A5100774874- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Bioinformatics and Genomic Networks
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Geological and Geochemical Analysis
- Cancer Mechanisms and Therapy
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Multiple Myeloma Research and Treatments
- Head and Neck Cancer Studies
- Gene expression and cancer classification
- Renal cell carcinoma treatment
- Gene Regulatory Network Analysis
- earthquake and tectonic studies
- Single-cell and spatial transcriptomics
- Machine Learning in Bioinformatics
- Geochemistry and Geologic Mapping
- Protease and Inhibitor Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Nanchang University
2014-2025
First Affiliated Hospital of Jiangxi Medical College
2025
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2025
Guangzhou University of Chinese Medicine
2025
Shandong University
2021-2024
Shandong Provincial Hospital
2021-2024
Ministry of Agriculture and Rural Affairs
2024
Army Medical University
2008-2024
Guangdong Academy of Medical Sciences
2024
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet molecular basis hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study 88 matched HCC tumor/normal pairs, 81 which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes pathways implicated in HBV-associated HCC. We find beta-catenin be frequently mutated oncogene (15.9%) TP53 tumor suppressor...
Abstract Pyroptosis, a form of programmed cell death (PCD), has garnered increasing attention as it relates to innate immunity and diseases. However, the involvement pyroptosis in mechanism by which lobaplatin acts against colorectal cancer (CRC) is unclear. Our study revealed that treatment with reduced viability HT-29 HCT116 cells dose-dependent manner. Morphologically, treated exhibited microscopic features swelling large bubbles emerging from plasma membrane, transmission electron...
Assembly of a transcriptional and post‐translational molecular interaction network in B cells, the human B‐cell interactome (HBCI), reveals hierarchical, control module, where MYB FOXM1 act as synergistic master regulators proliferation germinal center (GC). Eighty percent genes jointly regulated by these transcription factors are activated GC, including those encoding proteins complex regulating DNA pre‐replication, replication, mitosis. These results indicate that HBCI analysis can be used...
We introduce novel profile-based string kernels for use with support vector machines (SVMs) the problems of protein classification and remote homology detection. These probabilistic profiles, such as those produced by PSI-BLAST algorithm, to define position-dependent mutation neighborhoods along sequences inexact matching k-length subsequences ("k-mers") in data. By an efficient data structure, are fast compute once profiles have been obtained. For example, time needed run order build is...
Abstract Motivation: An increasingly common application of gene expression profile data is the reverse engineering cellular networks. However, procedures to normalize profiles generated using Affymetrix GeneChips technology were originally developed for a rather different purpose, namely accurate measure differential between two or more phenotypes. As result, current evaluation strategies lack comprehensive metrics assess suitability available normalization and, in general, measuring...
Abstract Using expression profiles from postmortem prefrontal cortex samples of 624 dementia patients and non‐demented controls, we investigated global disruptions in the co‐regulation genes two neurodegenerative diseases, late‐onset Alzheimer's disease ( AD ) Huntington's HD ). We identified networks differentially co‐expressed DC gene pairs that either gained or lost correlation cases relative to control group, with former dominant for both patterns replicating independent human cohorts...
Cancer is a genetic disease with frequent somatic DNA alterations. Studying recurrent copy number aberrations (CNAs) in human cancers would enable the elucidation of mechanisms and prioritization candidate oncogenic drivers causal roles oncogenesis. We have comprehensively systematically characterized CNAs accompanying gene expression changes tumors matched nontumor liver tissues from 286 hepatocellular carcinoma (HCC) patients. Our analysis identified 29 recurrently amplified 22 deleted...
Patients with Type 1 Diabetes (T1D) are particularly vulnerable to development of Diabetic nephropathy (DN) leading End Stage Renal Disease. Hence a better understanding the factors affecting kidney disease progression in T1D is urgently needed. In recent years microRNAs have emerged as important post-transcriptional regulators gene expression many different health conditions. We hypothesized that urinary microRNA profile patients will differ stages diabetic renal disease.We studied urine...
To identify and characterize novel, activating mutations in Notch receptors breast cancer to determine response the gamma secretase inhibitor (GSI) PF-03084014.We used several computational approaches, including novel algorithms, analyze next-generation sequencing data related omic datasets from The Cancer Genome Atlas (TCGA) cohort. Patient-derived xenograft (PDX) models were sequenced, Notch-mutant treated with PF-03084014. Gene-expression functional analyses performed study mechanism of...
Abstract Background One of the major reasons for poor prognosis pancreatic cancer is its high resistance to currently available chemotherapeutic agents. In recent years, focal adhesion kinase (FAK), a central molecule in extracellular matrix (ECM)/integrin-mediated signaling, has been thought be key determinant chemoresistance cells. this study, we aimed determine roles FAK phosphorylation intrinsic cell lines. Results Our results showed that, level constitutive at Tyr397 correlated with...
Abstract Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. A number of molecular profiling studies have investigated changes in gene and protein expression that are associated with various clinicopathological characteristics HCC generated a wealth scattered information, usually form signature tables. database published signatures would be useful to liver researchers seeking retrieve existing differential information on candidate make comparisons between for...
To develop a comprehensive overview of copy number aberrations (CNAs) in stage-II/III colorectal cancer (CRC), we characterized 302 tumors from the PETACC-3 clinical trial. Microsatellite-stable (MSS) samples (n = 269) had 66 minimal common CNA regions, with frequent gains on 20 q (72.5%), 7 (41.8%), 8 (33.1%) and 13 (51.0%) losses 18 (58.6%), 4 (26%) 21 (21.6%). MSS have significantly more CNAs than microsatellite-instable (MSI) tumors: within MSI novel deletion tumor suppressor WWOX at 16...
Microalbuminuria provides the earliest clinical marker of diabetic nephropathy among patients with Type 1 diabetes, yet it lacks sensitivity and specificity for early histological manifestations disease. In recent years microRNAs have emerged as potential mediators in pathogenesis diabetes complications, suggesting a possible role diagnosis stage We used quantiative polymerase chain reaction (qPCR) to evaluate expression profile 723 unique normoalbuminuric urine who did not develop (n = 10)...
Background/Aims: In this study, a subpopulation of stem-like cells in human high grade serous ovarian carcinomas (ovarian cancer stem cells; OCSCs) were isolated and characterized. Methods: Primary high-grade carcinoma (HGSC) fresh biopsies cultured under serum-free conditions to produce floating spheres. Sphere formation assay, including self-renewal, differentiation potential, chemo-resistance, tumorigenicity determined vitro or vivo. Results: OCSCs overexpressed cell genes (Oct-4, Nanog,...
Circular RNAs (circRNAs) are implicated in a variety of cancers. However, the roles circRNAs gastric cancer (GC) remain largely unknown. In current study, expression profiles were screened GC, using 5 pairs GC and matched non-GC tissues with circRNA chip. Preliminary results verified quantitative PCR (qRT-PCR). Briefly, total 713 differentially expressed vs. (fold change ≥ 2.0, p < 0.05): 191 upregulated, whereas 522 downregulated tissues. qRT-PCR analysis randomly selected 7 from 50 paired...