A5101754218- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Acute Ischemic Stroke Management
- Cardiovascular and exercise physiology
- Botulinum Toxin and Related Neurological Disorders
- Heart Rate Variability and Autonomic Control
- RNA modifications and cancer
- Circular RNAs in diseases
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Corneal Surgery and Treatments
- Spinal Cord Injury Research
- Plant tissue culture and regeneration
- Cerebrovascular and Carotid Artery Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Animal Genetics and Reproduction
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- RNA Interference and Gene Delivery
- Cardiac Health and Mental Health
- Cardiac Fibrosis and Remodeling
- Dementia and Cognitive Impairment Research
Jiangsu Province Hospital
2015-2025
Nanjing Medical University
2016-2025
Soochow University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Guang’anmen Hospital
2024-2025
Changshu No.1 People's Hospital
2012-2025
People’s Hospital of Wenshan Prefecture
2025
University of Chinese Academy of Sciences
2025
Xuzhou Medical College
2024
Tianjin University of Traditional Chinese Medicine
2024
Immune functions decline with aging, leading to increased susceptibility various diseases including tumors. Exploring aging-related molecular targets in elderly patients cancer is thus highly sought after. Here we find that an ER transmembrane enzyme, sterol O-acyltransferase 2 (SOAT2), overexpressed regulatory T (Treg) cells from lung squamous cell carcinoma (LSCC), while radiomics analysis of LSCC associates SOAT2 expression reduced immune infiltration and poor prognosis. Mechanically, ex...
To investigate the possible role of microRNAs in resistance to platinum based chemotherapy non-small cell lung cancer (NSCLC), explore their potential and find biomarkers for prediction response platinum.21 miRNAs were deregulated A549/CDDP. Increased miR-21 expression significantly increased A549 platinum, whereas reduced decreased A549/CDDP cell. This finding was further validated tissue samples 58 patients it found that chemotherapy-resistant (n = 58, p 0.000). And associated with shorter...
Growing evidence has demonstrated exercise as an effective way to promote cardiovascular health and protect against diseases However, the underlying mechanisms of beneficial effects have yet be elucidated. Animal studies are widely used investigate key exercise-induced protection. standardized procedures well-established evaluation indicators for animal models needed guide researchers in carrying out effective, high-quality using prevent treat diseases. In our review, we present commonly...
Gastric cancer (GC) is a major global burden, and only HER2-targeted therapies have been approved in first line clinical therapy. CLDN18.2 has regarded as potential therapeutic target for gastrointestinal tumors, trials process. Hence, the precise, efficient, noninvasive detection of expression important effective application this attractive target. A high similarity protein sequence between CLDN18.1 -18.2 made RNA become more suitable expression. In study, molecular beacon (MB) with...
Heart failure is a continuously developing syndrome of cardiac insufficiency caused by diseases, which becomes major disease endangering human health as well one the main causes death in patients with cardiovascular diseases. The occurrence heart related to hemodynamic abnormalities, neuroendocrine hormones, myocardial damage, remodeling
Introduction The clinical study aimed to evaluate the levels of serum kisspeptin, NKB, and GABA in Chinese patients with polycystic ovary syndrome (PCOS) explore their association hormonal profiles, as well relationship between these PCOS controls.
With the recent surge in interest surrounding generative paradigms, recommendation has increasingly attracted attention of researchers community. This paradigm generally consists two stages. In first stage, pretrained semantic embeddings or collaborative ID are quantized to create item codes, aiming capture and preserve rich knowledge within these codes. The second stage involves utilizing discrete codes perform an autoregressive sequence generation task. Existing methods often either...
Cardiovascular disease is a leading cause of death, with ischemic heart being significant contributor. While percutaneous coronary intervention (PCI) effectively reduces mortality in myocardial infarction patients, its efficacy for unstable angina (UA) patients controversial. Complications associated PCI further limit application UA. RIC hypothesized to be an effective co-intervention that PCI-related complications and may potentially enhance the procedure itself. This pragmatic,...
Modulation or depletion of tumor-infiltrating Tregs (Ti-Tregs) is a promising strategy in the field antitumor immunotherapy. However, this approach poses challenges due to diversity within Treg population and lack precision targeting Ti-Tregs. To selectively efficiently eliminate Ti-Tregs while sparing other immune cells, we developed bispecific antibody, FT10-Fab, TNFR2 CCR8, which are highly expressed on Our results showed that FT10-Fab outperformed monotherapies several tumor models by...
ABSTRACT Objective The current classification of intertrochanteric femoral fractures primarily follows the AO/OTA system, which guides treatment but fails to accurately predict preoperative reduction difficulty. Since quality directly impacts fracture healing, internal fixation success, and patient rehabilitation, developing a standard that aids in predicting difficulty holds significant clinical implications for achieving optimal outcomes. purpose this study was develop criteria based on...
Disorders of consciousness (DoC) are characterized by a broad decline in background excitatory synaptic activity and varying levels cerebral network disruption. Repetitive transcranial magnetic stimulation (rTMS), neuromodulatory technique, is anticipated to assist the recovery consciousness. Nonetheless, ongoing debates persist regarding its effectiveness, light inconsistent results recent research. The purpose this study investigate efficacy rTMS promoting patients with DoC probe impact on...