human rGECs (hrGECs). To block AT1R level, we used newly developed antagonist Telmisartan. This study investigated whether Telmisartan possessed...

10.1021/acs.chemrestox.1c00159 article EN Chemical Research in Toxicology 2021-08-31

To investigate the clinical features of infancy traumatic brain injury (TBI) and prognostic value Trauma Infant Neurologic Score (TINS), infants <2 years age with TBI who were admitted from 2000 to 2007 retrospectively studied. Fifty-six patients a mean 13.3 ± 6.5 months (range = 2–24) identified. The diagnoses, in terms severest injury, included scalp hematomas (n 2), skull bone fractures 3), epidural 21), subdural 14), cerebral contusion laceration 4), intracerebral 7), subarachnoid...

10.1159/000321800 article EN Pediatric Neurosurgery 2010-01-01

Vagus nerve stimulation (VNS) has been demonstrated to be safe and effective for patients with refractory epilepsy, but there are few reports on the use of VNS postencephalitic epilepsy (PEE). This retrospective study aimed evaluate efficacy PEE. We retrospectively studied 20 PEE who underwent between August 2017 October 2019 in Chinese PLA General Hospital Beijing Children's Hospital. was evaluated based seizure reduction, rate (percentage cases reduction ≥ 50%), McHugh classification,...

10.3389/fnins.2021.685685 article EN cc-by Frontiers in Neuroscience 2021-08-19

Abstract Background Oxidative stress-induced injury during hypothermic preservation is a universal problem that delays graft function and decrease the success of organ transplantation. Tanshinone IIA (Tan IIA) was reported to exhibit variety biochemical activities, including protection against oxidative stress. Therefore, specific molecular pathway by which Tan protects renal tissues investigated in this study. Methods In vivo study, Sprague-Dawley (SD) rats were divided into twelve groups...

10.1186/s12906-021-03427-7 article EN cc-by BMC Complementary Medicine and Therapies 2021-10-08

Objective To research the factors that affect efficacy of 2 826 cases trigeminal neuralgia after microvascular decompression follow - up more than 1 year.Method 25 years ( mean 9.8 years) were followed for patients with from January 1984 to 2009.Results The long term cure rate was 86.8%,markedly effective 4.5%,efficiency 2.0%,inefficiency 1.6%.Pain recurrence 5.1%,remaining complication 7.0%,subjective satisfaction equal or greater 80% accounted 85.2%,satisfaction less 14.8%.Conclusions...

10.3760/cma.j.issn.1001-2346.2011.05.006 article EN Zhonghua shenjing waike zazhi 2011-05-28

Objective To explore the change of early stage coagulation function newborn baby recovery from stifle and its clinical significance.Methods 120 asphyxial neonates were selected randomly as research subjects.The DD,PC,PLT,PT,APTT,TT Fg detected compared with normal baby.Results The statistical analysis showed that DD (t =17.65,P < 0.01),PC =7.22,P 0.01),PLT (tsevere =10.95,P 0.01 ;tmild=4.12,P<0.01),PT(tsevers =13.01,P<0.01;tmild =8.09,P <0.01),APTT(tsevers =12.70,P <0.01 ;tmild =8.53,P...

10.3760/cma.j.issn.1008-6706.2014.11.015 article EN 2014-06-01

Objective To study the pathogen distribution and treatment strategies of chronic obstructive pulmonary disease (COPD) complicated with infection (PI).Methods One hundred six cases COPD patients PI from April 2010 to December 2012 in our hospital were selected as observation objects,and randomly divided into group control group,each had 53 cases.Observation given sputum culture drug sensitivity test,according sensitive test results symptomatic medication.Control according clinical experience...

10.3760/cma.j.issn.1673-436x.2014.05.008 article EN Chinese Journal of Asthma 2014-03-05
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