A5100457132- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- Caveolin-1 and cellular processes
- Genetic Mapping and Diversity in Plants and Animals
- Mitochondrial Function and Pathology
- Advanced biosensing and bioanalysis techniques
- Cancer-related gene regulation
- Immune cells in cancer
- ATP Synthase and ATPases Research
- Nanopore and Nanochannel Transport Studies
- Circular RNAs in diseases
- Genomics and Phylogenetic Studies
- Pancreatic function and diabetes
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
State Key Laboratory of Oncogene and Related Genes
2014-2024
Shanghai Cancer Institute
2014-2024
Ministry of Agriculture and Rural Affairs
2020-2024
Shanghai Jiao Tong University
2014-2024
Jiangsu University
2022-2024
Nanjing Agricultural University
2018-2024
Washington University in St. Louis
2018-2024
Ministry of Education of the People's Republic of China
2020-2024
Northwest University
2020-2024
Changhai Hospital
2024
Proliferating cells often have increased glucose consumption and lactate excretion relative to the same in quiescent state, a phenomenon known as Warburg effect. Despite an increase glycolysis, however, here we show that non-transformed mouse fibroblasts also oxidative phosphorylation (OXPHOS) by nearly two-fold mitochondrial coupling efficiency ~30% during proliferation. Both increases are supported fusion. Impairing fusion knocking down mitofusion-2 (Mfn2) was sufficient attenuate...
Lysyl oxidase-like 4 (LOXL4) has been found to be dysregulated in several human malignancies, including hepatocellular carcinoma (HCC). However, the role of LOXL4 HCC progression remains largely unclear. In this study, we investigated clinical significance and biological involvement HCC. expression was measured tissues cell lines. Overexpression, shRNA-mediated knockdown, recombinant (rhLOXL4), deletion mutants were applied study function Exosomes derived from lines assessed for ability...
Monoamine oxidase A (MAOA), a catecholamine neurotransmitter degrading enzyme, is closely associated with neurological and psychiatric disorders. However, its role in cancer progression remains unknown.Hepatocellular carcinoma (HCC) tissue arrays (n=254) were used to investigate the correlation between MAOA expression clinicopathological findings. In vitro invasion anoikis assays, vivo intrahepatic lung metastasis models determine of HCC metastasis. Quantitative real-time PCR, western...
Background and aims Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death worldwide. Neurotransmitter-initiated signalling pathway profoundly implicated in tumour initiation progression. Here, we investigated whether dysregulated neurotransmitter receptors play role during pancreatic tumourigenesis. Methods The Cancer Genome Atlas Gene Expression Omnibus datasets were used to identify differentially expressed receptors. expression pattern gamma-aminobutyric acid...
Tumor-associated macrophages (TAM) represent key regulators of the complex interplay between cancer and immune microenvironment. Matricellular protein SPON2 is essential for recruiting lymphocytes initiating responses. Recent studies have shown that has complicated roles in cell migration tumor progression. Here we report that, microenvironment hepatocellular carcinoma (HCC), not only promotes infiltration M1-like but also inhibits metastasis. SPON2-α4β1 integrin signaling activated RhoA...
Extensive research has reported that the tumor microenvironment components play crucial roles in progression. Thus, blocking supports of is a promising approach to prevent cancer We aimed determine whether extracellular ATP-P2RY2 axis could be potential therapeutic for PDAC treatment.Expression P2RY2 was determined 264 human samples and correlated patient survival. inhibited cell lines by antagonist shRNA, respectively, viability, clonogenicity, glycolysis were determined. RNA sequencing...
High-risk human papillomavirus oncoproteins E6 and E7 are the major etiological factors of cervical cancer but insufficient for malignant transformation cancer. Dysregulated alternative splicing, mainly ascribed to aberrant splicing factor levels activities, contributes most hallmarks. However, do regulate expression factors? Does acts as an "accomplice" E6E7 promote progression? Here, we identified that SRSF10, which promotes tumorigenesis cervix, was upregulated by via E2F1 transcriptional...
Abstract The immunosuppressive microenvironment that is shaped by hepatic metastatic pancreatic ductal adenocarcinoma (PDAC) essential for tumor cell evasion of immune destruction. Neutrophils are important components the and exhibit heterogeneity. However, specific phenotypes, functions regulatory mechanisms neutrophils in PDAC liver metastases remain unknown. Here, we show a subset P2RX1-negative accumulate clinical murine metastases. RNA sequencing metastasis-infiltrated P2RX1-deficient...
Hepatic fibrosis is caused by chronic liver injury and may progress toward cirrhosis, even hepatocellular carcinoma. However, current treatment not satisfactory. Therefore, there a mandate to find novel therapeutic targets improve therapy, biomarkers monitor response.
Cellular metabolic reprogramming is the main characteristic of cancer cells and identification targets using this pattern extremely important to treat cancers, such as osteosarcoma (OS). In study, SLIT2 ROBO1 were upregulated in OS, higher expression was associated with worse overall survival rate. Furthermore, vitro vivo experiments demonstrated that SLIT2/ROBO1 axis promotes proliferation, inhibits apoptosis, contributes Warburg effect OS cells. Mechanistically, exerted cancer-promoting...
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Studies on peroxisome proliferator-activated receptor (PPAR)-γ ligands have been focused agonists. However, PPARγ activation may induce obesity and nonalcoholic fatty liver disease (NAFLD), one of the most challenging medical conditions. Here, we identified that isorhamnetin, a naturally occurring compound in fruits vegetables metabolite quercetin, is novel antagonist PPARγ. Isorhamnetin treatment inhibited adipocyte differentiation induced by agonist rosiglitazone, reduced development...
Purpose: Due to a lack of recognized molecular targets for therapy, patients with triple-negative breast cancer (TNBC), unlike other subtypes cancers, generally have not benefited from the advances made targeted agents. The CXCR4/SDF-1 axis is involved in tumor growth and metastasis TNBC. Therefore, down-regulation expression CXCR4 cells potential therapeutic strategy inhibiting primary In order identify bioactive compounds that inhibit traditional Chinese medicines, we investigated capacity...
Melanoma cell adhesion molecule (MCAM) is a that abnormally expressed in variety of tumours and closely associated with tumour metastasis. The role MCAM ovarian cancer development has not been fully studied. In this study, through immunohistochemical staining tissue samples RNA interference to silence cells, we examined the impact on biological functions cells attempted reveal development. Our results showed expression was particularly high metastatic cancers compared other pathological...
// Yuh-Jin Liang 1 , Chen-Yu Wang 2 I-An Yi-Wen Chen Li-Tzu Li Chuang-Yu Lin Ming-Yi Ho Tsung-Lung Chou Ya-Hui Shih-Pin Chiou Yu-Ju and John Yu 1, 3 Institute of Stem Cell Translational Cancer Research, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan Department Physiology Pharmacology, College Medicine, University, Cellular Organismic Biology, Academia Sinica, Taipei, Correspondence to: Yu, email: johnyu@gate.sinica.edu.tw Liang, yuh.jin.liang@gmail.com Keywords: glycosphingolipid,...
Abstract 3β-Hydroxysteroid-Δ24 reductase (DHCR24), the final enzyme of cholesterol biosynthetic pathway, has been associated with urogenital neoplasms. However, function DHCR24 in endometrial cancer (EC) remains largely elusive. Here, we analyzed expression profile and progesterone receptor (PGR) our tissue microarray EC (n = 258), existing database GEO (Gene Expression Omnibus), TCGA (The Cancer Genome Atlas). We found that was significantly elevated patients EC, up-regulation advanced...