A5102841006- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Sesquiterpenes and Asteraceae Studies
- Medicinal Plant Extracts Effects
- NF-κB Signaling Pathways
- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Phytochemical Studies and Bioactivities
- Cytokine Signaling Pathways and Interactions
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Phytochemicals and Medicinal Plants
- Immune Response and Inflammation
- Gut microbiota and health
- Plant Toxicity and Pharmacological Properties
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Ferroptosis and cancer prognosis
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Catalysis and Immobilization
- Cancer-related molecular mechanisms research
- Sphingolipid Metabolism and Signaling
- Biochemical Acid Research Studies
- Microbial Natural Products and Biosynthesis
Zhejiang Chinese Medical University
2016-2025
First Hospital of Qinhuangdao
2024
Peking University Third Hospital
2024
Peking University
2024
Zunyi Medical University
2019-2022
Harbin University of Commerce
2008-2021
Ministry of Education of the People's Republic of China
2021
Jilin Vocational College of Industry and Technology
2020
Wuhan University
2014-2018
Hubei Zhongshan Hospital
2014-2018
The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads Akt phosphorylation at Ser-473, which is important for the carcinogenic effects excessive sun exposure. present study investigated underlying mechanism Ser-473 by UVB radiation.We found that DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and mammalian target rapamycin (mTOR) complex 2 (mTORC2) were both required UVB-induced in keratinocytes. Inhibition DNA-PKcs activity via its inhibitor NU7026, a...
Pancreatic cancer remains a challenging disease worldwide. Cryptotanshinone (CPT) is one of the active constituents Salvia miltiorrhiza Bunge and exhibits significant antitumor activities in several human cells. However, efficacy molecular mechanism CPT pancreatic to be elucidated. In present study, effect on proliferation, apoptosis cell cycle BxPC‑3 cells was evaluated. The results demonstrated that inhibited proliferation concentration‑dependent manner, significantly induced arrest....
Michael reaction acceptors (MRAs) are a class of active compounds. There is great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, discover lead compounds for anti-triple-negative breast cancer (TNBC). In this study, glutathione (GSH) was employed, and UPLC-MS screening method developed MRAs. We screened MRAs which can inhibit using STAT3-dependent reporter system. Six sesquiterpene lactones, including new compound Eupalinolide O (1), together with five known...
Sesquiterpene lactones (SLs) are plant‐derived constituents that have been proved to potential antitumour activity. However, the intracellular molecular targets of SLs and underlying mechanisms not well elucidated. Here, we report F1012‐2, a novel SL active fraction, isolated from Eupatorium lindleyanum DC., can significantly inhibit growth triple‐negative breast cancer (TNBC) cells (MDA‐MB‐231 MDA‐MB‐468) but has no obvious inhibitory effect on human mammary epithelial (MCF‐10A). The...
Abstract Purpose Triple-negative breast cancer (TNBC) is the most aggressive subtype with no targeted treatment. The objective of this study was to find new therapeutic agents and appropriate methods overcome limitations TNBC Methods P53 mutant cells were treated eupaformosanin (Eup), a natural compound isolated from Eupatorium cannabinum Linn. Apoptosis ferroptosis detected in vitro vivo . RNA knockdown used investigate role p53 apoptosis Eup-induced cell death. A xenograft animal model...
The pathogenesis of Graves' disease (GD) remains unclear. In terms environmental factors, GD development may be associated with chronic inflammation caused by alteration the intestinal flora. This study explored association flora among Han population in southwest China.Fifteen patients at Affiliated Hospital Zunyi Medical College between March 2016 and 2017 were randomly enrolled. Additionally, 15 sex- age-matched healthy volunteers selected as control group during same period. Fresh stool...
Immune dysfunction caused by environmental factors plays an important role in the development of Graves’ disease (GD), and are closely related to intestinal flora. Our previous study showed significant changes flora GD patients compared with healthy volunteers. This analyzed relationships between flora, thyroid function relevant antibodies before after methimazole treatment. The subjects were divided into UGD group (18 newly diagnosed patients), TGD (10 normal or approximately treatment) NC...
Valtrate is a principle compound isolated from Valeriana jatamansi Jones, traditional Chinese folk medicine originally used to treat various nervous disorders. Here, we found that valtrate exhibited significant anti-cancer activity in vitro, especially human breast cancer cells, while displayed relatively low cytotoxicity normal epithelial cells (MCF 10A). induced cell cycle arrest at G2/M stage and apoptosis MDA-MB-231 MCF-7 with reduced expression of p-Akt (Ser 473), cyclin B1 caspase 8,...
Isoalantolactone is one of the major active ingredients from Inula helenium L. However, it low cost-effective to isolate isoalantolactone In this study, we optimized extraction strategy and obtained a mixture with exact proportion (termed as F35), which were alloalantolactone, alantolactone at ratio 1/5/4 respectively. The anti-tumor activity F35 was compared on pancreatic cancer cells. As result, showed nearly same anti-proliferation in two cell lines. Both could induce...
Eupalinolide J (EJ) is an active component from Eupatorium lindleyanum DC. (EL), which was reported to have good antitumor activity via STAT3 and Akt signaling pathways. In this study, we identified as a potential anti-cancer metastatic agent by target prediction molecular docking technique screening. Follow-up experiments demonstrated that EJ exhibited inhibitory effect on cancer cell metastasis both in vitro vivo, could effectively reduce the expression of STAT3, MMP-2, MMP-9 proteins...
Caudatin 3-O-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-D-cymaropyranosyl-(<mml:math id="M2"><mml:mn>1</mml:mn><mml:mo>→</mml:mo><mml:mn>4</mml:mn></mml:math>)-<mml:math id="M3"><mml:mrow><mml:mi>β</mml:mi></mml:mrow></mml:math>-D-oleandropyranosyl-(<mml:math id="M4"><mml:mn>1</mml:mn><mml:mo>→</mml:mo><mml:mn>4</mml:mn></mml:math>)-<mml:math...
BACKGROUND:Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as endogenous TLR4 ligand. Ligand activation activates nuclear factor-kappaB (NF-κB) and the transcription NF-κB-regulated inflammatory cytokines, which are involved in development atherosclerosis. MMP9 a member MMP family can affect plaque stability. However, mechanism responsible for effect LPA on expression has not been fully elucidated. In present study we examined activity THP-1...
Persistent activation of STAT3 plays an important role in the development triple-negative breast cancer (TNBC) and suppression is considered as a novel approach for therapy. In this project, we aimed to examine anticancer activity molecular mechanism Eupalinolide J (EJ) TNBC cells. The presented results demonstrated that growth human cells (MDA-MB-231 MDA-MB-468 cells) was obviously inhibited by EJ. IC50 values were 3.74 ± 0.58 4.30 0.39 μM, respectively. Further study EJ suppressed...