A5077922306- Nanowire Synthesis and Applications
- DNA Repair Mechanisms
- CAR-T cell therapy research
- Inflammatory mediators and NSAID effects
- TGF-β signaling in diseases
- Chromosomal and Genetic Variations
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Telomeres, Telomerase, and Senescence
- interferon and immune responses
- Cell Adhesion Molecules Research
- Virus-based gene therapy research
- Nanofabrication and Lithography Techniques
- Genomics and Chromatin Dynamics
Nanjing Normal University
2023-2025
Center for Excellence in Molecular Cell Science
1995-2010
Chinese Academy of Sciences
1995-2005
Shanghai Institutes for Biological Sciences
2005
Chimeric antigen receptor T cell (CAR-T) therapy has shown success in treating hematological malignancies, but its effectiveness against solid tumors is hindered by exhaustion. During vitro expansion, tonic signaling induced CAR expression contributes to CAR-T exhaustion, which can be mitigated inhibiting calcium signaling. Given that sodium citrate chelate ions and inhibit signaling, this study, we investigated whether could reduce exhaustion enhance function. We constructed anti-CD70 cells...
In eukaryotes, chromosomal processes are usually modulated through chromatin-modifying complexes that dynamically targeted to specific regions of chromatin. this study, we show the chromatin-remodeling complex SWR1 (SWR1-C) uses a distinct strategy regulate heterochromatin spreading. Swr1 binds in stable manner near prepare for H2A.Z deposition, which can be triggered by NuA4-mediated acetylation histone H4. We also demonstrate experiments with Swc4, module shared NuA4 and SWR1-C, coupled...
TNF-α-induced protein 8-like 2 (TIPE2 or TNFAIP8L2) is a recently discovered negative regulator of innate and adaptive immunity. TIPE2 expressed in wide range tissues, both immune nonimmune, implicated the maintenance homeostasis within system. Furthermore, has been shown to play pivotal role regulation inflammation development tumor. This review focuses on structural characteristics, expression patterns, functional roles TIPE proteins, with particular emphasis underlying mechanisms its...
Telomerase is a cellular reverse transcriptase that elongates the single-stranded chromosome ends and oligonucleotides in vivo vitro. In Saccharomyces cerevisiae, Est2p (telomerase catalytic subunit) Tlc1 RNA template constitute telomerase core complex. We co-overexpressed GST (glutathione S-transferase)–Est2p S. reconstituted activity. The GST–Est2p–Tlc1 complex was partially purified by ammonium sulphate fractionation affinity chromatography on glutathione beads, did not contain other two...