A5087705543- Spine and Intervertebral Disc Pathology
- Cervical and Thoracic Myelopathy
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Connective tissue disorders research
- Bone Tissue Engineering Materials
- TGF-β signaling in diseases
- Bone health and osteoporosis research
- Spinal Hematomas and Complications
- Bone Metabolism and Diseases
- Anesthesia and Pain Management
- Medical Imaging and Analysis
- Sleep and related disorders
- Vitamin K Research Studies
- Graphene and Nanomaterials Applications
- Pain Mechanisms and Treatments
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Proteoglycans and glycosaminoglycans research
- Scoliosis diagnosis and treatment
- Antimicrobial agents and applications
- Bone fractures and treatments
- Circular RNAs in diseases
- Heterotopic Ossification and Related Conditions
- Osteoarthritis Treatment and Mechanisms
Shanghai Changzheng Hospital
2014-2025
Second Military Medical University
2015-2025
Wenzhou Medical University
2024-2025
United States Department of the Navy
2025
Tongren Hospital
2022
Shanghai Jiao Tong University
2022
National Natural Science Foundation of China
2020
Rush University Medical Center
2017
Northwestern University
2009
In the current global crisis of antibiotic resistance, delivery systems are emerging to combat resistant bacteria in a more efficient manner. Despite significant advances nanocarriers, many challenges like poor biocompatibility, premature drug release, suboptimal targeting infection sites and short blood circulation time still challenging. To achieve targeted enhance antibacterial activity, here we reported kind pH-responsive nanoparticles by simply self-assembly an amphiphilic poly(ethylene...
We study distributed algorithms for updating transmit preceding matrices a two-user Multi-Input/Multi-Output (MIMO) interference channel. Our objective is to maximize the sum rate with linear Minimum Mean Squared Error (MMSE) receivers, treating as additive Gaussian noise. An iterative approach considered in which given set of and powers, each receiver announces an price (marginal decrease due increase interference) received beam, corresponding column precoding matrix. Given prices from...
The inhibition of osteoblast proliferation by glucocorticoids (GCs) is very important in the etiology GC-induced osteoporosis. mechanisms this process are still not fully understood. results recent studies have indicated an role for microRNAs GC-mediated responses various cellular processes, including cell and apoptosis. Therefore, we developed hypothesis that these regulatory molecules might be involved GC-decreased proliferation. Western blotting, quantitative real-time PCR, assays,...
Ossification of the posterior longitudinal ligament (OPLL) is a genetic disorder which involves pathological heterotopic ossification spinal ligaments. Although studies have identified several genes that correlated with OPLL, underlying regulation network far from clear. Through small RNA sequencing, we compared microRNA expressions primary cells form OPLL patients normal (PLL) and 218 dysregulated miRNAs (FDR < 0.01). Furthermore, assessing miRNA profiling data multiple cell types, found...
Discogenic low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there no in vivo mouse models of DLBP, which restricts research this field. The aim study was establish a reliable DLBP model that captures the pathological changes disc allows longitudinal testing. generated by puncturing lumbar discs (L4/5, L5/6, L6/S1) removing nucleus pulposus using microscalpel under microscope. Histology, molecular pathways,...
Abstract Intervertebral disc degeneration (IDD) is characterized by disordered extracellular matrix (ECM) metabolism, implicating subdued anabolism and enhanced catabolic activities in the nucleus pulposus (NP) of discs. Pro-inflammatory cytokines such as interleukin-1β (IL-1β) are considered to be potent mediators ECM breakdown. Hemeoxygenase-1 (HO-1) has been reported participate cellular anti-inflammatory processes. The purpose this study was investigate HO-1 modulation metabolism human...
In contrast to the early acting bone morphogenetic protein 2, 7 (BMP7) plays a decisive role mainly in late stages of formation. To overcome deactivation and degradation expensive BMP7, we designed novel long-acting BMP7 release system based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) nanoparticles enable induction osteogenic differentiation human adipose mesenchymal stem cells (ADSCs). order improve encapsulation efficiency avoid damage by organic solvents, was modified...
Study Design. A retrospective study. Objective. To assess the long-term results of zero-profile spacer for 3-level anterior cervical discectomy and fusion (ACDF). Summary Background Data. Although widely used, there are still controversies about spacer, especially in multilevel cases. Methods. Cases received ACDF spondylotic myelopathy (CSM) using either (n = 27) (ZP Group), or plate cages 34) (PC with 5-year follow-up were reviewed. Neurological function life quality assessed by modified...
ABSTRACT The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the sulfate backbone required for synthesis sulfated glycosaminoglycan (sGAG). Transforming growth beta (TGF‐β) upregulates sGAG nucleus pulposus cells; however, mechanisms mediating this induction are incompletely understood. Our study demonstrated that ChPF expression was negatively correlated with grade degenerative intervertebral disc disease. Treatment cells TGF‐β induced and enhanced...
// Bo Hu 1, * , Chen Xu Ye Tian Changgui Shi 1 Ying Zhang Lianfu Deng 2 Hongyu Zhou Peng Cao Huajiang and Wen Yuan Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China Shanghai Key Laboratory for Bone Joint Diseases, Institute Orthopaedics Traumatology, Ruijin Jiao Tong University School Medicine, These authors contributed equally to this work Correspondence to: Chen, email: spine.chen@163.com Yuan, yuanwenspine@126.com Cao,...
Continuous efforts on pursuit of effective drug delivery systems for engineering hydrogel scaffolds is considered a promising strategy the bone-related diseases. Here, we developed kind acetylsalicylic acid (aspirin, ASA)–based double-network (DN) containing positively charged natural chitosan (CS) and methacrylated gelatin (GelMA) polymers. Combination physical chain-entanglement, electrostatic interactions, chemically cross-linked network led to formation DN hydrogel, which had suitable...
Astragaloside (AS) has an anti-osteoporotic effect, but its poor water solubility and low bioavailability limit application. In this study, a novel nano-carrier with bone targeting was prepared by modifying mPEG-PLGA alendronate (AL) before incorporation into astragaloside nano-micelles (AS-AL-mPEG-PLGA) to enhance the oral bioavailability, anti-osteoporosis effect of AS. The release behavior AS-AL-mPEG-PLGA in vitro investigated via dialysis. pharmacokinetics studied Sprague-Dawley (SD)...