A5050565917- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Plant Gene Expression Analysis
- Immune cells in cancer
- Nanoplatforms for cancer theranostics
- Horticultural and Viticultural Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Bone and Dental Protein Studies
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Plant Molecular Biology Research
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic and Hepatic Oncology Research
- S100 Proteins and Annexins
- Cholesterol and Lipid Metabolism
- Advanced biosensing and bioanalysis techniques
- Plant biochemistry and biosynthesis
- Advanced Biosensing Techniques and Applications
- Circular RNAs in diseases
- Mechanisms of cancer metastasis
Huashan Hospital
2015-2024
Fudan University
2014-2024
Fudan University Shanghai Cancer Center
2024
Henan University of Science and Technology
2022-2024
Shanghai Medical College of Fudan University
2015
The propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated roles NETs metastasis hepatocellular carcinoma (HCC) and further explored underlying mechanism how affect as well therapeutic value.The were isolated from blood human HCC patients used evaluate formation NETs. expression NET markers was detected tumor specimens. A LPS-induced model investigate role on metastasis. RNA-seq performed...
Abstract Lenvatinib is an inhibitor of multiple receptor tyrosine kinases that was recently authorized for first-line treatment hepatocellular carcinoma (HCC). However, the clinical benefits derived from lenvatinib are limited, highlighting urgent need to understand mechanisms resistance. We report here HCC cells develop resistance by activating EGFR and stimulating EGFR–STAT3–ABCB1 axis. accompanied aberrant cholesterol metabolism lipid raft activation. ABCB1 activated in a raft–dependent...
Abstract Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cells interact with each other is still largely unknown. Exosomes released by tumor have been proved to be effective cell-to-cell signal mediators. We explored the functional of exosomes metastasis potential prognostic values for hepatocellular carcinoma (HCC). were extracted from HCC different metastatic potentials. The effects derived highly (HMH) evaluated both vitro vivo. Exosomal...
In hepatocellular carcinoma (HCC), CD133+/CD44+ cells are one subgroup with high stemness and responsible for metastatic relapse resistance to treatment. Our previous studies have demonstrated that osteopontin (OPN) plays critical roles in HCC metastasis. We further investigated the molecular mechanism underlying role of OPN regulating epigenetically explored possible targeting strategy.CD133+/CD44+ sorting from cell lines tissues was used investigate effects knockdown on stemness. iTRAQ...
Background: Neutrophil extracellular traps (NETs) are net like structure formed by neutrophils in response to certain stimulation. It works as inflammatory regulator and metastasis promoter cancer. Mitochondrial-(mt)DNA is a circular, mitochondria derived double strain molecule, which involved NETs formation. Its role induced alteration hepatocellular carcinoma (HCC) remained unexplored. Method: We evaluated the mitochondrial reactive oxygen species (mitoROS) level peripheral from HCC...
The application of VEGF signaling inhibitors have been associated with more invasive or metastatic behavior cancers including hepatocellular carcinoma (HCC). We explored the contribution MET pathway to enhanced HCC invasion and metastasis by inhibition, investigated antitumor effects NZ001, a novel dual inhibitor VEGFR2, in HCC.Immunocompetent orthotopic mice model hepal-6 was established investigate either antibody alone combination selective on tumor aggressiveness. NZ001 were examined...
Cytoplasmic polyadenylation element binding proteins (CPEBs) are RNA-binding that regulate translation by inducing cytoplasmic polyadenylation. CPEB4 has been reported in association with tumor growth, vascularization, and invasion several cancers. To date, the expression of clinical prognosis breast cancer was never before. We aim to investigate its prognostic significance invasive ductal carcinoma.Immunohistochemical staining estrogen receptor, progesterone human epidermal growth factor...
Hepatocellular carcinoma is the fourth most common cause of cancer-related death. However, cross-talk between tumor immune microenvironment and hepatocellular (HCC) remains unclear.We analyzed expression miR-143-3p in exosomes from different HCC cell lines. Differentially expressed genes (DEGs) Tumor-associated macrophages (TAMs) co-cultured with lines were overlapped target genes. We used Oncomine, Kaplan-Meier plotter, The Cancer Genome Atlas (TCGA) databases to assess Myristoylated...
The mechanisms by which tumor-derived factors remodel the microenvironment of target organs to facilitate cancer metastasis, especially organ-specific remains obscure. Our previous studies have demonstrated that SPP1 plays a key role in promoting metastasis hepatocellular carcinoma (HCC). However, functional roles and shaping pre-metastatic niche (PMN) lung-specific are unclear.
Interleukin-6 (IL-6), an important inflammatory cytokine, is a key factor regulating cancer metastasis. Cancer cells can modulate their tumorigenic abilities by sorting specific microRNAs (miRNAs) as exosomes into the tumor microenvironment. The relationship between IL-6 and exosomal miRNAs related to hepatocellular carcinoma (HCC) metastasis remains be elucidated. We examined metastatic ability of HCC after treatment found that miR-133a-3p was sorted stimulation subsequently released In...
The value of existing prognostic models for intrahepatic cholangiocarcinoma is limited. inclusion gene mutations would enhance the predictive efficacy.In screening cohorts, univariable Cox regression analysis was applied to investigate effect individual mutant genes on overall survival (OS). In training set, multivariable performed evaluate independent roles clinicopathological and mutational parameters, a model constructed. Internal external validations were conducted performance this...
e16248 Background: Only 20% of biliary tract cancer (BTC) patients are eligible for surgical resection with curative intent, 5-year overall survival less than 10% all patients. This rate is even lower in high-risk features. Capecitabine as an adjuvant therapy has been verified to improve survival, however, the efficacy still remains limited. PD-1/L1 antibody combined chemotherapy have demonstrated advanced cancer. study aimed evaluate and safety tislelizumab capecitabine following surgery...
Sterol side-chain reductase 2 (SSR2) is a key enzyme in the synthesis of plant cholesterol pathway. Despite importance watermelon as horticultural cash crop, SSR2 gene has not been previously studied or reported. In this study, 28 genes were identified genome. The physicochemical properties ClaSSR proteins predicted by bioinformatics methods, and structure, conserved motif, chromosome localization, phylogenetic analysis, cis-acting elements, expression patterns, promoter activity analysis...