A5035134744- Chemical Synthesis and Reactions
- Organoboron and organosilicon chemistry
- Asymmetric Hydrogenation and Catalysis
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- DNA and Nucleic Acid Chemistry
- Advancements in Photolithography Techniques
- Biochemical and Molecular Research
- Catalytic Cross-Coupling Reactions
- Synthetic Organic Chemistry Methods
- Synthesis of Indole Derivatives
- Advanced Surface Polishing Techniques
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Muscle Physiology and Disorders
- Oxidative Organic Chemistry Reactions
- Advanced biosensing and bioanalysis techniques
- Asymmetric Synthesis and Catalysis
- Silicone and Siloxane Chemistry
- Vanadium and Halogenation Chemistry
- Synthesis and properties of polymers
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Nanofabrication and Lithography Techniques
Stanford University
2019-2024
Daiichi-Sankyo (Japan)
2017-2023
Osaka University
1998-2016
Kobe University
2010
Osaka Hospital
2009
Toshiba (Japan)
1982-2002
Toshiba (United States)
1991
Mitsubishi Group (Japan)
1988
The direct reduction of alcohols using chlorodiphenylsilane as a hydride source in the presence catalytic amount indium trichloride is described. Benzylic alcohols, secondary and tertiary were effectively reduced to give corresponding alkanes high yields. A compound bearing both primary hydroxyl groups was only at site afford alcohol after workup with Bu(4)NF. This system showed chemoselectivity for group while not reducing other functional that are readily by standard systems. Thus ester,...
Abstract Currently, there are no treatments for Alport syndrome, which is the second most commonly inherited kidney disease. Here we report development of an exon-skipping therapy using antisense-oligonucleotide (ASO) severe male X-linked syndrome (XLAS). We targeted truncating variants in exon 21 COL4A5 gene and conducted a type IV collagen α3/α4/α5 chain triple helix formation assay, vitro vivo treatment efficacy evaluation. show that skipping enabled trimer formation, leading to...
Abstract Incorporating stimuli‐responsive components into RNA constructs provides precise spatiotemporal control over structures and functions. Despite considerable advancements, the utilization of redox‐responsive stimuli for activation caged RNAs remains scarce. In this context, we present a novel strategy that leverages post‐synthetic acylation coupled with chemistry to exert RNA. To achieve this, design synthesize series acylating reagents specifically tailored introducing...
The InCl3-catalyzed reaction of alcohols with chlorodimethylsilane (HSiMe2Cl) in the presence benzil gave corresponding organic chlorides under mild conditions. Benzil significantly changes course because reducing product through dehydroxyhydration was obtained absence benzil. secondary or tertiary were effectively chlorinated. substrates bearing acid-sensitive functional groups also applied to this system. highly selective chlorination site observed competitive between and primary alcohols....
The indium(III) chloride/chlorotrimethylsilane system acts as a catalyst for the Sakurai−Hosomi reaction between allylsilanes and aldehydes. When γ-substituted such crotylsilane prenylsilane are used high regioselectivity γ-addition is observed. Smaller amounts of (5 mol %) effectively afforded allylation products, although larger (20 gave no product whatsoever. Other group 13 Lewis acids AlCl3 BF3·OEt2 did not have catalytic activity even when combined with chlorotrimethylsilane. (©...
The reaction of carbonyls and chlorodimethylsilane was effectively catalyzed by indium(III) hydroxide afforded the corresponding deoxygenative chlorination products, in which carbonyl carbon accepted two nucleophiles (H Cl) with releasing oxygen. Only In(OH)3 reaction, typical Lewis acids such as TiCl4, AlCl3, BF3.OEt2 showed no catalytic activity. mechanism this includes initial hydrosilylation followed chlorination. Other allyl or iodine were available for methodology. moderate acidity...
Background: Dystrophin Dp71 is one of the isoforms produced by DMD gene which mutated in patients with Duchenne muscular dystrophy (DMD). Although expressed ubiquitously, it has not been detected normal skeletal muscle. This study was performed to assess expression human Methods: Human muscle RNA and tissues were obtained commercially. Mouse from DMDmdx mice. mRNA protein determined reverse-transcription PCR an automated capillary Western assay system, Simple Western, respectively....
Acylation of RNA at 2'-OH groups is widely applied in mapping structure and recently for controlling function. Reactions are described that install the smallest 2-carbon acyl on RNA-namely, 2'-O-acetyl 2'-O-carbonate groups. Hybridization thermal melting experiments performed to assess effects duplex formation. Both reagents can be employed lower concentrations map secondary by reverse transcriptase primer extension (SHAPE) methods.
Abstract An In(III)/Si catalyst system effects the direct allyl substitution of alcohols and silyl ethers under mild conditions. A deoxygenation is also promoted by InCl 3 catalyst. This method requires no pretreatment or protection hydroxy groups deprotection siloxy groups. The completion catalytic allylation depends on low oxophilicity high halophilicity In(III) halide species, other representative Lewis acids such as AlCl BF have activity for allylations. are demonstrated NMR studies.
Impaired DNA repair activity has been shown to greatly increase rates of cancer clinically. It hypothesized that upregulating in susceptible individuals may be a useful strategy for inhibiting tumorigenesis. Here, we report selected tyrosine kinase (TK) inhibitors including nilotinib, employed clinically the treatment chronic myeloid leukemia, are activators enzyme Human MutT Homolog 1 (MTH1). MTH1 cleanses oxidatively damaged cellular nucleotide pool by hydrolyzing oxidized...
Abstract The catalytic activity of an aluminum complex/silanol system was found to vary with the ligand as follows: β‐diketonate < β‐ketoester anion ortho‐carbonylphenolate. Aluminum complexes electron donating groups conjugated a carbonyl group had higher activity. catalyst correlated strength interaction between complex and silanol; there were two such mechanisms. Cyclohexene oxide polymerized cationically by activated proton SiOH. is considered be similar Brönsted acid on...
Abstract Investigations into the human 8-oxodGTPase, MutT Homolog 1 (MTH1), have risen sharply since first-in-class MTH1 inhibitors were reported to be highly tumoricidal. However, as a cancer therapeutic target is currently controversial because subsequently developed did not exhibit similar cytotoxic effects. Here, we provide first direct evidence for MTH1-independent 8-oxodGTPase function in cells and tumors, using novel ATP-releasing guanine-oxidized (ARGO) chemical probe. Our studies...
Thrombocytopenic patients with chronic hepatitis C virus (HCV) infection are poor candidates for antiviral treatment interferon (IFN), but no standard thrombocytopenia has yet been established. We evaluated the safety of splenectomy and its efficacy initiation continuation therapy. From March 2003 to April 2006, 10 (mean age 62.5 years) HCV-related cirrhosis, low platelet count (<==106 000/mm(3)) splenomegaly (spleen size >==10 cm) underwent splenectomy. Platelet counts significantly...
Glycogen storage disease type 1a (GSD1a) is caused by a congenital deficiency of glucose-6-phosphatase-alpha (G6Pase-α, encoded G6PC), primarily associated with life-threatening hypoglycemia. Although strict dietary management substantially improves the life expectancy, patients still suffer from intermittent hypoglycemia and develop hepatic complications. Emerging therapies utilizing new modalities such as adeno-associated virus mRNA lipid nanoparticles are under development for GSD1a, but...
Fundamental aspects for a novel LSI pattern fabrication process employing polysilanes as an antireflective layer (ARL) are discussed. The multilayer is composed of organic resist, polysilane layer, and substrate. avoids reflections from the substrate when resist exposed to 248-nm light emitted KrF excimer laser. It also acts transfer layer. etched faster than etching carried out with reactive ions by Cl2 gas. Therefore, transferred precisely. relationship between structure its physical...