Abstract Oxidative stress (OS) reactions are reported to be associated with oncogenesis and tumor progression. However, little is known about the potential diagnostic value of OS in gastric cancer (GC). This study identified hub genes prognosis progression GC illustrated underlying mechanisms. The transcriptome data corresponding clinical information were collected from Cancer Genome Atlas (TCGA) database. Aberrantly expressed between tumors adjacent normal tissues screened, 11...

RNA modifications, including methylation, are widely existed in cutaneous melanoma (CM). Among epigenetic N7-methylguanosine (m7G) is a kind of modification at 5’ cap which participate maintaining the stability mRNA and various cell biological processes. However, there still no study concerning relationship between CM m7G methylation complexes, METTL1 WDR4. Here, long non-coding (lncRNAs) gene expression data from Cancer Genome Atlas (TCGA) database were retrieved to identify...

Ultrawide‐bandgap gallium oxide (Ga 2 O 3 ) is capable of filtering out visible light and selectively responding to the solar‐blind ultraviolet light. However, excessively wide bandgap results in a relatively narrow detection range, which limits operational spectrum device. The intentional introduction other elements modulate energy band Ga can effectively expand its range. Among these, Sn considered an ideal exotic atom due similar electronic structure atomic radius Ga, as well lower...

Daphnetin (DAP) is a traditional Chinese drug usually used to treat cardiovascular diseases. Studies have confirmed the anti-inflammatory, antioxidant, anti-bacterial and insecticidal, anti-tumor neuro-protective effects of DAP. However, its anti-arthritic potential remains unexplored. The aim this study investigate in vitro vivo chondroprotective DAP.The effect DAP on primary rabbit chondrocytes was examined using recombinant human IL-1β for 24 h. For studies, rabbits were randomly divided...

Background Cutaneous melanoma (CM) is a life-threatening destructive malignancy. Pyroptosis significantly correlates with programmed tumor cell death and its microenvironment through active host-tumor crosstalk. However, the prognostic value of pyroptosis-associated gene signatures in CM remains unclear. Methods Gene profiles clinical data patients were downloaded from The Cancer Genome Atlas (TCGA) to identify differentially expressed genes associated pyroptosis overall survival (OS). We...

Osteoarthritis (OA) is a degenerative disease of the cartilage prevalent in middle-aged and elderly demographic. Direct transplantation bone marrow mesenchymal stem cells (BMSCs) or cell-derived chondrocytes into damaged promising therapeutic strategy for OA, but limited by poor survival situ stability chondrocytes. Autophagy unique catabolic pathway conserved across eukaryotes that maintains cellular homeostasis, recycles proteins organelles, promotes survival. The aim this study was to...

Anoikis is a newly discovered form of apoptosis that was originally identified in the extracellular matrix (ECM). Recent studies have reported anoikis central to cancer metastasis. Here, SNCG as hub anoikis-associated gene GC and associated with prognosis patients GC. To screen genes connected GC, database Cancer Genome Atlas (TCGA) employed. For further validating these genes, Gene Expression Omnibus (GEO) dataset applied, Western blotting quantitative Real-Time PCR were carried out....

Oxidative stress is commonly associated with osteoarthritis (OA). Lycopene (LYC), a natural carotenoid compound, an effective antioxidant potential cartilage‐protecting actions. However, how it affects hydrogen peroxide (H 2 O )‐induced damage to the cartilage unclear. In this study, in vitro oxidative model was developed via treating primary chondrocytes H . Western blot, immunohistochemistry, and quantitative RT‐PCR (qRT‐PCR) were used assess levels of related factors. Reactive oxygen...

Osteoarthritis (OA) is the most common chronic degenerative joint disorder globally that characterized by synovitis, cartilage degeneration, space stenosis, and sub-cartilage bone hyperplasia. However, pathophysiologic mechanisms of OA have not been thoroughly investigated.In this study, we conducted various bioinformatics analyses to identify hub biomarkers immune infiltration in OA. The gene expression profiles synovial tissues from 29 healthy controls 36 samples were obtained omnibus...

Abstract Current research suggests that synovial phagocytic cells remove excessive amounts of free oxygen radicals (reactive species [ROS]), thereby preventing damage to tissues. Moreover, ROS may affect the expression growth arrest and DNA inducible α (GADD45A), thus further promoting activation fibroblasts. Male adult rats were assessed for progression collagen‐induced arthritis (CIA) using a macroscopic scoring system hind paws by measuring changes in rat's body weight, activity level...

Abstract Bladder cancer (BC) is one of the most common malignancies worldwide. Several biomarkers related to prognosis patients with BC have previously been identified. However, these prognostic models use only gene and are thus not reliable or accurate enough. The purpose our study was develop an innovative signature that has greater value in BC. So, this study, we performed mRNA expression profiling glycolysis-related genes (n = 407) cohorts by mining data from Cancer Genome Atlas (TCGA)...

As a novel cell death modality, oxeiptosis is mainly caused by oxidative stress. However, the associations of uterine corpus endometrial carcinoma (UCEC) with oxeiptosis-associated long non-coding RNAs (lncRNAs) are unknown. Here, to identify hub lncRNAs in UCEC, we collected data for and gene expression UCEC from The Cancer Genome Atlas (TCGA) database. Then, lncRNA risk signature was constructed, its prognostic value further evaluated. Finally, levels HOXB-AS3 were validated quantitative...

Osteoarthritis (OA) is a degenerative disease of the cartilage that prevalent in middle-aged and elderly demography. Polydatin (PD), natural resveratrol glucoside, has shown significant anti-inflammatory anti-arthritic potential previous studies. This study was designed to evaluate therapeutic properties PD vitro vivo, elucidate their underlying mechanisms. The expression levels all relevant factors were evaluated by qRT-PCR, western blotting, immunohistochemistry (IHC) where suitable....

Excess Cu can cause cell death as a cofactor for essential enzymes. The relationship between cuproptosis-associated genes (CAGs) and breast cancer (BR) is not completely investigated. Here, the transcriptome expression mutation profile data of BR samples from Cancer Genome Atlas database were retrieved to identify CAGs. Patients with clustered using consensus clustering. A least absolute shrinkage selection operator analysis was then performed construct CAGs risk signature. As result, all 13...

Soft tissue sarcomas (STSs) are heterogeneous at the clinical with a variable tendency of aggressive behavior. In this study, we constructed specific DNA methylation-based classification to identify distinct prognosis-subtypes STSs based on methylation spectrum from TCGA database. Eventually, samples were clustered into 4 subgroups, and their survival curves each other. Meanwhile, in subgroup reflected differentially several features. Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes...

Abstract Bone metastasis caused by breast cancer leads to significant complications in treatment, and the resulting osteolysis considerably affects patients’ overall survival quality of life. Gö6983 is a broad spectrum protein kinase C inhibitor. In this study, based on our finding that inhibits osteolysis, we applied MDA‐MB‐231 cancer‐induced mouse bone model. And found has strong inhibitory effect tumorigenic model promoting mitochondrial apoptosis pathway. Our therefore, demonstrates...

Abstract Rheumatoid arthritis (RA) is one of the most common autoimmune joint disorders globally, but its pathophysiological mechanisms have not been thoroughly investigated. Pyroptosis significantly correlates with programmed cell death. However, targeting pyroptosis has considered as a therapeutic strategy in RA due to lack systematic studies on validated biomarkers. The present study aimed identify hub biomarkers and immune infiltration RA. gene expression profiles synovial tissues were...

Pyroptosis is a form of inflammatory programmed cell death. However, because no specific molecular biomarker, pyroptosis has not been considered as novel therapeutic method to treat cutaneous melanoma (CM). Here, we identified genes that associate with the prognosis CM patients and constructed an effective model for prognostic prediction patients. To identify related are differentially expressed in CM, obtained gene expression data normal skin tissues from Cancer Genome Atlas Genotype-Tissue...

Abstract Background Skin cutaneous melanoma (SKCM) is a prevalent skin cancer whose metastatic form dangerous due to its high morbidity and mortality. Previous studies have systematically established the vital role of oxidative stress (OS) in progression. This study aimed identify prognostic OS genes closely associated with SKCM illustrate their potential mechanisms. Methods Transcriptome data corresponding clinical traits patients were retrieved from The Cancer Genome Atlas (TCGA) Gene...