A5101566945- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Cancer Cells and Metastasis
- interferon and immune responses
- Contact Dermatitis and Allergies
- Total Knee Arthroplasty Outcomes
- Cancer-related gene regulation
- Cannabis and Cannabinoid Research
- Prostate Cancer Treatment and Research
- Bone Metabolism and Diseases
- Cancer Research and Treatments
- Curcumin's Biomedical Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Osteoarthritis Treatment and Mechanisms
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Lower Extremity Biomechanics and Pathologies
Guangxi Medical University
2010-2025
First Affiliated Hospital of GuangXi Medical University
2010-2024
Kumamoto University
2006-2010
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS, deeper understanding its complex tumor microenvironment (TME) required. the present study, tissues were isolated from six patients then subjected single-cell RNA sequencing (scRNA-seq) using 10× Genomics platform. Multiplex immunofluorescence staining was subsequently used validate subsets identified by scRNA-seq....
The synergistic effect of antibacterial and anti-inflammatory is needed to overcome the problem wound healing difficulties. Based on favorable zinc ions (Zn2+) physicochemical properties metal organic frameworks (MOFs), we prepared nanosized zinc-based MOF: Zn-BTC with ability slowly release Zn2+. In cellular levels, possessed lower toxicity fibroblasts enhanced capacity cell proliferation migration. It also had good bactericidal multiple drug-resistant bacteria by reducing 41.4% MRSA 47.2%...
The lung is the primary organ for metastasis of osteosarcoma. Although application neoadjuvant chemotherapy and surgery has remarkably improved survival rate patients with osteosarcoma, prognosis still poor those metastasis. In this study, we performed further bioinformatics analysis on single-cell RNA sequencing (scRNA-seq) data published before, containing 75,317 cells from two osteosarcoma five normal tissues. First, classified 17 clusters, including macrophages, T cells, endothelial so...
Osteosarcoma (OS) is the most common primary malignant bone tumor and highly prone to metastasis. OS can metastasize lymph node (LN) through lymphatics, metastasis of cells reestablishes immune landscape LN, which conducive growth cells. However, mechanism LN osteosarcoma remodeling metastatic (MLN) microenvironment not clear.
Cerium oxide (CeO
Abstract Cannabidiol (CBD) is a non‐intoxicating cannabinoid from cannabis sativa that has demonstrated efficacious against inflammation, which can be considered as potential drug for arthritis treatment. However, the poor solubility and low bioavailability limit its clinical application. Here, we report an effective strategy to fabricate Cannabidiol‐loaded poly(lactic‐co‐glycolic acid) copolymer (CBD‐PLGA) nanoparticles (NPs), with spherical morphology average diameter of 238 nm. CBD was...
Abstract The presence of excessive reactive oxygen species (ROS) at a skin wound site is an important factor affecting healing. ROS scavenging, which regulates the microenvironment, essential for In this study, we used novel electrospun PCL/gelatin/arbutin (PCL/G/A) nanofibrous membranes as dressings, with PCL/gelatin (PCL/G) backbone, and plant-derived arbutin (hydroquinone-β-d-glucopyranoside, ARB) effective antioxidant that scavenges inhibits bacterial infection in wounds. loading ARB...
Legg-Calve-Perthes disease (LCPD) is a form of idiopathic femoral head necrosis that can lead to permanent deformities and premature osteoarthritis in children under the age 15. Its pathogenesis utterly remains be clarified. Although many research publications on LCPD have emerged during last few decades, systematic bibliometric analyses these articles been reported. A analysis was performed investigate development processes hotspots, as well collaboration influence among countries,...
Objective Myocardial infarction (MI) is a leading cause of death worldwide, accounting for millions fatalities annually. The injury and repair cardiomyocytes are closely associated with the changes in gene expression. MicroRNAs could serve as potential target MI treatment. This work aims to investigate role miR-3148 mitochondrial dynamics during acute (AMI) specific focus on its regulatory mechanisms mitophagy apoptosis, which reveal therapeutic targets AMI Material Methods MiR-3148 levels...
Pleioblastus amarus (P. amarus) (Keng) Keng f.is widely distributed in the southern region of China and is a medicinal food resource there. Flavonoids are important bioactive components P. play anti-tumour, anti-inflammatory, antioxidation roles. In this study, targeted metabolomics method based on liquid chromatography–mass spectrometry (LC-MS/MS) was used to analyze 35 flavonoids 6 leaf samples shoot amarus, contents 20 were detected. Cynaroside most abundant dry (13.17 μg/g), while...
Abstract Osteosarcoma accounts for a frequently occurring cancer of the primary skeletal system. In osteosarcoma cells, hypoxic microenvironment is commonly observed that drives tumor growth, progression, and heterogeneity. Hypoxia tumor-infiltrating immune cells might be closely related to prognosis osteosarcoma. this study, we aimed determine biomarkers therapeutic targets hypoxia immunity through bioinformatics methods improve clinical patients. We downloaded gene expression data samples...
Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of mammalian cell nuclei. Paraspeckles have been critically involved tumour progression, metastasis and chemoresistance. To this date, there limited findings to suggest that paraspeckles, NEAT1 heterogeneous nuclear ribonucleoproteins (hnRNPs) directly or indirectly play roles osteosarcoma progression. Herein, we analysed NEAT1,...
Background Tumor infiltrating lymphocytes (TILs), the main component in tumor microenvironment, play a critical role antitumor immune response. Few studies have developed prognostic model based on TILs osteosarcoma. Methods ScRNA-seq data was obtained from our previous research and bulk RNA transcriptome TARGET database. WGCNA used to obtain immune-related gene modules. Subsequently, we applied LASSO regression analysis SVM algorithm construct marker genes. What’s more, verified by external...
Abstract Current research suggests that synovial phagocytic cells remove excessive amounts of free oxygen radicals (reactive species [ROS]), thereby preventing damage to tissues. Moreover, ROS may affect the expression growth arrest and DNA inducible α (GADD45A), thus further promoting activation fibroblasts. Male adult rats were assessed for progression collagen‐induced arthritis (CIA) using a macroscopic scoring system hind paws by measuring changes in rat's body weight, activity level...
Osteosarcoma (OS) differentially expressed genes (DEGs) have been predicted using the data portal of Therapeutically Applicable Research to Generate Effective Treatments (TARGET). In this study, we sought identify cell types that specially express key DEGs (MUC1, COL13A1, JAG2, and KAZALD1) in each nine identified populations derived from tissues OS tumors with single-cell RNA-sequencing data. Gene expression levels were pairwise compared between clusters a p value < 0.05 was considered...
Osteosarcoma (OS) is a primary bone tumor with high malignancy and the mechanism of hematogenous metastasis in OS still not clear. The plasma exosomes derived from osteosarcoma play key role process metastasis. Here, we established RNA-seq dataset for lncRNAs, circRNAs mRNAs 10 patients 5 healthy donors. A total 329.52 Gb clean data was obtained. Besides, 1754 lincRNAs, 7096 known 1935 new circRNA identified. Finally, gene expression profiles differentially expressed genes (DEGs) were...
The bystin-like ( BYSL ) gene is expressed in a wide range of eukaryotes and closely associated with tumor progression. However, its function mechanism osteosarcoma remain unclear. Herein, the protein expression clinical role human tissues were assessed. High was positively related to metastasis status poor patient prognosis. Mechanistically, upregulation enhanced Nrf2 under hypoxia cells. MicroRNAs are important epigenetic regulators development. Noteworthy, bioinformatics analysis,...
Toxicity Study of the Volatile Constituents Myoga Utilizing Acute Dermal Irritation Assays and Guinea‐Pig Maximization Test: Qingjun W ei , et al . Department Preventive Environmental Medicine, Graduate School Medical Pharmaceutical Sciences, Kumamoto University — is a fragrant plant which special product Japan cultivated throughout Japan. According to our earlier investigation (unpublished data) myoga cultivators in Japan, 8 35 experienced contact dermatitis harvest season. The purpose this...
Immune infiltration is a prognostic marker to clinical outcomes in various solid tumors. However, reports that focus on bone and soft tissue sarcoma are rare. The study aimed analyze identify how immune components influence prognosis develop novel system for sarcomas.We retrieved the gene expression data from 3 online databases (GEO, TCGA, TARGET). fraction was estimated using CIBERSORT algorithm. After that, we re-clustered samples by K-means constructed immunoscore least absolute shrinkage...
Chemotherapy, a primary treatment for osteosarcoma (OS), has limited knowledge regarding its impact on tumor immune microenvironment (TIME). Here, tissues from 6 chemotherapy-naive OS patients underwent single-cell RNA sequencing (scRNA-seq) and were analyzed alongside public dataset (GSE152048) containing 7 post-chemotherapy tissues. CD45+ (PTPRC+) cells used cell clustering annotation. Changes in composition pre- characterized. Totally, 28,636 high-quality extracted. Following...