A5103262827- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Protease and Inhibitor Mechanisms
- Transplantation: Methods and Outcomes
- Vitamin D Research Studies
- Aortic aneurysm repair treatments
- Bone Metabolism and Diseases
- Aquaculture disease management and microbiota
- Adenosine and Purinergic Signaling
- Histone Deacetylase Inhibitors Research
- Aquaculture Nutrition and Growth
- Fibroblast Growth Factor Research
- Salivary Gland Tumors Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
- Cancer Research and Treatments
- Cardiac Ischemia and Reperfusion
- Gastric Cancer Management and Outcomes
- Physiological and biochemical adaptations
- Bone health and treatments
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
General Hospital of Shenyang Military Region
2020-2025
Nanchang University
2023-2024
Shanghai Changzheng Hospital
2020-2024
Second Affiliated Hospital of Nanchang University
2024
Chinese Academy of Fishery Sciences
2023-2024
Laoshan Laboratory
2023
Qingdao National Laboratory for Marine Science and Technology
2023
First Affiliated Hospital of Zhengzhou University
2022
Second Military Medical University
2006-2020
Hainan Branch of People's Liberation Army General Hospital
2019
Osteoarthritis (OA), the most prevalent age-related joint disorder, is characterized by chronic inflammation, progressive articular cartilage destruction, and subchondral bone sclerosis. Accumulating evidences indicate that circular RNAs (circRNAs) play a critical role in various diseases, but function of circRNAs OA remains largely unknown. Here we showed circRNA.33186 was significantly upregulated IL-1β)-treated chondrocytes tissues destabilized medial meniscus (DMM)-induced mouse model....
Circular RNAs (circRNAs) represent a class of non-coding that are involved in transcriptional and posttranscriptional gene expression regulation associated with different kinds human diseases. However, the characterization function circular peripheral nerve injuries remain elusive. Here, we established rat sciatic injury model identified at least 4,942 distinct RNA candidates series were differentially expressed injured tissues compared matched normal tissues. We characterized one frequently...
Osteoarthritis (OA) is the most common arthritis that characterized by progressive synovial inflammation and loss of articular cartilage. Although GYY4137 a novel slow-releasing hydrogen sulfide (H2S) donor with potent anti-inflammatory properties may modulate progression OA, its underlying mechanism remains unclear. In this study, we validated protective role against OA pathological courses elucidated regulatory mechanisms. Cell transfection, immunofluorescence staining, EdU assay,...
Abstract Objective Osteoporosis is a global health issue characterized by decreased bone mass and microstructural degradation, leading to an increased risk of fractures. This study aims explore the molecular mechanism which P2X7 receptors influence osteoclast formation resorption through PI3K-Akt-GSK3β signaling pathway. Methods An osteoporosis mouse model was generated ovariectomy (OVX) in normal C57BL/6 f/f ; LysM-cre mice. Osteoclasts were isolated for transcriptomic analysis,...
The mitochondrial unfolded protein response (UPRmt) is a mitochondrial-to-nuclear signaling pathway that activated to maintain function when there an accumulation of misfolded proteins within mitochondria. Mitochondrial essential for chondrocyte homeostasis, and dysfunction characteristic osteoarthritis (OA). However, the role UPRmt in OA remains unclear. In present study, level was examined primary mouse chondrocytes subjected different stresses articular cartilage model mice patients....
Circular RNAs (circRNAs) are involved in a variety of human diseases; however, the function circRNAs osteoarthritis (OA) remains largely unknown. In this study, we investigated role CircCDH13 OA and its underlying mechanisms. CircRNA expression profiles normal cartilage tissues were detected by microarray. The pattern, functional role, mechanisms studied vitro vivo. Gain-of-function loss-of-function approaches used to demonstrate participation OA. regulatory relationship between miR-296-3p...
Recent studies indicate that circular ribonucleic acids (circRNAs) are involved in a variety of human diseases. The roles circRNAs traumatic spinal cord injury (SCI) remain unknown, however. We performed RNA-seq to analyze the circRNA expression profile rat after SCI and investigate relevant mechanisms. In all, 150 were significantly differentially expressed by fold-change ≥2 p value ≤0.05. Among these, 99 upregulated, while 51 downregulated. Gene ontology, Kyoto Encyclopedia Genes Genomes...
Purpose: The aim of this study was to generate a novel miRNA expression signature effectively assess nodal metastasis, distant metastasis and predict prognosis for patients with kidney renal clear cell carcinoma (KIRC) explore its potential mechanism affecting the prognosis. Method: Using profiles downloaded from Cancer Genome Atlas database, we identified multiple miRNAs differential between KIRC paired normal tissues. diagnostic values differentially expressed were evaluated by Receiver...
Triple-negative breast cancer (TNBC) is the most aggressive subtype of cancer, characterized by advanced disease stage and poor prognosis. Moreover, due to lack therapeutic markers, TNBC patients can't benefit fully from currently available targeted therapies.To understand molecular basis TNBC, we used gene set enrichment analysis (GSEA) screen out altered functional module in publicly microarray data studied association candidate with development.We found that proteasome was significantly...
Abstract Objectives Calcium ion signals are important for osteoclast differentiation. Transient receptor potential vanilloid 6 (TRPV6) is a regulator of bone homeostasis. However, it was unclear whether TRPV6 involved in formation. Therefore, the aim this study to evaluate role TPRV6 metabolism and clarify its regulatory osteoclasts at cellular level. Materials methods Bone structure histological changes Trpv6 knockout mice were examined using micro‐computed tomography analyses. To...
BACKGROUND:Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as endogenous TLR4 ligand. Ligand activation activates nuclear factor-kappaB (NF-κB) and the transcription NF-κB-regulated inflammatory cytokines, which are involved in development atherosclerosis. MMP9 a member MMP family can affect plaque stability. However, mechanism responsible for effect LPA on expression has not been fully elucidated. In present study we examined activity THP-1...
MicroRNAs (miRNAs) play an essential role in the chondrogenesis and progression of osteoarthritis (OA). This study aimed to determine miRNAs associated with human mesenchymal stem cells (hMSCs) chondrocyte metabolism. MiRNAs were screened hMSCs during by RNA-seq qRT-PCR. MiRNA expression was determined primary chondrocytes (PHCs), degraded cartilage samples. mimics inhibitors transfected effect miRNA. Bioinformatic analysis luciferase reporter assays applied target gene The results...
Background Formation and rupture of abdominal aortic aneurysm (AAA) is fatal, the pathological processes molecular mechanisms underlying its formation development are unclear. Perivascular adipose tissue (PVAT) has attracted extensive attention as a newly defined secretory organ, we aim to explore potential association between PVAT AAA. Methods We analyzed gene expression clinical data 30 around AAA normal aorta (NAA). The diagnostic markers immune cell infiltration were further investigated...