A5100370590- Gut microbiota and health
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- T-cell and B-cell Immunology
- Reproductive tract infections research
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Diet and metabolism studies
- Pelvic floor disorders treatments
- SARS-CoV-2 and COVID-19 Research
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Clostridium difficile and Clostridium perfringens research
- Urinary Tract Infections Management
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Metabolomics and Mass Spectrometry Studies
- Oral microbiology and periodontitis research
- Genomic variations and chromosomal abnormalities
- Genetic Mapping and Diversity in Plants and Animals
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Genetic diversity and population structure
- COVID-19 Clinical Research Studies
China National GeneBank
2016-2025
BGI Group (China)
2016-2025
International Peace Maternity & Child Health Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
BGI Research
2024-2025
Jiangnan University
2025
Wuxi Fourth People's Hospital
2025
Shandong Jiaotong University
2025
Shandong University
2024
Southern Medical University
2024
Insects are the most speciose group of animals, but phylogenetic relationships many major lineages remain unresolved. We inferred phylogeny insects from 1478 protein-coding genes. Phylogenomic analyses nucleotide and amino acid sequences, with site-specific or domain-specific substitution models, produced statistically robust congruent results resolving previously controversial relations hips. dated origin to Early Ordovician [~479 million years ago (Ma)], insect flight Devonian (~406 Ma),...
No Genetic Vertigo Peoples living in high altitudes have adapted to their situation (see the Perspective by Storz ). To identify gene regions that might contributed high-altitude adaptation Tibetans, Simonson et al. (p. 72 , published online 13 May) conducted a genome scan of nucleotide polymorphism comparing Han Chinese, and Japanese, while Yi 75 ) performed comparable analyses on coding all genes—their exomes. Both studies converged gene, endothelial Per-Arnt-Sim domain protein 1 (also...
The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of microbiome in relation diseases have not systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic disease (ACVD) 187 healthy controls. ACVD deviates status by increased abundance Enterobacteriaceae Streptococcus spp. and, functionally, potential for metabolism or transport several molecules important...
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view current methodologies precludes their systematic application analyze relatively large three-dimensional mid- late-gestation embryos. Here, we combined DNA nanoball (DNB)-patterned arrays in situ RNA capture create spatial enhanced resolution omics-sequencing (Stereo-seq). We applied...
Mapping the mammalian brain The diverse physiology of is reflected in its complex organization at regional, cellular, and subcellular levels. Sjöstedt et al. combined data—both newly acquired from other large-scale mapping projects—from transcriptomics, single-cell genomics, situ hybridization, antibody-based protein profiling to map molecular profiles human, pig, mouse brain. analysis consistent with a conserved basic architecture during evolution, but it does show differences regional gene...
Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond vagina has been a matter of debate. Here we systematically sample microbiota within 110 women age, examine nature colonisation by 16S rRNA gene amplicon sequencing cultivation. We find cervical canal, uterus, fallopian tubes peritoneal fluid, differing from that vagina. The results reflect...
Completion of genome sequences for the diploid Setaria italica reveals features C4 photosynthesis that could enable improvement polyploid biofuel crop switchgrass (Panicum virgatum). The genetic basis biotechnologically relevant traits, including drought tolerance, photosynthetic efficiency and flowering control, is also highlighted. Foxtail millet (Setaria italica), a member Poaceae grass family, an important food fodder in arid regions has potential use as biofuel. It model system other...
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet molecular basis hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study 88 matched HCC tumor/normal pairs, 81 which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes pathways implicated in HBV-associated HCC. We find beta-catenin be frequently mutated oncogene (15.9%) TP53 tumor suppressor...
The brown planthopper, Nilaparvata lugens, the most destructive pest of rice, is a typical monophagous herbivore that feeds exclusively on rice sap, which migrates over long distances. Outbreaks it have re-occurred approximately every three years in Asia. It has also been used as model system for ecological studies and developing effective management. To better understand how sap-sucking arthropod adapted to its exclusive host selection provide insights improve control, we analyzed genomes...
Robin Gasser and his colleagues report the whole-genome sequence of Schistosoma haematobium. They include comparisons to genome sequences S. mansoni japonicum, two other species that cause schistosomiasis in humans. Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) affecting 200 million people worldwide1. No vaccines are available, treatment relies on one drug, praziquantel2. haematobium has come into spotlight as major urogenital...
An emerging cavefish model, the cyprinid genus Sinocyclocheilus, is endemic to massive southwestern karst area adjacent Qinghai-Tibetan Plateau of China. In order understand whether orogeny influenced evolution these species, and how genomes change under isolation, especially in subterranean habitats, we performed whole-genome sequencing comparative analyses three species this genus, S. grahami, rhinocerous anshuiensis. These are surface-dwelling, semi-cave-dwelling cave-restricted,...
Abstract Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic data from treatment-naïve patients are scarce hampering comprehensive analyses of complex interaction between gut microbiota and brain. Here we explore fecal microbiome based on 90 medication-free schizophrenia 81 controls identify microbial species classifier distinguishing with...
Abstract The root microbes play pivotal roles in plant productivity, nutrient uptakes, and disease resistance. microbial community structure has been extensively investigated by 16S/18S/ITS amplicons metagenomic sequencing crops model plants. However, the functional associations between host growth are poorly understood. This work investigates bacterial of foxtail millet (Setaria italica) its potential effects on productivity. We determined composition 2882 samples from rhizoplane,...
Ginkgo biloba L. (Ginkgoaceae) is one of the most distinctive plants. It possesses a suite fascinating characteristics including large genome, outstanding resistance/tolerance to abiotic and biotic stresses, dioecious reproduction, making it an ideal model species for biological studies. However, lack high-quality genome sequence has been impediment our understanding its biology evolution.The 10.61 Gb containing 41,840 annotated genes was assembled in present study. Repetitive sequences...
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with discovery of molecular signatures stress, some which include alterations an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between stress-related disease, major depression, and amount mtDNA (p = 9.00 × 10(-42), odds ratio 1.33 [95% confidence interval [CI] 1.29-1.37]) telomere length 2.84 10(-14), 0.85 CI...