A5043421617- RNA modifications and cancer
- Skin and Cellular Biology Research
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Cholesterol and Lipid Metabolism
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PARP inhibition in cancer therapy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Wnt/β-catenin signaling in development and cancer
- Cell death mechanisms and regulation
- Fibroblast Growth Factor Research
- Dermatological and Skeletal Disorders
- Immunotherapy and Immune Responses
- Economic and Financial Impacts of Cancer
- Plant Reproductive Biology
Zhongda Hospital Southeast University
2025
Chinese Academy of Sciences
2025
Sichuan Academy of Agricultural Sciences
2025
Chengdu Institute of Biology
2025
Huashan Hospital
2018-2023
Fudan University
2015-2023
Guangzhou Medical University
2021
Peking University First Hospital
2016-2017
Peking University
2009-2017
The First Affiliated Hospital, Sun Yat-sen University
2015
The propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated roles NETs metastasis hepatocellular carcinoma (HCC) and further explored underlying mechanism how affect as well therapeutic value.The were isolated from blood human HCC patients used evaluate formation NETs. expression NET markers was detected tumor specimens. A LPS-induced model investigate role on metastasis. RNA-seq performed...
Background and Aims Recently, clinical trials of lenvatinib plus pembrolizumab in HCC have displayed an impressive objective response rate. This study aimed to clarify the mechanism for optimal patient selection. Approach Results First, patients with HCC, lenvatinib‐treated recurrent tumors had lower programmed death ligand 1 (PD‐L1) expression regulatory T cell (Treg) infiltration compared matched primary tumors. Consistently, C57BL/6 wild‐type mice receiving anti–programmed (PD‐1) therapy,...
The immunosuppressive microenvironment plays an important role in tumor progression and immunotherapy responses. Golgi membrane protein 1 (GOLM1) is correlated to hepatocellular carcinoma (HCC) metastasis. However, little known about the of GOLM1 regulating environment its impact on immunotherapeutic efficacy HCC. In this study, was positively with infiltrating tumor-associated macrophages (TAMs) expressed high levels programmed death-ligand (PD-L1) CD8+ T cell suppression HCC tissues. Both...
Abstract Background Dysregulation of both mitochondrial biogenesis and mitophagy is critical to sustain oncogenic signaling pathways. However, the mechanism in promoting hepatocellular carcinoma (HCC) progression remains poorly understood. In this study, we investigated clinical significance biological involvement inner membrane protein STOML2 HCC. Methods was identified by gene expression profiles HCC tissues measured tissue microarray cell lines. Gain/loss-of-function experiment applied...
Abstract Background Mitochondrial dynamics plays an important role in tumour progression. However, how these integrate metabolism hepatocellular carcinoma (HCC) metastasis is still unclear. Methods The mitochondrial fusion protein mitofusin-1 (MFN1) expression and its prognostic value are detected HCC. effects underlying mechanisms of MFN1 on HCC metabolic reprogramming analysed both vitro vivo. Results dynamics, represented by constant fission fusion, found to be associated with metastasis....
Abstract The caspase family is well characterized as playing a crucial role in modulation of programmed cell death ( PCD ), which genetically regulated, evolutionarily conserved process with numerous links to many human diseases, most notably cancer. In this review, we focus on summarizing the intricate relationships between some members and their key apoptotic mediators, involving tumour necrosis factor receptors, Bcl‐2 family, cytochrome c , Apaf‐1 IAP s cancer initiation progression. We...
Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed investigate how colorectal cancer (CRC) overcome lipid peroxidation sustain metastatic colonization liver.Orthotopic liver metastasis (CRLM) and CRC mouse models were constructed determine roles of AADAC The levels detected or tissues. overexpression LMs its clinical relevance analyzed. oncogenic role was evaluated cell...
Abstract Tumor‐associated macrophages (TAMs) are crucial components of the tumor microenvironment. They play vital roles in hepatocellular carcinoma (HCC) progression. However, interactions between TAMs and HCC cells have not been fully characterized. In this study, were induced using human monocytic cell line THP‐1 vitro to investigate their functions S100 calcium‐binding protein A9 (S100A9), an inflammatory microenvironment‐related secreted protein, was identified be significantly...
Aberrant activation of receptor tyrosine kinases (RTKs) and the subsequent metabolic reprogramming play critical roles in cancer progression. Our previous study has shown that Golgi membrane protein 1 (GOLM1) promotes hepatocellular carcinoma (HCC) metastasis by enhancing recycling RTKs. However, how this RTK process is regulated coupled with degradation remains poorly defined. Here, we demonstrate cholesterol suppresses autophagic RTKs a GOLM1-dependent manner. Further mechanistic studies...
Lenvatinib has become the first-line therapy in advanced hepatocellular carcinoma (HCC), but its efficacy is still limited because of inevitable development resistance. It been reported that cellular cholesterol levels are associated with tyrosine kinase inhibitor (TKI) efficacy. Here, we show betulin, a sterol regulatory element-binding protein 2 (SREBP2) inhibitor, markedly enhances anti-tumor effect lenvatinib HCC both
Non-suicidal self-injury (NSSI) is considered a cathartic approach to reducing negative emotions; repeated occurrences increase the risk of suicide. Applying an information-knowledge-attitude-practice (IKAP) model might help patients establish effective and sustainable ways express emotions cope with difficulties, NSSI. We explored IKAP-based intervention on NSSI among adolescents young adult major depressive disorder (MDD). A total 120 adolescent MDD who reported were recruited from January...
<title>Abstract</title> Thousand-grain weight (TGW), mainly determined by grain length (GL) and width (GW), is an important yield component of wheat. In the study, combined with phenotyping in four field trials a high-quality genetic map constructed Wheat 55K SNP array, total seven stable QTLs for TGW, GW GL were identified doubled haploid (DH) population derived from cross between Chuanmai 42 (CM42) Kechengmai 4 (K4), which <italic>QTgw.CK4-cib-3D</italic>, <italic>QGw.CK4-cib-2D</italic>...
In this study, we explored the gene and microRNA (miRNA) expressions profile of esophageal carcinoma. The expression data for messenger RNAs miRNAs in normal cancerous tissues were obtained from Cancer Genome Atlas database then differentially expressed genes identified. As a result, identified 2962 45 carcinoma compared with tissues. Subsequently, altered functions signaling pathways investigated using ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses, these significantly...
Sorafenib is the first approved systemic therapy for advanced hepatocellular carcinoma (HCC) and first-line choice in clinic. Sustained activation of receptor tyrosine kinases (RTKs) associated with low efficacy sorafenib HCC. Activation liver X (LXR) has been reported to inhibit some RTKs. In this study, we found that LXR agonist enhanced anti-tumor activity a subset HCC cells high LXR-β/α gene expression ratio. Mechanically, suppressed dependent recruitment MET epidermal growth factor...
Autosomal recessive lamellar ichthyosis (LI) is a severe skin disorder characterized by generalized hyperkeratosis. Gene mutation in transglutaminase 1 (TGM1), which mediates cross-links the formation of cell envelope during terminal differentiation epidermis, has been identified as cause LI.To determine mutations TGM1 gene three Chinese families with LI.The was sequenced to identify disease-causing LI. One results confirmed using reverse transcriptase PCR and situ hybridization. An (TGase)...
Histone methyltransferases are important determinants of the initiation and progression hepatocellular carcinoma (HCC) represent promising therapeutic targets. However, whether expression profile multiple histone represents a poorer prognosis is entirely unknown. The aim present study was to investigate association between methylation HCC phenotype, prognostic value combining levels SET domain‑containing protein 8 (SET8) with arginine methyltransferase 5 (PRMT5) in patients following...
Interleukin-6 (IL-6), an important inflammatory cytokine, is a key factor regulating cancer metastasis. Cancer cells can modulate their tumorigenic abilities by sorting specific microRNAs (miRNAs) as exosomes into the tumor microenvironment. The relationship between IL-6 and exosomal miRNAs related to hepatocellular carcinoma (HCC) metastasis remains be elucidated. We examined metastatic ability of HCC after treatment found that miR-133a-3p was sorted stimulation subsequently released In...
Recessive dystrophic epidermolysis bullosa (RDEB) is a rare heritable blistering skin condition caused by loss‐of‐function mutations in the COL7A1 gene. Incongruent gene transmission occasionally reported recessive diseases, and its underlying mechanism often uniparental disomy (UPD). To understand genetic basis of incongruent Chinese family with RDEB, which discrepancy genotyping was encountered during our mutation analysis. We used pCAS2 minigene‐based vitro splicing assay to confirm...