A5032215892- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- Environmental and Agricultural Sciences
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Diabetes Treatment and Management
- Remote Sensing and Land Use
- Computational Drug Discovery Methods
- Environmental Changes in China
- Bone Metabolism and Diseases
- Tryptophan and brain disorders
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- T-cell and B-cell Immunology
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Gut microbiota and health
- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Sarcoma Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
Guangxi Medical University
2020-2025
Guangxi University
2021
Abstract A comprehensive cellular anatomy of normal human kidney is crucial to address the origins renal disease and cancer. Some diseases may be cell type-specific, especially tubular cells. To investigate classification transcriptomic information kidney, we rapidly obtained a single-cell suspension conducted RNA sequencing (scRNA-seq). Here, present scRNA-seq data 23,366 high-quality cells from kidneys three donors. In this dataset, show 10 clusters Due high quality information, proximal...
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS, deeper understanding its complex tumor microenvironment (TME) required. the present study, tissues were isolated from six patients then subjected single-cell RNA sequencing (scRNA-seq) using 10× Genomics platform. Multiplex immunofluorescence staining was subsequently used validate subsets identified by scRNA-seq....
Abstract Background Muscle-invasive bladder cancer (MIBC) is a highly aggressive disease with poor prognosis. B cells are crucial factors in tumor suppression, and tertiary lymphoid structures (TLSs) facilitate immune cell recruitment to the microenvironment (TME). However, function mechanisms of tumor-infiltrating TLSs MIBC need be explored further. Methods We performed single-cell RNA sequencing analysis 11,612 55,392 T from 12 patients found naïve cells, proliferating plasma...
Bladder cancer is the most prevalent malignancy of urinary tract, with significant advancements in treatment achieved over recent decades. Nonetheless, immunological mechanisms underlying bladder progression remain elusive, and only a limited number patients derive benefit from current immune checkpoint inhibitors. Here, we conducted single-cell RNA sequencing analysis 44,022 cells peripheral blood mononuclear cell samples healthy donor. Our findings indicated that proportions T neutrophils...
The molecular mechanisms involved in the prostate cancer and their relationship with immune cell infiltration are not fully understood. patients undergoing standard androgen deprivation therapy eventually develop castration resistant (CRPC) for which there is no effective treatment currently available, hub genes this process remain unclear.To study systematically comprehensively.Differentially expressed (DEGs) of were screened Cancer Genome Atlas (TCGA) database. Gene Ontology (GO) Kyoto...
Altered composition of the gut microbiota has been observed in many neurodegenerative diseases. LanCL1 proven to protect neurons and reduce oxidative stress. The present study was designed investigate alterations knockout mice interactions between bacteria brain. Wild-type on a normal chow diet were evaluated at 4 weeks 8–9 age. 16s rRNA sequence untargeted metabolomics analyses performed changes faeces metabolites. Real-time polymerase chain reaction analysis, AB-PAS staining TUNEL assay...
Abstract Various cells within the adrenal microenvironment are important in maintaining body homeostasis. However, our understanding of disease pathogenesis is limited by an incomplete molecular characterization cell types responsible for organ's multiple homeostatic functions. We report a cellular landscape human gland using single‐cell RNA sequencing. reveal characteristic features and found immune activation nonimmune endothelial cells. also that abundant occupied lot space gland....
Abstract The precipitation characteristics in Hangzhou of Zhejiang Province, China under the background global climate change are analyzed using meteorological observation data obtained from base station this study. We investigate several aspects, such as centennial trend, seasonal change, periodicity and variation extreme precipitation. Our results show a linear decreasing trend obvious interdecadal on timescale. Significantly increased amplitude fluctuation was observed since beginning...
Abstract Background: As the main active ingredient of Semen Vaccariae, vaccarin is a flavonoid glycoside useful for prevention and treatment numerous diseases. Our previous study found that can reduce osteolysis-induced titanium by inhibiting osteoclast formation. However, issue whether prevent treat postmenopausal osteoporosis remains unclear. Method: In this study, we explored mechanism action via network pharmacological approach. We identified intersecting targets osteoporosis-related...