A5100744756- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Cardiac Ischemia and Reperfusion
- Plant-based Medicinal Research
- Flavonoids in Medical Research
- Lipid metabolism and disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Ginkgo biloba and Cashew Applications
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Saffron Plant Research Studies
- Cardiac electrophysiology and arrhythmias
- Healthcare and Venom Research
- Atherosclerosis and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Cancer, Lipids, and Metabolism
- Chromatography in Natural Products
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
Xiyuan Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Hunan University of Science and Technology
2011-2024
Beijing Institute of Technology
2024
Guangdong Pharmaceutical University
2024
China Academy of Chinese Medical Sciences
2012-2023
Western Sydney University
2018-2022
Henan Provincial Center for Disease Control and Prevention
2012-2021
Xingtai Medical College
2012-2019
Hebei Medical University
2012-2019
Collaborative filtering is one of widely used Web service recommendation techniques. In QoS-based recommendation, predicting missing QoS values services often required. There have been several methods based on collaborative filtering, but seldom they considered locations both users and in services. Actually, or do remarkable impacts factors, such as response time, throughput, reliability. this paper, we propose a method location-aware to recommend by incorporating Different from existing...
Collaborative filtering is one of widely used Web service recommendation techniques. There have been several methods selection and based on collaborative filtering, but seldom they considered personalized influence users services. In this paper, we present an effective method for recommendation. A key component techniques computation similarity measurement Different from the Pearson Correlation Coefficient (PCC) measurement, take into account services when computing between Based model...
Organic acids in Chinese herbs, the long-neglected components, have been reported to possess antioxidant, anti-inflammatory, and antiplatelet aggregation activities; thus they may potentially protective effect on ischemic heart disease. Therefore, this study aims investigate effects of two organic acids, that is, citric acid L-malic acid, which are main components Fructus Choerospondiatis, myocardial ischemia/reperfusion injury underlying mechanisms. In vivo rat model injury, we found...
// Cuixiang Zhang 1,2,* , Tian Lan 3,* Jincai Hou 1,2 Juan Li 4,5 Rende Fang Zhicheng Yang 4 Min 6 Jianxun Liu and Bing 1 Institute of Basic Medical Sciences Xiyuan Hospital, China Academy Chinese Sciences, Beijing 110300, 2 Key Laboratory Pharmacology Materia Medica, Beijing110300, 3 Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou 510006, Department Clinical pharmacy, School Pharmacy, 5 Bioactive Substances, Guangzhou, of health statistics, Public...
Breast cancer is still the most common malignant tumor that threatens female's life in world, especially triple-negative breast (TNBC), one of difficult subtypes. Lack targeted therapies brings about urgent demand for novel treatments. In this study we aim to investigate anti-tumor activity Berberine (BBR), a Chinese plant-derived alkaloid, against TNBC cell line MDA-MB-231 and elucidate its mechanism referring anti-inflammation. Cell inhibition rate was measured by Proliferation Assay,...
Ischemic injury to the heart induces mitochondrial dysfunction due increasing oxidative stress. MG53, also known as TRIM72, is highly expressed in striated muscle, secreted a myokine after exercise, and essential for repairing damaged plasma membrane of many tissues by interacting with lipid phosphatidylserine (PS). We hypothesized MG53 could preserve integrity an ischemic event binding mitochondrial-specific lipid, cardiolipin (CL), mitochondria protection prevent mitophagy. Fluorescent...
Shuangshen Ningxin Formula (SSNX) is a traditional Chinese medicine formula used to treat myocardial ischemia-reperfusion injury (MIRI). A randomized controlled trial previously showed that SSNX reduced cardiovascular events, and experiments have also verified attenuated (I/R) injury. However, the mechanism of in treatment microvascular I/R still unclear.
// Juan Li 1, * , Tian Lan 2, Cuixiang Zhang 3, 4, Cheng Zeng 1 Jincai Hou 4 Zhicheng Yang 5 Min 6 Jianxun Liu Bing Clinical Pharmacy Department, Guangdong Pharmaceutical University, Guangzhou 510006, China 2 Vascular Biology Research Institute, 3 Institute of Basic Medical Sciences Xiyuan Hospital, Academy Chinese Sciences, Beijing 110300, Key Laboratory Pharmacology Materia Medica, Department Pharmacology, School Pharmacy, Health Statistics, Public Health, These authors contributed equally...
Background/Aims: Ischemic stroke is a leading cause of long-term disability. To date, there no effective treatment for stroke. Previous studies have shown that Ginkgo biloba extract has protective effects against neurodegenerative disorders. In this present study, we sought to test the potential role an active component extract, bilobalide, in rat model middle cerebral artery occlusion (MCAO). Methods: A MCAO was used Bilobalide B on protection. TTC staining performed evaluate infarct size...
High mobility group box 3 (HMGB3) is strongly involved in oncogenesis a variety of cancers. In the present study, we have explored role HMGB3 glioblastoma multiforme (GBM) tumorigenesis and identified microRNAs (miRNAs) miR‐200b‐3p miR‐200c‐3p as negative regulators expression. We began by determining that endogenous expression levels were significantly elevated GBM tissues cell lines. To study function GBM, transfected small‐interfering RNA (siRNA) against into lines U251 LN229. MTT tumour...
Abstract The phenolic components from Radix Salvia miltiorrhizae Bunge, a well‐known herbal medicine (Dan‐Shen in Chinese), have been investigated by high‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC/ESI‐MS/MS). HPLC analyses were performed on reversed‐phase C 18 column using gradient elution. In the ESI spectra predominant [M–H] − ion was observed negative mode and provided molecular information. ESI‐MS/MS of ions used for structural analysis,...
Yiqi Shexue formula (YQSX) is traditionally used to treat primary immune thrombocytopenia (ITP) in clinical practice of traditional Chinese medicine. However, its mechanisms action and molecular targets for treatment ITP are not clear. The active compounds YQSX were collected their identified. ITP-related obtained by analyzing the differential expressed genes between patients healthy individuals. Protein-protein interaction (PPI) data then PPI networks putative visualized merged identify...
Glutamate-induced neurotoxicity is one of the most important pathogenic mechanisms in neurological diseases and widely used as an vitro model for ischemic stroke. Senkyunolide I (SEI), active constituent derived from traditional Chinese medicine Ligusticum chuanxiong Hort. Angelica sinensis (Oliv.) Diels, has been shown to have beneficial effects against focal cerebral ischemia-reperfusion rats. However, underlying SEI-mediated neuroprotection remain not well understood. Thus, we explored...