A5113781640- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer, Hypoxia, and Metabolism
- Interactive and Immersive Displays
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Stress Responses and Cortisol
- RNA Research and Splicing
- Tryptophan and brain disorders
- Evolution and Genetic Dynamics
- Genetic factors in colorectal cancer
- Genomics and Rare Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Virtual Reality Applications and Impacts
- Tactile and Sensory Interactions
- Cancer Research and Treatments
- Peroxisome Proliferator-Activated Receptors
Hunan Normal University
2016-2024
Huazhong University of Science and Technology
2015-2023
University of North Carolina at Chapel Hill
2005-2023
Nanjing Medical University
2014-2023
Fujian Medical University
2022-2023
Weatherford College
2023
University of South China
2023
Hangzhou Dianzi University
2015-2022
Wuxi People's Hospital
2022
First Affiliated Hospital of Bengbu Medical College
2022
H19 RNA has been characterized as an oncogenic long non-coding (lncRNA) in breast and colon cancer. However, the role function of lncRNA glioma development remain unclear. In this study, we identified that H19/miR-675 signaling was critical for progression. By analyzing gene expression data sets, found increased high grade gliomas. depletion via siRNA inhibited invasion cells. Further, positively correlated with its derivate miR-675 reduction expression. Bioinformatics luciferase reporter...
Background Cancer-associated fibroblasts (CAFs) are involved in tumor growth, angiogenesis, metastasis, and resistance to therapy. We sought explore the CAFs characteristics hepatocellular carcinoma (HCC) establish a CAF-based risk signature for predicting prognosis of HCC patients. Methods The signal-cell RNA sequencing (scRNA-seq) data was obtained from GEO database. Bulk RNA-seq microarray were TCGA databases respectively. Seurat R package applied process scRNA-seq identify CAF clusters...
Alcohol use disorder (AUD) has been associated with attentional deficits and impairments of working memory. Meanwhile, attention memory are critical for time perception. However, it remains unclear how perception alters in AUD patients affect their The current study aims to clarify the characteristics cognitive mechanisms underlying dysfunction. Thirty-one (three them were excluded) thirty-one matched controls completed Time Bisection Task, Attention Network Test Digital Span Backward assess...
// Wenkang Luan 1,* , Yingyi Wang Xincheng Chen Yan Shi Jiajia 1 Junxia Zhang Jin Qian 2 Ri Li Tao Wenjin Wei Qi Hu Ning Liu and Yongping You Department of Neurosurgery, The First Affiliated Hospital Nanjing Medical University, Nanjing, China People’s Xuancheng City, Anhui, * These authors contributed equally to this work Correspondence to: You, email: Keywords : let-7a microRNA, c-Myc, hnRNPA1, PKM2, glucose metabolism, aerobic glycolysis, glioma Received October 08, 2014 Accepted...
// Wenkang Luan 1, * , Lubo Li 2, Yan Shi 4, Xuefeng Bu 3 Yun Xia 1 Jinlong Wang Henry Siaw Djangmah Xiaohui Liu Yongping You 5 Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, Jiangsu, China 2 Neurosurgery, General 4 Nanjing First Hospital, Medical Nanjing, The These authors have contributed equally to this work Correspondence to: Luan, email: luanwenkang@126.com Xu, xubinfen@126.com Keywords: MALAT1, miR-22, MMP14 and Snail, ceRNA, melanoma...
LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to play prominent roles in tumorigenesis. However, its precise molecular mechanism glioma not completely elucidated. In this study, we found that HOTAIR was aberrantly up-regulated tissues and negatively correlated with miR-126-5p expression. Next, determined promote progression by sponging miR-126-5p. Subsequently, glutaminase (GLS) confirmed be a direct target of using bioinformatics software luciferase reporter assay....
Abstract Long non-coding RNAs (lncRNAs) play a vital role in tumourigenesis, including that of glioma. Small nucleolar RNA host gene 1 (SNHG1) is relatively novel lncRNA involved the development multiple human tumours. However, its underlying molecular mechanism glioma has not been completely clarified. In this study, we show SNHG1 overexpressed tissues and cell lines. A series functional assays suggested promotes progression vitro vivo. Next, through online databases, luciferase reporter...
Abstract Aberrant expression of neuropilin and tolloid-like 2 (NETO2) has been observed during the progression some human carcinomas. However, pattern clinical relevance NETO2 in gastric cancer (GC) remain to be elucidated. In this study, we found that was higher GC tissues compared with paired non-cancerous tissues. Moreover, positively correlated stage, invasion depth, lymph node metastasis, tumor size, but inversely overall disease-free survival rates. Cox regression analysis identified...
// Wenkang Luan 1, * , Rubo Li 2, Liang Liu 3, Xin Ni 4, Yan Shi 3 Yun Xia 1 Jinlong Wang Feng Lu and Bin Xu Department of Plastic Surgery, Affiliated People's Hospital Jiangsu University, Zhenjiang, China 2 Neurosurgery, Nanjing First Hospital, Medical Nanjing, 4 Gastroenterology, These authors have contributed equally to this work Correspondence to: Luan, email: luanwenkang@126.com Xu, xubinfen@126.com Keywords: malignant melanoma, ceRNA, HOTAIR, miR-152-3p, c-MET Received: April 15,...
Hyperhomocysteinemia is an independent risk factor for dementia, including Alzheimer's disease. Lowering homocysteine levels with folic acid treatment or without vitamin B12 has shown few clinical benefits on cognition. To verify the effect of emodin, a naturally active compound from Rheum officinale, hyperhomocysteinemia-induced rats were treated injection (HCY, 400 μg/kg/d, 2 weeks) via vena caudalis. Afterwards, HCY cognitive deficits administered intragastric emodin at different...
Glioblastoma multiforme (GBM) is the most malignant type of glioma. Integrated classification based on mRNA expression microarrays and whole–genome methylation subdivides GBM into five subtypes: Classical, Mesenchymal, Neural, Proneural-CpG island methylator phenotype (G-CIMP) Proneural-non G-CIMP. Biomarkers that can be used to predict prognosis in each subtype have not been systematically investigated. In present study, we Cox regression risk-score analysis construct respective prognostic...
Glioblastoma is an extraordinarily aggressive disease that requires more effective therapeutic options. Snail family zinc finger 1, dysregulated in many neoplasms, has been reported to be involved gliomas. However, the biological mechanisms underlying SNAI1 function gliomas need further investigation.Quantitative real-time PCR was used measure microRNA-128 (miR-128) expression level and western blot performed detect protein U87 U251 cells human brain tissues. Cell cycle, CCK-8, transwell...
Numerous studies have reported that long noncoding RNA (lncRNA) dysregulation is involved in the progression of many malignant tumors, including glioma. The lncRNA ZNFX1 antisense 1 (ZFAS1) plays an oncogenic role various such as gastric cancer and hepatocellular carcinoma. However, underlying molecular mechanism ZFAS1 glioma has not been fully clarified. In this study, we found expression was upregulated both tissues cell lines. Functional experiments revealed promoted proliferation,...
40 Hz light flicker is a well-known non-invasive treatment that thought to be effective in treating Alzheimer's disease. However, the effects of visual stimulation on neural networks, synaptic plasticity, and learning memory wild-type animals remain unclear.We aimed explore impact place cell, mice.c-Fos+ cell distribution vivo electrophysiology was used chronic networks neuroplasticity mice. The character c-Fos+ brain changes corticosterone levels blood were investigate state animal. Place...
Endoplasmic reticulum (ER) stress is involved in Alzheimer's disease (AD), but the mechanism not fully understood. Here, we injected tunicamycin (TM), a recognized ER inducer, into brain ventricle of Sprague-Dawley (SD) rats to induce unfolded protein response (UPR), demonstrated by enhanced phosphorylation pancreatic kinase (PERK), inositol-requiring enzyme-1 (IRE-1) and activating transcription factor-6 (ATF-6). We observed that UPR induced spatial memory deficits impairments synaptic...
The hearing handicapped children show a penchant for dancing and dance plays an essential part in education of deaf children. This paper introduces the Music-touch Shoes, pair shoes particularly designed dancers: rhythm tempo music can be communicated perceived through vibrotactile interaction. interface is applied to because feet are among body parts which most directly involved performing rhythm. different sequences, intensity frequency vibrations reflect music. project sought explore way...