A5078343111- Pulmonary Hypertension Research and Treatments
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Eicosanoids and Hypertension Pharmacology
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Esophageal Cancer Research and Treatment
- High Altitude and Hypoxia
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Protease and Inhibitor Mechanisms
- Ion Channels and Receptors
- Bladder and Urothelial Cancer Treatments
- Neonatal Respiratory Health Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Postharvest Quality and Shelf Life Management
- Respiratory Support and Mechanisms
- Autophagy in Disease and Therapy
Shenzhen Second People's Hospital
2019-2025
Shandong First Medical University
2020-2025
Shandong Tumor Hospital
2025
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2025
Shandong University of Traditional Chinese Medicine
2025
Tang Du Hospital
2025
Shandong Provincial QianFoShan Hospital
2022-2024
Sun Yat-sen University
2020-2024
Sun Yat-sen University Cancer Center
2020-2024
Hebei Medical University
2022-2024
Abstract The COVID-19 pandemic has accounted for millions of infections and hundreds thousand deaths worldwide in a short-time period. patients demonstrate great diversity clinical laboratory manifestations disease severity. Nonetheless, little is known about the host genetic contribution to observed interindividual phenotypic variability. Here, we report first study Chinese population by deeply sequencing analyzing 332 categorized varying levels severity from Shenzhen Third People’s...
Bleomycin exhibits effective chemotherapeutic activity against multiple types of tumors, and also induces various side effects, such as pulmonary fibrosis neuronal defects, which limit the clinical application this drug. Macroautophagy/autophagy has been recently reported to be involved in functions bleomycin, yet mechanisms their crosstalk remain insufficiently understood. Here, we demonstrated that reactive oxygen species (ROS) produced during bleomycin activation hampered autophagy flux...
Lung cancer is an extremely heterogeneous disease, and its treatment remains one of the most challenging tasks in medicine. Few existing laboratory lung models can faithfully recapitulate diversity disease predict therapy response. Here, we establish 12 patient-derived organoids from common subtype, adenocarcinoma (LADC). Extensive gene histopathology profiling show that tumor retain histological architectures, genomic landscapes, expression profiles their parental tumors. Patient-derived...
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks especially in those patients without comorbidities, not fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude with selected yet symptoms ranging asymptomatic critically ill. Using integrative analysis genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, report...
Resveratrol, a plant-derived polyphenolic compound and phytoestrogen, was shown to possess multiple protective effects including anti-inflammatory response anti-oxidative stress. Hypoxic pulmonary hypertension (HPH) is progressive disease characterized by sustained vascular resistance marked remodeling. The exact mechanisms of HPH are still unclear, but inflammatory oxidative stress demonstrated participate in the progression HPH. present study designed investigate resveratrol on...
It is well established that hypoxia induces epithelial‑mesenchymal transition in vitro and vivo. However, the role of endothelial‑mesenchymal (EndMT), an important process pathogenesis pulmonary hypertension, not well‑characterized. The present study demonstrated a significant downregulation endothelial marker CD31 its co‑localization with mesenchymal marker, α‑smooth muscle actin (α‑SMA), intimal layer small arteries rats exposed to chronic hypoxia. These results suggest possible inducing...
Abstract Objectives Recent advances in patient‐derived cancer organoids have opened a new avenue for personalised medicine. We aimed to establish an vitro technological platform evaluate chimeric antigen receptor (CAR)‐T cell‐mediated cytotoxicity against bladder cancer. Methods Patient‐derived (BCOs) were derived using classic medium containing R‐spondin 1 and noggin. The features of BCOs characterised via H&E, whole‐exome sequencing immunofluorescence specific markers. Surface...
Abstract Background Kidney cancer is one of the most common solid tumors. The advancement human kidney research and treatment has been hindered by a lack models that faithfully recapitulate diversity disease. Methods We established an effective three‐dimensional culture system for generating organoids from clinical renal cell carcinoma samples. Renal (RCC) were characterized H&E staining, immunofluorescence, whole‐exome sequencing, RNA sequencing single‐cell sequencing. use RCC in...
Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift how increased promotes hypoxic artery smooth muscle cell (PASMC) proliferation vascular remodeling remain elusive. Here, we reported that hypoxia-induced inhibit HIF-1α hydroxylation further trigger PASMC switch through upregulated HIF-1α/PDK1&PDK2/p-PDH-E1α axis, which facilitates lactate accumulation histone...
Since 2020, clade 2.3.4.4b highly pathogenic avian influenza H5N8 and H5N1 viruses have swept through continents, posing serious threats to the world. Through comprehensive analyses of epidemiological, genetic, bird migration data, we found that dominant genotype replacement in 2020 contributed outbreak 2021/2022 wave. The G1 instead G0 produced reassortment opportunities led emergence a new virus with G1's HA MP genes. Despite extensive reassortments wave, retained genes, causing...
Abstract Ginger (Zingiber officinale) is one of the most valued spice plants worldwide; it prized for its culinary and folk medicinal applications therefore high economic cultural importance. Here, we present a haplotype-resolved, chromosome-scale assembly diploid ginger anchored to 11 pseudochromosome pairs with total length 3.1 Gb. Remarkable structural variation was identified between haplotypes, two inversions larger than 15 Mb on chromosome 4 may be associated infertility. We performed...
Abstract Sex determination systems in plants can involve either female or male heterogamety (ZW XY, respectively). Here we used Illumina short reads, Oxford Nanopore Technologies (ONT) long reads and Hi‐C to assemble the first chromosome‐scale genome of a willow tree ( Salix dunnii ), predict genes using transcriptome sequences available databases. The final sequence 328 Mb total was assembled 29 scaffolds, includes 31,501 predicted genes. Analyses short‐read data that included suggested...
Abstract Context Papillary thyroid cancer (PTC) has been one of the most frequent endocrine malignancies around world. Although PTC patients have a favorable prognosis, subgroup die, especially when disease recurrence occurs. There is pressing need for clinically relevant preclinical models personalized therapy because lack in vitro that faithfully represent biology parental tumors. Objective To understand and translate this knowledge to clinical applications, patient-derived organoids as...
Abstract Polyploidization plays a key role in plant evolution, but the forces driving fate of homoeologs polyploid genomes, i.e., paralogs resulting from whole-genome duplication (WGD) event, remain to be elucidated. Here, we present chromosome-scale genome assembly tetraploid scarlet sage ( Salvia splendens ), one most diverse ornamental plants. We found evidence for three WGD events following an older event shared by eudicots (the γ event). A comprehensive, spatiotemporal, genome-wide...
Background Conflicting findings have been reported regarding the association between STK11/LKB1 mutations and immune checkpoint inhibitor (ICB) efficacy in NSCLC. It has demonstrated that tumors could exhibit impaired function even without STK11 mutations. We hypothesized deficient phenotype rather than mutation may better stratify ICB outcomes. Methods Selected functional events LKB1 protein data were leveraged to establish a transcriptomics-based classifier of (STK11 -deficient or...
With a worldwide prevalence of ~5%, attention deficit hyperactivity disorder (ADHD) has become one the most common psychiatric disorders. The polygenetic nature ADHD indicates that multiple genes jointly contribute to development this complex disease. Studies aiming explore genetic susceptibility have been increasing in recent years. There is growing need integrate data from various studies provide comprehensive set and uniform access for convenience in-depth mining. So far, there no such...
Activation of pulmonary adventitial fibroblasts plays a key role in the vascular remodeling hypoxic hypertension. Previous studies showed that miRNAs participated regulation fibroblast activation. This study explored miR-29 activation and therapeutic potential We found hypoxia-induced was accompanied with drastic decrease miR-29a-3p expression. Knockdown hypoxia-inducible factor-1 α or Smad3 reversed miR-29-3p cultured fibroblasts. In vitro, mimic inhibited proliferation, migration,...
We previously showed that tanshinone IIA ameliorated the hypoxia-induced pulmonary hypertension (HPH) partially by attenuating artery remodeling. The proliferation of smooth muscle cells (PASMCs) is one major causes for arterial remodeling, therefore present study was performed to explore effects and underlying mechanism on PASMCs proliferation. were isolated from male Sprague-Dawley rats cultured in normoxic (21%) or hypoxic (3%) condition. Cell measured with 3 - (4, 5 dimethylthiazal 2 yl)...
Pulmonary fibrosis (PF) is a common complication in those interstitial lung diseases patients, which will result poor prognosis and short survival.Traditional therapeutic methods such as glucocorticoid cytotoxic drugs are insufficient for treating PF may cause severe side effects.Recent studies showed that traditional Chinese herbal abstraction Tanshinone IIA (TIIA) was displayed significant anti-PF effects animal models.However, the exact mechanisms underlying protective of TIIA were not...