A5100428092- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Air Quality and Health Impacts
- RNA Research and Splicing
- Cell Adhesion Molecules Research
- Epigenetics and DNA Methylation
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Inflammasome and immune disorders
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Prostate Cancer Treatment and Research
- Immune cells in cancer
- Climate Change and Health Impacts
- Ocular Infections and Treatments
- Cancer-related gene regulation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA and protein synthesis mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Treatment and Pharmacology
Sichuan Agricultural University
2020-2025
Nanjing Medical University
2011-2025
Jiangsu Province Hospital
2011-2025
Liaocheng University
2012-2025
Shanghai Jiao Tong University
2013-2025
Ruijin Hospital
2021-2025
Shanghai Institute of Hematology
2021-2025
Huazhong University of Science and Technology
2023-2025
Shandong First Medical University
2017-2025
Tongji Hospital
2020-2025
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly sense immune activation, yet their potential interplay with autoreactive in MS unknown. Here, we report that bone HSPCs are skewed toward myeloid lineage concomitant clonal expansion patients. Lineage tracing experimental encephalomyelitis, mouse model MS, reveals remarkable myelopoiesis an augmented output neutrophils...
Abstract Inflammasome complexes are pivotal in the innate immune response. The NLR family pyrin domain containing protein 3 (NLRP3) inflammasome is activated response to a broad variety of cellular stressors. However, primary and converging sensing mechanism by NLRP3 receptor initiating assembly remains ill defined. Here, we demonstrate that activators primarily converge on disruption endoplasmic reticulum–endosome membrane contact sites (EECS). This defect causes endosomal accumulation...
Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients. However, it is still unclear whether this applies older individuals with mild impairment (MCI). We aimed explore the effects of probiotic supplementation on multiple neural behaviors adults MCI. Forty-two MCI patients (age > 60 years) randomly divided into two groups and consumed either probiotics (n=21) or placebo for 12 weeks. Various scale scores, gut microbiota measures serological...
Self-assembled molecules (SAMs) as hole transport layers (HTLs) on light-managing textured substrates promise great commercial potential for high-efficiency inverted perovskite solar cells (PSCs). However, the inhomogeneous distribution and disordered packing...
Tumor integrin β1 (ITGB1) contributes to primary tumor growth and metastasis, but its specific roles in extravasation have not yet been clearly elucidated. In this study, we engineered a three-dimensional microfluidic model of the human microvasculature recapitulate environment wherein takes place assess consequences depletion cancer cells. Combined with confocal imaging, these tools allowed us decipher detailed morphology transmigrating cells associated endothelial vitro at high...
More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism follicular remains to be elucidated. In this study, we explored microRNA (miRNA) regulation porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, differentially expressed miRNAs were selected analyzed. We found that miR-26b, which upregulated during atresia, increased number DNA breaks promoted granulosa cell apoptosis by targeting ataxia...
This study was designed to investigate the in vitro and vivo antioxidant activities of inulin. The assays demonstrated that inulin, including DPPH radical scavenging activity, ABTS activity ferric reducing power, were weak significantly lower than those Vitamin C (P < 0.05). influence dietary supplementation with inulin on status laying hens evaluated assays. results indicated quadratically improved egg production rate 0.01). enzyme serum, SOD, CAT, GSH-Px, total capacity increased as levels...
An intense stimulus can cause death of odontoblasts and initiate odontoblastic differentiation stem/progenitor cell populations dental pulp cells (DPCs), which is followed by reparative dentin formation. However, the mechanism during formation remains unclear. This study was to determine role β-catenin, a key player in tooth development, formation, especially differentiation. We found that β-catenin expressed odontoblast-like DPCs beneath perforation site after direct capping. The expression...
Abundant miRNAs have been identified in milk and mammary gland tissues of different species. Typically, RNA can be extracted from fractions including fat, whey cells the mRNA transcriptome could serve as an indicator tissue. However, it has not adequately validated if miRNA any fraction representative that The objectives this study were to (1) characterize expression spectra three fractions- cells; (2) compare miRNome profiles (fat, cells) with tissue miRNome, (3) determine which profile a...
Abstract The ability of a cancer cell to migrate through the dense extracellular matrix within and surrounding solid tumor is critical determinant metastasis. Macrophages enhance invasion metastasis in microenvironment, but basis for their effects not fully understood. Using microfluidic 3D migration assay, we found that presence macrophages enhanced speed persistence metalloproteinases (MMP)-dependent fashion. Mechanistic investigations revealed macrophage-released TNFα TGFβ1 mediated...
Abstract Background & aims Emerging evidence supports ambient fine particulate matter (PM 2.5 ) exposure is associated with insulin resistance (IR) and hepatic lipid accumulation. In this study, we aimed to evaluate the sex-dependent vulnerability in response PM investigate underlying mechanism by which modulates metabolism. Methods Both male female C57BL/6 mice were randomly assigned or filtered air for 24 weeks via a whole body system. High-coverage quantitative lipidomics approaches...
Ports are major energy consumers and carbon emission producers. Developing integrated port systems (IPES) is the key to solve this problem. The forms in an IPES include electricity, hydrogen, heat natural gas. Hydrogen can be generated from surplus renewable energies via water electrolysis, thus power previously oil-fueled equipment. Meanwhile, remaining hydrogen converted gas by methanation reaction. By using fuel cells, turbine, boiler boiler, supply electrical loads area, forming a...
Abstract Bacteria-triggered sepsis is characterized by systemic, uncontrolled inflammation in affected individuals. Controlling the excessive production of pro-inflammatory cytokines and subsequent organ dysfunction remains challenging. Here, we demonstrate that Spi2a upregulation lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages reduces myocardial impairment. In addition, exposure to LPS upregulates lysine acetyltransferase, KAT2B, promote METTL14 protein stability through...
Abstract Background There is insufficient evidence for the ability of vitamin K2 to improve type 2 diabetes mellitus symptoms by regulating gut microbial composition. Herein, we aimed demonstrate key role microbiota in improvement impaired glycemic homeostasis and insulin sensitivity intervention. Methods We first performed a 6-month RCT on 60 T2DM participants with or without MK-7 (a natural form K2) In addition, conducted transplantation MK-7-regulated diet-induced obesity mice 4 weeks....
Limited data exist for global prevalence of claudin 18 isoform 2 (CLDN18.2) positivity and association CLDN18.2 status with clinical tumor characteristics in patients locally advanced (LA) unresectable or metastatic gastric gastroesophageal junction (mG/GEJ) adenocarcinoma. We report (phase 3; SPOTLIGHT, NCT03504397; GLOW, NCT03653507) concordance between a subset pair-matched samples 2, ILUSTRO, NCT03505320; phase 1, NCT03528629) from studies zolbetuximab.
Introduction: The toxicity of arsenic is widely recognized globally, mainly harming human health by polluting water, soil, and food. However, its formulations can also be used for the clinical treatment diseases such as leukemia tumors. Arsenic has been a drug in China over 2,400 years, with examples arsenic-containing realgar mentioned Shennong’s Herbal Classic. We have reviewed references on past thirty years found that research focused clinical, pharmacological, toxicological aspects....
Background and purpose Approximately 25% of acute large vessel occlusive (LVO) ischaemic strokes are unknown thrombotic origin, there is a need to establish the aetiology guide subsequent preventative measures. The aim this study was quantify thrombus composition in patients with LVO explore associations between stroke aetiology. Methods Thrombi were extracted from 132 stroke. Erythrocytes, leucocytes F+P (fibrin+platelet) proportions assessed tissue sections stained H&E, while CD3 + T...