A5101873114- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- RNA Research and Splicing
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- PARP inhibition in cancer therapy
- DNA and Nucleic Acid Chemistry
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Molecular Biology Techniques and Applications
- Nanowire Synthesis and Applications
- HVDC Systems and Fault Protection
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
- Glutathione Transferases and Polymorphisms
- Prostate Cancer Treatment and Research
- Glycosylation and Glycoproteins Research
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
Nanjing Normal University
2016-2025
China Agricultural University
2023-2025
Southwest Forestry University
2025
Children's Hospital of Fudan University
2021
University Hospital Heidelberg
2019
Heidelberg University
2019
Changzhou No.2 People's Hospital
2018
Harvard University
2017
Beth Israel Deaconess Medical Center
2013
Zhejiang Sci-Tech University
2009
Fusion of the androgen receptor-regulated (AR-regulated) TMPRSS2 gene with ERG in prostate cancer (PCa) causes androgen-stimulated overexpression ERG, an ETS transcription factor, but critical downstream effectors ERG-mediating PCa development remain to be established. Expression SOX9 factor correlated TMPRSS2:ERG fusion 3 independent cohorts, and ERG-dependent expression was confirmed by RNAi fusion-positive VCaP cell line. has been shown mediate ductal morphogenesis fetal maintain...
Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 highly expressed and associated with poor patient prognosis. The suppression could lead to accumulation unrepaired DNA damage cells. Therefore, viewed as an important marker malignant tumors serve potent target development antitumor drugs. this study, we performed...
The transcription factor SOX9 is critical for prostate development, and dysregulation of implicated in cancer (PCa). However, the SOX9-dependent genes pathways involved both normal neoplastic epithelium are largely unknown. Here, we performed ChIP sequencing analysis transcriptome profiling PCa cells determined that positively regulates multiple WNT pathway genes, including those encoding receptors (frizzled [FZD] lipoprotein receptor-related protein [LRP] family members) downstream...
Lung cancer is one of the leading causes mortality worldwide. The therapeutic effect chemotherapy limited due to resistance cells, which remains a challenge in therapeutics. In this work, we found that flap endonuclease 1 (FEN1) overexpressed lung cells. FEN1 major component base excision repair pathway for DNA systems and plays important roles maintaining genomic stability through replication repair. We showed critical rapid proliferation Suppression resulted decreased accumulation damage,...
DNA flap endonuclease 1 (FEN1) plays critical roles in maintaining genome stability and integrity by participating both replication repair. Suppression of FEN1 cells leads to the retardation accumulation unrepaired intermediates, resulting double strand breaks (DSBs) apoptosis. Therefore, targeting could serve as a potent strategy for cancer therapy. In this study, we demonstrated that is overexpressed breast cancers essential rapid proliferation cells. We showed manipulating levels alters...
Abstract Colorectal cancer (CRC) is one of the leading causes cancer-related death worldwide. 5-Fluorouracil (5-FU) widely used in treatment cancers, but its antineoplastic activity limited drug-resistant cells. To investigate detailed mechanism 5-FU resistance, we developed a model 5-FU-resistant cells from HCT-8 cells, well-established colorectal cell line. We found that demonstrated high expression TCF4 and β-catenin, indicating an upregulated Wnt pathway. A microarray analysis revealed...
Methyltransferase-like 3 (METTL3) and N 6 -methyladenosine (m A) are involved in many types of biological pathological processes, including DNA repair. However, the function mechanism METTL3 repair chemotherapeutic response remain largely unknown. In present study, we identified that participates regulation homologous recombination (HR), which further influences both MCF-7 MDA-MB-231 breast cancer (BC) cells. Knockdown sensitized these BC cells to Adriamycin (ADR; also named as doxorubicin)...
It has been demonstrated that interleukin 24 (IL-24, also called melanoma differentiation associated gene 7) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated transfer of IL-24 could induce strong A tumor-selective replicating adenovirus expressing (ZD55-IL-24) was constructed by insertion an expression cassette into the ZD55 vector, which is based on deletion adenoviral E1B 55-kDa gene. ZD55-IL-24 express substantially more than Ad-IL-24 because...
Abstract Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, proinflammatory form of cell death, critically important in RA; however, the detailed mechanism underlying pyroptosis induction not yet well understood. Here, we report that DNA polymerase β (Pol β), key enzyme base excision repair, plays pivotal role RA pathogenesis. Our data shows Pol expression significantly decreased peripheral blood mononuclear cells (PBMCs) from active patients...
Abstract Manganese superoxide dismutase (MnSOD) is a latent tumor suppressor gene. To investigate the therapeutic effect of MnSOD and its mechanisms, replication-competent recombinant adenovirus with E1B 55-kDa gene deletion (ZD55) was constructed, human necrosis factor–related apoptosis-inducing ligand (TRAIL) genes were inserted to form ZD55-MnSOD ZD55-TRAIL. exhibited an inhibition in cell growth ∼1,000-fold greater than Ad-MnSOD. ZD55-TRAIL shown induce expression SW620 cells....
Abstract Mutations of the mouse Attractin (Atrn; formerly mahogany) gene were originally recognized because they suppress Agouti pigment type switching. More recently, effects independent have been recognized: mice homozygous for Atrnmg-3J allele are resistant to diet-induced obesity and also develop abnormal myelination vacuolation in central nervous system. To better understand pathophysiology relationship these pleiotropic effects, we further characterized molecular abnormalities...
Flap endonuclease-1 (FEN1) is a multifunctional, structure-specific nuclease that has critical role in maintaining human genome stability. FEN1 mutations have been detected cancer specimens and suggested to cause genomic instability predisposition. However, the exact relationship between deficiency susceptibility remains unclear. In current work, we report novel colorectal cancer-associated mutation, L209P. This mutant protein lacks FEN, exonuclease (EXO) gap endonuclease (GEN) activities of...
Half-sandwich Os-arene complexes exhibit promising anticancer activity, but their photochemistry has hardly been explored. To exploit the photocytotoxicity and of Os-arenes, O,O-chelated [Os(η6-p-cymene)(Curc)Cl] (OsCUR-1, Curc = curcumin) [Os(η6-biphenyl)(Curc)Cl] (OsCUR-2), N,N-chelated [Os(η6-biphenyl)(dpq)I]PF6 (OsDPQ-2, dpq pyrazino[2,3-f][1,10]phenanthroline) [Os(η6-biphenyl)(bpy)I]PF6 (OsBPY-2, bpy 2,2'-bipyridine), have investigated. The curcumin showed remarkable toward a range...
Light serves as an energy source for cell division and expansion during fruit development. Cell significantly influences size is closely linked to endoreduplication, a unique cycle variation characterized by DNA replication without cytokinesis. Paradoxically, under conditions of ample photosynthates, light signaling suppresses expansion. The intricate regulation endoreduplication in response development has remained intriguing question. Here, our study revealed that Tubby-like F-box protein...
One novel C10 polyacetylene rhamnoside, 4,6,8-decatriyne-1-O-α-L-rhamnopyranoside, named xylariside A (1), together with two quinovopyranosides, 4,6,8-decatriyne-1-O-α-D-quinovopyranoside, B (2), and 8E-decaene-4,6-diyne-1-O-α-D-quinovopyranoside, C (3), were obtained from the solid fermentation of Xylaria sp. VDL4, an endophytic fungus isolated Vaccinium dunalianum wight (Ericaceae). Their chemical structures elucidated through a combination spectroscopic techniques. The antifungal...
Chimeric antigen receptor T cell (CAR-T) therapy has shown success in treating hematological malignancies, but its effectiveness against solid tumors is hindered by exhaustion. During vitro expansion, tonic signaling induced CAR expression contributes to CAR-T exhaustion, which can be mitigated inhibiting calcium signaling. Given that sodium citrate chelate ions and inhibit signaling, this study, we investigated whether could reduce exhaustion enhance function. We constructed anti-CD70 cells...