A5002187013- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Advanced Breast Cancer Therapies
- Gene expression and cancer classification
- Lymphoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Molecular Biology Techniques and Applications
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Statistical Methods in Clinical Trials
- Monoclonal and Polyclonal Antibodies Research
- AI in cancer detection
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Cell Image Analysis Techniques
Pfizer (United States)
2016-2025
PRX Research
2025
Statistical Research (United States)
2024
Nankai University
2024
Harbin Medical University
2023
Third Affiliated Hospital of Harbin Medical University
2023
Yangtze University
2020-2022
First People's Hospital of Jingzhou
2020
Sichuan University
2018-2019
Pfizer (United Kingdom)
2018
Characteristic patterns of gene expression measured by DNA microarrays have been used to classify tumors into clinically relevant subgroups. In this study, we refined the previously defined subtypes breast that could be distinguished their distinct expression. A total 115 malignant were analyzed hierarchical clustering based on 534 "intrinsic" genes and shown subdivide one basal-like, ERBB2-overexpressing, two luminal-like, normal tissue-like subgroup. The for classification selected similar...
Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet molecular basis hepatocarcinogenesis remains largely unknown. Here we report findings from a whole-genome sequencing (WGS) study 88 matched HCC tumor/normal pairs, 81 which are Hepatitis B virus (HBV) positive, seeking to identify genetically altered genes pathways implicated in HBV-associated HCC. We find beta-catenin be frequently mutated oncogene (15.9%) TP53 tumor suppressor...
Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are small noncoding RNA sequences critical to neurodevelopment adult neuronal processes coordinating the activity of multiple genes within biological networks. We examined expression 854 miRNAs in prefrontal cortical tissue from 100 control, schizophrenic, bipolar subjects. The cyclic AMP-responsive element binding-...
Abstract Breast cancer (BC) in the Asia Pacific regions is enriched younger patients and rapidly rising incidence yet its molecular bases remain poorly characterized. Here we analyze whole exomes transcriptomes of 187 primary tumors from a Korean BC cohort (SMC) pre-menopausal perform systematic comparison with primarily Caucasian post-menopausal (TCGA). SMC harbors higher proportions HER2+ Luminal B subtypes, lower proportion A decreased ESR1 expression compared to TCGA. We also observe...
Abstract To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole transcriptome profiling coupled with histopathology analyses a longitudinal breast cancer cohort 146 patients including 110 pairs serial tumor biopsies collected before treatment, after first cycle treatment and at time surgery. Here, show that cytotoxic chemotherapies induce dynamic changes in immune microenvironment vary by subtype pathologic response. Just one induces an stimulatory harboring more...
Cancer is a genetic disease with frequent somatic DNA alterations. Studying recurrent copy number aberrations (CNAs) in human cancers would enable the elucidation of mechanisms and prioritization candidate oncogenic drivers causal roles oncogenesis. We have comprehensively systematically characterized CNAs accompanying gene expression changes tumors matched nontumor liver tissues from 286 hepatocellular carcinoma (HCC) patients. Our analysis identified 29 recurrently amplified 22 deleted...
T cell-invigorating cancer immunotherapies have near-curative potential. However, their clinical benefit is currently limited, as only a fraction of patients respond, suggesting that these regimens may from combination with tumor-targeting treatments. As oncogenic progression accompanied by alterations in metabolic pathways, tumors often become heavily reliant on antioxidant machinery and be susceptible to increases oxidative stress. The cystine-glutamate antiporter xCT frequently...
Abstract Background Cyclin-dependent kinase 4/6 inhibitor (CDK4/6) therapy plus endocrine (ET) is an effective treatment for patients with hormone receptor-positive/human epidermal receptor 2-negative metastatic breast cancer (HR+/HER2− MBC); however, resistance common and poorly understood. A comprehensive genomic transcriptomic analysis of pretreatment post-treatment tumors from receiving palbociclib ET was performed to delineate molecular mechanisms drug resistance. Methods Tissue...
Abstract: Previous studies on the influence of a rural/urban setting prevalence cardiovascular disease risk factors in children have not sufficiently controlled for socioeconomic status, race, gender, and perhaps, may included representative sample rural urban children. This study compared rate obesity living settings. It also determined magnitude effect when controlling gender. The subjects were 2,113 third‐ fourth‐grade children; 962 from an 1,151 setting. Height, weight, skinfolds,...
Immunohistochemistry (IHC) assays play a central role in evaluating biomarker expression tissue sections for diagnostic and research applications. Manual scoring of IHC images, which is the current standard practice, known to have several shortcomings terms reproducibility scalability large scale studies. Here, by using digital image analysis-based approach, we introduce new metric called pixelwise H-score (pix H-score) that quantifies from whole-slide scanned images. The pix an unsupervised...
Recent regulatory guidance suggests that metabolites identified in human plasma should be present at equal or greater levels one of the animal species used safety assessments. In this report, a high-performance liquid chromatography-tandem mass spectrometry method is described whereby quantitative comparisons exposures to between can obtained absence authentic standards metabolites, calibration curves, and other attributes standard bioanalytical methods. This novel was tested using six...
The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens. However, it features a low specificity and provides only limited mechanistic information required risk assessment positive findings. This especially important in case findings the vitro chromosome damage assays, because may be also induced secondarily to cell death. An increasing body evidence indicates that toxicogenomic analysis cellular stress responses an insight into mechanisms action...
In this phase I study (NCT01307267), we evaluated safety, pharmacokinetics, clinical activity, and pharmacodynamics of treatment with utomilumab plus rituximab in patients relapsed/refractory follicular lymphoma (FL) other CD20+ non-Hodgkin lymphomas (NHL).Primary objectives were to assess safety tolerability for estimating the MTD, using a modified time-to-event continual reassessment method, selecting recommended II dose (RP2D).Sixty-seven received (0.03-10.0 mg/kg every 4 weeks) (375...
Abstract Objectives The mechanisms underlying the effects of Toll‐like receptor 9 (TLR9) and autophagy on rheumatoid arthritis (RA)‐aggravated periodontitis are unclear. We aimed to explore a novel target, cathepsin K (Ctsk)‐mediated TLR9‐related autophagy, during progress with RA. Materials Methods DBA/J1 mouse model RA was created by local colonization Porphyromonas gingivalis ( Pg ) injection collagen. expression Ctsk inhibited adeno‐associated virus (AAV). Micro‐CT, immunohistochemistry...
Current methods to quantify T-cell clonal expansion only account for variance due random sampling from a highly diverse repertoire space. We propose beta-binomial model incorporate time-dependent into the assessment of differentially abundant clones, identified by unique T Cell Receptor (TCR) β-chain rearrangements, and show that this improves specificity detecting clinically relevant expansion. Using blood samples ten healthy donors, we modeled clones within each subject over time...