A5113820274- Skin Protection and Aging
- Smart Agriculture and AI
- Autophagy in Disease and Therapy
- Advanced Mathematical Physics Problems
- Aortic aneurysm repair treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Remote Sensing and LiDAR Applications
- Dental Implant Techniques and Outcomes
- Genomics, phytochemicals, and oxidative stress
- Neuroscience and Neuropharmacology Research
- Climate Change and Health Impacts
- Anesthesia and Neurotoxicity Research
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Endoplasmic Reticulum Stress and Disease
- Soil Mechanics and Vehicle Dynamics
- Tryptophan and brain disorders
- Intensive Care Unit Cognitive Disorders
- Nutrition and Health in Aging
- RNA Interference and Gene Delivery
- Agricultural Engineering and Mechanization
- Psoriasis: Treatment and Pathogenesis
- Ultrasound in Clinical Applications
China Medical University
2015-2025
First Affiliated Hospital of Fujian Medical University
2015-2025
Zhejiang Sci-Tech University
2025
Fujian Medical University
2015-2025
Tianjin Research Institute of Water Transport Engineering
2020-2025
Tianjin University
2025
Ruijin Hospital
2022-2025
Ministry of Transport
2025
Shanghai Mental Health Center
2025
Xinjiang Academy of Agricultural and Reclamation Science
2022-2024
To date, few studies have focused on the influence of indoor air pollution cognitive impairment. Thus, we aimed to explore association household fuel use, major cause pollution, with functioning among a sample middle-aged and older Chinese individuals.A total 10,372 8,397 participants from China Health Retirement Longitudinal Study (CHARLS) were enrolled in cross-sectional follow-up analyses, respectively. Cognitive was evaluated via structured questionnaire three dimensions: orientation...
Observational studies have reported inconsistent results on the association between fruit and vegetable intake risk of pancreatic cancer. We carried out a meta-analysis epidemiological to summarize available evidence. searched PubMed, Scopus, ISI Web Science databases for relevant published until end January 2015. Fixed-effects random-effects models were used estimate summary relative risks (RRs) 95% confidence intervals (CIs) associations A total 15 case-control studies, eight prospective...
Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly population. Neuroinflammation induced by amyloid-β (Aβ) aggregation considered to be critical factor underlying AD pathological mechanisms. Alternatively activated (M2) macrophages/microglia have been repor ted neuroprotective effects disease. In this study, we characterized of M2 macrophage transplantation model rats and investigated Intracerebroventricular injection Aβ1 - 42 was used resulted cognitive...
In the present study, we examined mechanisms of oxaliplatin-induced drug resistance in human colorectal cancer cell lines HT29 and HCT116. Our results demonstrate a significant autophagy expression CRC cells after an oxaliplatin treatment. Administration to significantly enhanced HMGB1, which regulated response negatively regulate apoptosis. Moreover, decreased -induced increased apoptosis level were detected stable harboring HMGB1 shRNA. Then noted that induced extracellular...
Isometric handgrip resistance exercise, a nonpharmacological lifestyle modification, has been recommended as first-line treatment for hypertension. This study aimed to examine the relationship of strength blood pressure and risk hypertension.The responses examination 4597 participants in National Health Nutrition Examination Survey (NHANES) were analyzed this study. Systolic (SBP) diastolic (DBP) transformed age- sex-specific z-scores. Handgrip was adjusted by weight (kg) converted an...
Here we evaluated the anti-cancer activity of aqueous Oldenlandia diffusa (OD) extracts (ODE) in colorectal cancer (CRC) cells. We showed that ODE exerted potent anti-proliferative, cytotoxic and pro-apoptotic activities against a panel established CRC lines (HCT-116, DLD-1, HT-29 Lovo) primary (patient-derived) human activated AMP-activated protein kinase (AMPK) signaling, which led to subsequent mTORC1 inhibition Bcl-2/HIF-1α downregulation In ODE-treated cells, AMPKα1 formed complex with...
To evaluate clinical and radiographic outcomes following free gingival grafts (FGGs) around implants with limited keratinized mucosa (KM) during 18 months follow-up compared to oral prophylaxis without augmentation.This prospective controlled randomized blind study investigated 41 displaying lack of KM in 28 subjects. After baseline examination, 14 subjects the experimental group received FGGs followed by control only. The width KM, level mucosal margin, pocket depths, plaque index, index...
Head and neck squamous cell carcinoma (HNSCC) represents more than 5% of all cancers diagnosed annually in United States around the world. Despite advances management patients with this disease, survival has not been significantly improved, search for potential alternative therapies is encouraging. Here we demonstrate that deguelin administration causes a significant HNSCC death. Deguelin induces both apoptosis autophagy by modulating multiple signaling pathways cultured cells. inhibits Akt...
The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads Akt phosphorylation at Ser-473, which is important for the carcinogenic effects excessive sun exposure. present study investigated underlying mechanism Ser-473 by UVB radiation.We found that DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and mammalian target rapamycin (mTOR) complex 2 (mTORC2) were both required UVB-induced in keratinocytes. Inhibition DNA-PKcs activity via its inhibitor NU7026, a...
Exposure to ultraviolet (UV) light reduces levels of type I collagen in the dermis and results human skin damage premature aging (photoaging). This leads a wrinkled appearance through inhibition transforming growth factor‑β (TGF‑β)/Smad signaling. UV irradiation increases degradation upregulating matrix metalloproteinase (MMP) expression. Astragaloside IV (AST) is one major active components extracted from Astragalus membranaceus. However, its multiple anti‑photoaging effects remain be...
Recent published studies suggest that increasing levels of ceramides enhance the chemo‐sensitivity curcumin. Using in vitro approaches, we analyzed impact sphingosine kinase‐1 ( S ph K ‐1) inhibition on ceramide production, and evaluated SphK1 inhibitor II SKI ‐ ) as a potential curcumin chemo‐sensitizer ovarian cancer cells. We found 1 is overexpressed patients' tumor tissues cultured cell lines. Inhibition by or RNA interference i) knockdown dramatically enhanced curcumin‐induced apoptosis...
Abstract Introduction This study is an extended follow‐up of a randomized controlled trial that evaluated 18‐month outcomes following free gingival grafts (FGGs) around implants with <2 mm keratinized mucosa (KM) compared to without KM augmentation. Materials and Methods Follow‐up data were obtained over 48 months from 18 in the FGG group (11 subjects) 8 no‐surgery (7 within control group. FGGs performed after for group; these constituted delayed (5 subjects). The width KM, mucosal...
In the context of evolving landscape reduction in carbon emissions and integration renewable energy, this study uses system dynamics (SD) modeling to explore interconnected trading (CT), tradable green certificate (TGC) trading, electricity markets. Using differential equations with time delays, provides a comprehensive analysis structural relationships feedback mechanisms within between these Key findings reveal intricate interplay prices, prices under various coupling mechanisms. For...