A5001770452- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Hypoxia, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Immune cells in cancer
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Ovarian cancer diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Flavonoids in Medical Research
- Genetic factors in colorectal cancer
- Chromatin Remodeling and Cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Bone and Dental Protein Studies
- S100 Proteins and Annexins
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
Fudan University
2002-2020
Huashan Hospital
2019-2020
Fudan University Shanghai Cancer Center
2012-2019
Capital Medical University
2016-2018
Beijing Chest Hospital
2018
Beijing Shijitan Hospital
2016
Zhongshan Hospital
2002-2012
The First Affiliated Hospital, Sun Yat-sen University
2009-2012
Sun Yat-sen University
2009-2012
Ministry of Education of the People's Republic of China
2011
Abstract Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify with high risk of recurrence, which would warrant additional In this study, we sought analyze a recently developed metastasis-related gene signature for its utility predicting HCC survival, using 2 independent cohorts consisting total 386 received radical resection. Cohort 1 contained 247 predominantly HBV-positive cases...
Hepatocellular carcinoma is a common and aggressive cancer that occurs mainly in men. We examined microRNA expression patterns, survival, response to interferon alfa both men women with the disease.We analyzed three independent cohorts included total of 455 patients hepatocellular who had undergone radical tumor resection between 1999 2003. MicroRNA-expression profiling was performed cohort 241 identify tumor-related microRNAs determine their association survival women. In addition, validate...
MicroRNAs (miRNAs) are endogenous small noncoding RNAs that regulate gene expression with functional links to tumorigenesis. Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and it heterogeneous in clinical outcomes biological activities. Recently, we have identified a subset highly invasive epithelial cell adhesion molecule (EpCAM)+ HCC cells from alpha-fetoprotein (AFP)+ tumors cancer stem/progenitor features, is, abilities self-renew, differentiate, initiate...
In the tumour microenvironment, critical drivers of immune escape include oncogenic activity cell-intrinsic osteopontin (OPN), expression programmed death ligand 1 (PD-L1) and expansion tumour-associated macrophages (TAMs). We investigated feasibility targeting these pathways as a therapeutic option in hepatocellular carcinoma (HCC) mouse models.We analysed number tumour-infiltrating cells inflammatory profiles chemically induced liver isolated from wild-type OPNknockout (KO) mice. vitro...
Abstract Tumor‐associated macrophages (TAMs) are crucial components of the tumor microenvironment. They play vital roles in hepatocellular carcinoma (HCC) progression. However, interactions between TAMs and HCC cells have not been fully characterized. In this study, were induced using human monocytic cell line THP‐1 vitro to investigate their functions S100 calcium‐binding protein A9 (S100A9), an inflammatory microenvironment‐related secreted protein, was identified be significantly...
Few studies have investigated the pathologic types and prognosis of hepatocellular carcinoma (HCC) with lymph node metastasis (LNM). The purpose was to explore pertinent therapy HCC LNM.An immunohistochemical study for CK19 OV-6 performed on tissue microarrays LNM (n=47) those without (n=125). clinicopathologic factors patient survival were analyzed.Immunopositivity in higher than that 125 (27.7% vs 5.6%, P=.000; 29.8% 12.8%, P=.009); their expressions significantly correlated (correlation...
Abstract BACKGROUND: Although the incidence of hepatitis B virus surface antigen (HBsAg)‐negative/hepatitis C antibody (HCVAb)‐negative hepatocellular carcinoma (NBNC‐HCC) is gradually increasing, it has been mostly ignored in previous studies. The objective this exploratory study was to investigate clinicopathologic characteristics and prognostic factors that influence recurrence survival patients with NBNC‐HCC. METHODS: A retrospective analysis performed 675 NBNC‐HCC 3529...
We performed our study to determine whether plasma macrophage migration inhibitory factor (MIF) levels have diagnostic and prognostic value in hepatocellular carcinoma (HCC) patients. Enzyme-linked immunosorbent assay (ELISA) immunohistochemistry were used measure the expression of MIF tissues, respectively. Plasma compared HCC occurrence, clinicopathological features outcomes. Cutpoints for diagnosis prognosis were, respectively, determined by receiver operating characteristic analysis...
Our previous study has identified HTPAP as a novel metastasis suppressor from chromosome 8p which is often deleted in metastatic HCC. We sought to further evaluate the expression levels of transcript variants (HTPAP‐1, HTPAP‐2 and HTPAP‐3) 67 HCC tumor tissues 11 normal liver by RT‐PCR with specific TaqMan probes primer sets, explore their association survival. found that three were quite different HCCs. Only HTPAP‐1 was be significantly associated ( P = 0.00053), overall survival 0.0023)...
Objective: To investigate the efficacy and safety of cryotherapy combined with balloon dilatation through electronic bronchoscope in management airway occlusion caused by scar stenosis type tracheobronchial tuberculosis (TBTB). Methods: From December 2008 to May 2016, 98 cases TBTB were diagnosed microbiology, histopathology, CT (computer tomography), bronchial reconstructions bronchoscopy. All patients underwent routine anti-tuberculosis chemotherapy bronchoscope. The whose airways reopened...
Objective: To evaluate the efficacy and adverse reactions of licartin with repeated administration in treatment hepatocellular carcinoma (HCC) patients after liver transplantation. Methods: Clinical data 60 transplantation Tianjin First Central Hospital from December 2012 to 2016 were collected analyzed.The divided into A group(received single therapy, n=45)and B therapy equal or greater than twice, n=15). The results blood routine examination, function thyroid between two groups(1 week...