A5115590326- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Renal Diseases and Glomerulopathies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Radiopharmaceutical Chemistry and Applications
- Cerebrovascular and Carotid Artery Diseases
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Musculoskeletal pain and rehabilitation
- Cancer, Stress, Anesthesia, and Immune Response
- Hepatitis B Virus Studies
- Medical Imaging Techniques and Applications
- Renal and related cancers
- Renal cell carcinoma treatment
- Pain Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
Jiangxi University of Technology
2025
Sichuan University
2016-2025
Nanjing University
2015-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2025
Southwest Medical University
2015-2025
Guangxi University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2025
Chongqing Medical University
2016-2025
Yangtze University
2024-2025
Zhejiang University
2007-2025
Tissue stiffening is a hallmark of fibrotic disorders but has traditionally been regarded as an outcome fibrosis, not contributing factor to pathogenesis. In this study, we show that fibrosis induced by bleomycin injury in the murine lung locally increases median tissue stiffness sixfold relative normal parenchyma. Across pathophysiological range, cultured fibroblasts transition from surprisingly quiescent state progressive proliferation and matrix synthesis, accompanied coordinated...
Microtubule-associated protein tau is abnormally hyperphosphorylated and aggregated into neurofibrillary tangles in brains of individuals with Alzheimer's disease (AD) other tauopathies. Tau pathology critical to pathogenesis correlates the severity dementia. However, mechanisms leading abnormal hyperphosphorylation are unknown. Here, we demonstrate that human brain was modified by O-GlcNAcylation, a type O-glycosylation which monosaccharide β- N -acetylglucosamine (GlcNAc) attaches...
Improving the immunomodulatory efficacy of mesenchymal stem cells (MSCs) through pretreatment with pro-inflammatory cytokines is an evolving field investigation. However, underlying mechanisms have not been fully clarified. Here, we pretreated human umbilical cord-derived MSCs interleukin-1β (IL-1β) and evaluated their therapeutic effects in a cecal ligation puncture-induced sepsis model. We found that systemic administration IL-1β-pretreated (βMSCs) ameliorated symptoms murine more...
Chronic sleep deprivation perturbs the circadian clock and increases susceptibility to diseases such as diabetes, obesity, cancer. Increased inflammation is one of common underlying mechanisms these diseases, thus raising a hypothesis that circadian-oscillator components may regulate immune response. Here we show absence core component protein cryptochrome (CRY) leads constitutive elevation proinflammatory cytokines in cell-autonomous manner. We observed NF–κB kinase A (PKA) signaling...
Stimuli-responsive in situ self-assembly of small molecules to form nanostructures living subjects has produced promising tools for molecular imaging and tissue engineering. However, controlling the process simultaneously activate multimodality signals a small-molecule probe is challenging. In this paper, we rationally integrate fluorogenic reaction into enzyme-responsive design small-molecule-based activatable near-infrared (NIR) fluorescence magnetic resonance (MR) bimodal probes imaging....
Potentiating anti-tumor immunity by inducing tumor inflammation and T cell-mediated responses are a promising area of cancer therapy. Immunomodulatory agents that promote these effects function via wide variety mechanisms, including upregulation antigen presentation pathways. Here, we show major histocompatibility class-I (MHC-I) genes methylated in human breast cancers, suppressing their expression. Treatment cell lines with next-generation hypomethylating agent, guadecitabine, upregulates...
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD translocation and pore formation are not fully understood. Here, using a proteomic approach, we identified fatty acid synthase (FASN) as GSDMD-binding partner. S-palmitoylation at Cys
Abstract Macrophages (Mφ) autophagy is a pivotal contributor to inflammation-related diseases. However, the mechanistic details of its direct role in acute kidney injury (AKI) were unclear. Here, we show that Mφ promote AKI progression via crosstalk with tubular epithelial cells (TECs), and was activated then inhibited cisplatin-induced mice. Mφ-specific depletion ATG7 (Atg7 Δmye ) aggravated mice, which associated tubulointerstitial inflammation. Moreover, Mφ-derived exosomes from Atg7 mice...
It has been shown that lipid peroxidation is associated with hepatic fibrosis and stellate cell activation. Sho–saiko–to (TJ–9) an herbal medicine, which commonly used to treat chronic hepatitis in Japan, although the mechanism by TJ–9 protects against not known. As a result, we assayed preventive therapeutic effects of on experimental fibrosis, induced rats dimethylnitrosamine (DMN) or pig serum (PS), rat cells hepatocytes primary culture, assessed antioxidative activities active components...
Objectives: The Computer-Aided System for CArdiovascular Disease Evaluation (CASCADE) has been developed streamlined, automated analysis of carotid artery magnetic resonance imaging to measure atherosclerotic plaque burden and composition in vivo. purpose this investigation was assess the performance CASCADE compared with manual outlining. Methods: Magnetic images were obtained from 26 subjects 16% 79% stenosis by duplex ultrasound who imaged twice a 2-week period multiple-slice,...
Abstract Lead (Pb) is a known nephrotoxicant that causes damage to proximal tubular cells. Autophagy has an important protective role in various renal injuries, but the of autophagy Pb-elicited nephrotoxicity remains largely unknown. In this study, Pb promoted accumulation autophagosomes primary rat (rPT) cells, and subsequent findings revealed autophagosome was caused by inhibition autophagic flux. Moreover, exposure did not affect autophagosome–lysosome fusion rPT Next, we found lysosomal...
Fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) have been shown to differ normal lung fibroblasts in functional behaviors that contribute the pathogenesis of IPF, including expression contractile proteins and proliferation, but how such vary matrices stiffness matched fibrotic tissue remains unknown. Here, we tested whether pathologic changes matrix control IPF tissue-derived fibroblast functions, compared relative efficacy mechanical cues an antifibrotic lipid mediator,...
Ingestion of aristolochic acid (AA) can cause AA nephropathy (AAN), in which excessive death tubular epithelial cells (TECs) characterize the acute phase. forms adducts with DNA, may lead to TEC apoptosis via p53-mediated signaling. We tested this hypothesis both by studying p53-deficient mice and blocking p53 TECs its inhibitor pifithrin-alpha. induced AAN wild-type mice, resulting massive apoptotic necrotic renal failure; deficiency or pharmacologic inhibition attenuated injury. In vitro,...