A5100389031- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple and Secondary Primary Cancers
- Cancer-related gene regulation
- Immune cells in cancer
- Circular RNAs in diseases
- COVID-19 diagnosis using AI
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Medical Imaging and Pathology Studies
- Medical Imaging Techniques and Applications
- Central Venous Catheters and Hemodialysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Central South University
2015-2025
Shanghai First People's Hospital
2022-2025
Second Xiangya Hospital of Central South University
2015-2025
Chengdu University of Traditional Chinese Medicine
2025
Southwest Medical University
2024-2025
Wenzhou Medical University
2020-2025
Shanghai Changzheng Hospital
2021-2025
Shanghai Jiao Tong University
2022-2025
Guangxi Medical University
2024-2025
Jiangsu University
2025
The regulatory loop between long noncoding RNAs (lncRNAs) and microRNAs has a dynamic role in transcriptional translational regulation, is involved cancer. However, the circuitry lncRNAs tumorigenesis remains elusive. Here we demonstrate that nuclear lncRNA LINC00336 upregulated lung cancer functions as an oncogene by acting competing endogenous RNA (ceRNAs). bound RNA-binding protein ELAVL1 (ELAV-like 1) using nucleotides 1901–2107 of RRM interaction domain key amino acids (aa) (aa...
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
Ferroptosis is an iron-dependent cell death process that plays important regulatory roles in the occurrence and development of cancers, including hepatocellular carcinoma (HCC). Moreover, molecular events surrounding aberrantly expressed long non-coding RNAs (lncRNAs) drive HCC initiation progression have attracted increasing attention. However, research on ferroptosis-related lncRNA prognostic signature patients with still lacking. In this study, association between differentially lncRNAs...
We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms tube stability well profibrogenic effects vitro vivo. While BSA-dispersed tubes were a potent inducer pulmonary fibrosis, PF108 coating protected from damaging lysosomal membrane initiating sequence cooperative cellular events that play role pathogenesis fibrosis. Our results suggest could serve safer design approach MWCNTs.
Abstract Background The tumor microenvironment is a crucial determinant in progression. Interstitial extracellular matrix (ECM), such as type I collagen (Col-1), aberrantly enriched the and promotes Long intergenic non-coding RNAs (lincRNA) are new family of regulatory that modulate fundamental cellular processes via diverse mechanisms. Findings We investigated whether expression lincRNAs was regulated by promoting Col-1. In three-dimensional organotypic culture model using reconstituted...
The production of pyrogenic (fumed) silica is increasing worldwide at a 7% annual growth rate, including expanded use in food, pharmaceuticals, and other industrial products. Synthetic amorphous silica, fumed has been generally recognized as safe for food products by the Food Drug Administration. However, emerging evidence from experimental studies now suggests that could be hazardous due to its siloxane ring structure, high silanol density, "string-of-pearl-like" aggregate which combine...
The gasdermin (GSDM) superfamily has been demonstrated to consist of several important molecules that modulate multifunctional signal processes, such as cell pyroptosis. In this research, the roles GSDM on occurrence and prognosis lung adenocarcinoma (LUAD) were evaluated using integrative bioinformatic analyses in vitro methods. Here, data from platforms revealed GSDMC is significantly upregulated LUAD tissues lines. Real‑time fluorescence quantitative PCR (qPCR) was obviously...
Background: LncRNAs have been shown to play essential roles in cancer therapeutic response. However, the detailed mechanism of lncRNAs temozolomide (TMZ) resistance glioblastoma (GBM) remain be elucidated. Methods: To elucidate maintaining TMZ resistance, we constructed two TMZ-resistant GBM cell lines (T98G-R/U118-R). from four public datasets were reanalyzed, and candidate lncRNA ADAMTS9-AS2 was evaluated TMZ-treated patients vitro lines. Results: Reanalysis expression profiles identified...
Routine clinical surveillance involves serial radiographic imaging following radical surgery in localized non-small cell lung cancer (NSCLC). However, such can detect only macroscopic disease recurrence and is frequently inconclusive. We investigated if detection of ctDNA before after resection NSCLC identifies the patients with risk relapse, furthermore, informs about response to management.We recruited a total 77 patients. A high-throughput 127 target-gene capture technology...
Lung cancer is the leading cause of deaths worldwide. Accurately diagnosing malignancy suspected lung nodules paramount clinical importance. However, to date, pathologically-proven nodule dataset largely limited and highly imbalanced in benign malignant distributions. In this study, we proposed a Semi-supervised Deep Transfer Learning (SDTL) framework for benign-malignant pulmonary diagnosis. First, utilize transfer learning strategy by adopting pre-trained classification network that used...
Ferroptosis is an iron-dependent oxidative, nonapoptotic form of regulated cell death caused by the destruction redox homeostasis. Recent studies have uncovered complex cellular networks that regulate ferroptosis. GINS4 a promoter eukaryotic G 1 /S - cycle as regulator initiation and elongation DNA replication, but little known about its impact on Here, we found was involved in regulation ferroptosis lung adenocarcinoma (LUAD). CRISPR/Cas9-mediated KO facilitated Interestingly, depletion...
Abstract Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the microenvironment (TME). However, function mechanisms of tumor-infiltrating TLSs MIBC need be explored further. Methods We performed single-cell RNA sequencing analysis 11,612 55,392 T from 12 patients found naïve cells, proliferating plasma...
New types of foldamer scaffolds are formidably challenging to design and synthesize, yet highly desirable as structural mimics peptides/proteins with a wide repertoire functions. In particular, the development peptidomimetic helical foldamers holds promise for new biomaterials, catalysts, drug molecules. Unnatural l-sulfono-γ-AApeptides were recently developed shown have potential applications in both biomedical material sciences. However, d-sulfono-γ-AApeptides, enantiomers...
Abstract The lncRNA HOTAIR is a critical regulator of cancer progression. Chromatin remodeling factor LSH for normal development plants and mammals. However, the underlying mechanisms causing this in are not entirely clear. functional diversification FOXA1 FOXA2 contributes to target genes during evolution carcinogenesis. Little known about ratio cancer. We here found that both overexpression was significantly correlated with poor survival patients lung adenocarcinoma (ADC). Also, linked...
Abstract Purpose We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility Chinese indeterminate nodules, we assessed the diagnostic accuracy for early stage plasma samples. Experimental design Patients CT-detected small nodules (diameter ≤ 3.0 cm) were included. Cases ( n = 163) staged IA or IB non-small cell (NSCLC), while controls 83) non-cancerous lesions....
Due to different treatment method and prognosis of subtypes lung adenocarcinomas appearing as ground-glass nodules (GGNs) on computed tomography (CT) scan, it is important classify invasive from non-invasive adenocarcinomas. The purpose this paper build evaluate the performance deep learning networks differentiation invasiveness adenocarcinoma GGNs.This retrospective study included 886 GGNs 794 pathological confirmed patients with for training testing proposed networks. Three networks,...