A5100615364- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- DNA and Nucleic Acid Chemistry
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Mosquito-borne diseases and control
- Autophagy in Disease and Therapy
- Nitrogen and Sulfur Effects on Brassica
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- Photosynthetic Processes and Mechanisms
- Advanced biosensing and bioanalysis techniques
- Malaria Research and Control
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Complement system in diseases
- Plant Gene Expression Analysis
- Medical Imaging Techniques and Applications
- Chronic Kidney Disease and Diabetes
- Click Chemistry and Applications
- Medicinal Plants and Bioactive Compounds
- Chemical Synthesis and Analysis
- Synthesis of heterocyclic compounds
- Plant Stress Responses and Tolerance
Qinghai University
2010-2025
Army Medical University
2016-2024
Stanford University
2020-2024
Xinqiao Hospital
2021-2024
Hybrid Rapeseed Research Center of Shaanxi Province
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2022-2024
Jiangxi University of Traditional Chinese Medicine
2024
Beijing Normal University
2022-2023
Shenyang Pharmaceutical University
2023
Children's Hospital of Chongqing Medical University
2021-2023
To determine the relationship of gut microbiota and its metabolites with autism spectrum disorder (ASD)-like behaviors preliminarily explore potential molecular mechanisms, fecal from donors ASD typically developing (TD) were transferred into germ-free (GF) mice to obtain ASD-FMT TD-FMT mice, respectively. Behavioral tests conducted on these after 3 weeks. 16S rRNA gene sequencing cecal contents untargeted metabolomic analysis cecum, serum, prefrontal cortex performed. Untargeted...
Triggering receptor expressed on myeloid cells 1 (TREM-1) is a recently discovered molecule that the cell surface of monocytes and neutrophils. Engagement TREM-1 triggers synthesis proinflammatory cytokines in response to microbes, but extent mechanism by which modulates inflammatory poorly defined. In present study, we investigated functional effects blocking Toll-like (TLR)4-mediated signaling pathway macrophages. By transfecting with small hairpin interfering RNA molecules (shRNA),...
Abstract This study aimed to investigate the role of autophagy, ferroptosis, and pyroptosis in antitumour mechanism harmine (Har) its crosstalk ovarian cancer. By transmission electron microscopy, we found that compared with those control group, cytoplasm human cancer cells (SKOV3) treated Har showed increased numbers autophagic vesicles, decreased intracellular mitochondrial volume, bilayer membrane density, cristae. Western blot, immunofluorescence, monodasylcadaverine (MDC) staining all...
Photocaged (photoactivatable) biomolecules are powerful tools for noninvasive control of biochemical activities by light irradiation. DNAzymes (deoxyribozymes) single-stranded oligonucleotides with a broad range enzymatic activities. In this work, to construct photocaged DNAzymes, we developed facile and mild postsynthetic method incorporate an interesting photolabile modification (thioether-enol phosphate, phenol substituted, TEEP–OH) into readily available phosphorothioate DNA. Upon...
Microcalcification is one of the most reliable clinical features malignancy risk breast cancer, and it associated with enhanced tumour aggressiveness poor prognosis. However, its underlying molecular mechanism remains unclear.Clinical data were retrieved to analyse association between calcification bone metastasis in patients cancer. Using multiple human cancer cell lines, osteogenic cocktail model was established vitro demonstrate calcification-exacerbated metastasis. Migration invasion...
Oxygen-rich pyromellitic acidic anions (PMA4-) have been intercalated into MgAl-layered double hydroxides to fabricate the MgAl-PMA-LDH (abbr. PMA-LDH) composite exhibiting excellent adsorption performance toward uranium (U(VI)). Benefiting from large number of functional groups -COO-, PMA-LDH displays an extremely maximum U capacity (qUm) 352 mg g-1 and ultra-fast sorption rate, reaching uptakes ∼97% within 30 min >99% in 1 h at initial concentration (CU0) 113 ppm. Over a very wide pH range...
Vitamin A (VA) plays an essential role in modulating both the gut microbiota and barrier function. Short-chain fatty acids (SCFAs), as metabolites of microbiota, protect physiological intestinal barrier; however, they are compromised when VA is deficient. Thus, there urgent need to understand how which SCFAs modulate colonic epithelial integrity deficiency (VAD). Herein, compared with normal rats (VAN), at beginning pregnancy, we confirmed that desmosome junction was impaired VAD group,...
Methods for RNA functionalization at specific sites are in high demand but remain a challenge, particularly RNAs produced by transcription rather than total synthesis. Recent studies have described acylimidazole reagents that react yields 2′-OH groups stochastically nonbase-paired regions, covering much of the scattered acyl esters. Localized reactions, if possible, could prove useful many applications, providing functional handles and sequences biopolymer. Here, we describe DNA-directed...
Conditional control of CRISPR-Cas9 activity by reactive oxygen species and visible light is achieved using stimuli-responsive guide RNA synthesized a general method based on 2′-<italic>O</italic>-methylribonucleotide phosphorothioate.
The present study investigated the association among host genome, gut microbiome, and S . Pullorum infection in chickens. results suggested that microbial structure is altered Pullorum-infected
Abstract Methods for the site‐selective labeling of long, native RNAs are needed studying mRNA biology and future therapies. Current approaches involve engineering RNA sequences, which may alter folding, or limited to specific sequences bases. Here, we describe a versatile strategy conjugation via novel DNA‐tiling approach. The method, TRAIL, exploits pool “protector” oligodeoxynucleotides hybridize block mRNA, combined with an “inducer” DNA that extrudes reactive loop acylation at...
By establishing osteoporosis (OP) model in rats, the specific regulatory effect of simvastatin on promoting differentiation mesenchymal stem cells (MSCs) into osteoblasts through bone morphogenetic protein 2 (BMP-2)/Smads signaling pathway was investigated.A total 45 Sprague-Dawley rats were selected to establish OP by performing ovariectomy. The divided group (OP group, n=15), 10-7 mmol/L treatment (SIM and normal control (Control n=15). After experimental period, enzyme-linked...