A5100459646- Lung Cancer Treatments and Mutations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Leptospirosis research and findings
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Veterinary medicine and infectious diseases
- Drug-Induced Hepatotoxicity and Protection
- Crop Yield and Soil Fertility
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Pharmacogenetics and Drug Metabolism
- Cervical Cancer and HPV Research
- Neonatal Respiratory Health Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Parasites and Host Interactions
- Chromosomal and Genetic Variations
- Parasite Biology and Host Interactions
- MicroRNA in disease regulation
- PI3K/AKT/mTOR signaling in cancer
Shanghai Jiao Tong University
2016-2025
Guangzhou Medical University
2014-2025
First Affiliated Hospital of Guangzhou Medical University
2014-2025
Huazhong Agricultural University
2025
State Key Laboratory of Respiratory Disease
2015-2025
Chinese Academy of Sciences
2022-2025
Guangzhou Institutes of Biomedicine and Health
2022-2025
Hainan Medical University
2020-2025
Dazhou Central Hospital
2025
Hainan General Hospital
2015-2025
Salt stress dramatically impedes plant growth and development as well crop yield. The apple production regions are reduced every year, because of the secondary salt damage by improper fertilization irrigation. To expand cultivation area (Malus domestica) select salt-resistant varieties, mechanism tolerance in is necessary to be clarified. miR156/SPL regulatory module plays key roles embryogenesis, morphogenesis, life cycle stage transformation, flower formation other processes. However, its...
Optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is controversial, especially in the context of potential benefit combining PD-1 blockade with neoadjuvant therapy. This phase 2 study aimed to assess camrelizumab plus chemotherapy this population. Patients (clinical stage II-IVA) received two cycles chemoimmunotherapy (NIC) (200 mg on day 1) nab-paclitaxel (260 mg/m2 total 1 and 8) cisplatin (75 days 1-3) each 21-day cycle. Surgery was performed approximately 6 weeks...
Abstract Epidemiological knowledge of circulating carbapenem-resistant Klebsiella pneumoniae (CRKP) is needed to develop effective strategies against this public health threat. Here we present a longitudinal analysis 1,017 CRKP isolates recovered from patients 40 hospitals across China between 2016 and 2020. Virulence gene capsule typing revealed expansion type KL64 (59.5%) alongside decreases in KL47 prevalence. Hypervirulent increased prevalence 28.2% 45.7% Phylogenetic spatiotemporal...
Carbapenem-resistant Acinetobacter baumannii (CRAB) which is noted as a major pathogen associated with healthcare-associated infections has steadily developed beyond antibiotic control. Lytic bacteriophages the characteristics of infecting and lysing specific bacteria have been used potential alternative to traditional antibiotics solve multidrug-resistant bacterial infections. Here, we isolated A. baumannii-specific lytic phages evaluated their therapeutic effect against lung infection...
The increasing prevalence of infections caused by multidrug-resistant Klebsiella pneumoniae necessitates the development alternative therapies. Here, we isolated, characterized, and sequenced a K. bacteriophage (SH-KP152226) that specifically infects lyses capsular type K47. phage SH-KP152226 contains genome 41,420 bp encodes 48 predicted proteins. Among these proteins, Dep42, gene product ORF42, is putative tail fiber protein hypothetically possesses depolymerase activity. We demonstrated...
Enterohemorrhagic Escherichia coli (EHEC) is one major type of contagious and foodborne pathogens. The VI secretion system (T6SS) has been shown to be involved in the bacterial pathogenicity bacteria-bacteria competition. Here, we show that EHEC could secrete a novel effector KatN, Mn-containing catalase, T6SS-dependent manner. Expression katN promoted by RpoS OxyR repressed H-NS, contributes growth under oxidative stress vitro. KatN secreted into host cell cytosol after phagocytized...
Abstract The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis 335 primary adenocarcinomas 35 corresponding lymph node metastases Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly gene TP53 novel mutation targets such as RHPN2 , GLI3 MRC2 . mutations furthermore enriched tumours harbouring metastases. Genes...
DNA modifications vary in form and function but generally do not alter Watson-Crick base pairing. Diaminopurine (Z) is an exception because it completely replaces adenine forms three hydrogen bonds with thymine cyanophage S-2L genomic DNA. However, the biosynthesis, prevalence, importance of Z genomes remain unexplored. Here, we report a multienzyme system that supports Z-genome synthesis. We identified dozens globally widespread phages harboring such enzymes, further verified genome one...
Alcoholic liver injury leads to serious complication including death. The potential role of baicalin at the transcription level in mice model alcohol is not known yet. In this study, we examined effect against chronic plus binge ethanol and understanding mechanism protection. Liver function, histology, steatosis, inflammation, NF-κB activity, oxidative stress sources, nuclear translocation NRF2 factor, cell death were assessed. Treatment with ameliorated ethanol-induced stress, Baicalin...
Cancer cells are characterized by aberrant activation of lipid biosynthesis, producing saturated fatty acids and monounsaturated via stearoyl-CoA desaturases (SCD) for regulating metabolic signaling platforms. SCD1 overexpression functions as an oncogene in lung cancer predicts a poor clinical outcome. This study aimed to investigate the role inhibition EGFR inhibitor (Gefitinib)-based anti-tumor therapy both vitro vivo. CCK-8 assay was performed determine cell viability. The mRNA level...
Abstract Molecular profiling of lung cancer has become essential for prediction an individual’s response to targeted therapies. Next-generation sequencing (NGS) is a promising technique routine diagnostics, but not been sufficiently evaluated in terms feasibility, reliability, cost and capacity with diagnostic formalin-fixed, paraffin-embedded (FFPE) materials. Here, we report the validation application test based on Ion Proton technology rapid characterisation single nucleotide variations...
Sparsentan is a novel single-molecule dual endothelin angiotensin receptor antagonist with hemodynamic and anti-inflammatory properties not an immunosuppressant. The ongoing phase 3 PROTECT trial examines sparsentan in adults IgA nephropathy (IgAN).The (NCT03762850) multicenter, international, randomized, double-blind, parallel-group, active-controlled study. efficacy safety of versus the active control irbesartan being evaluated biopsy-proven IgAN proteinuria ≥1.0 g/d despite maximized...
Colorectal cancer (CRC) is one of the most common cancers worldwide, with a particularly high incidence in developed countries. Distant metastasis and recurrence are main causes CRC-related deaths. MicroRNAs (miRNAs) serum make them potential biomarkers for cancers, as reported or tumor tissues from CRC patients. In this study, we found that miR-612 expression was significantly lower cells compared peritumor normal cells, metastatic specimens non-metastatic specimens, whereas AKT2 exhibited...
An increased risk of non-small cell lung cancer (NSCLC) in cystic fibrosis (CF) patients and carriers CF transmembrane conductance regulator (CFTR) mutations has been proposed. However, the role CFTR remains controversial. In present study, expression was assessed 165 NSCLC tumors 22 normal samples with validation an independent series 131 samples. The effect gain loss on malignant behavior examined. manipulation tumor metastasis examined a mouse model. Expression downregulated (p=0.041)....