A5101652463- Circular RNAs in diseases
- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Plant Molecular Biology Research
- Plant Gene Expression Analysis
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Plant nutrient uptake and metabolism
- Plant Micronutrient Interactions and Effects
- Drug Transport and Resistance Mechanisms
- DNA Repair Mechanisms
- Photosynthetic Processes and Mechanisms
- Animal Virus Infections Studies
- Plant Stress Responses and Tolerance
- Bone health and treatments
- Fibroblast Growth Factor Research
- BRCA gene mutations in cancer
- Plant Physiology and Cultivation Studies
- Pharmacogenetics and Drug Metabolism
- Horticultural and Viticultural Research
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- IL-33, ST2, and ILC Pathways
- Epigenetics and DNA Methylation
Hebei Medical University
2019-2025
Shandong Agricultural University
2018-2024
First Hospital of China Medical University
2011-2024
China Medical University
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Northwest A&F University
2020-2022
Xi'an Medical University
2022
Sichuan University
2022
West China Hospital of Sichuan University
2022
Huashan Hospital
2020
As the human life span increases, number of people suffering from cognitive decline is rising dramatically. The mechanisms underlying age-associated memory impairment are, however, not understood. Here we show that disturbances in aging brain mouse are associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation histone H4 lysine 12 (H4K12) acetylation and fail to initiate gene expression program consolidation. Restoration physiological...
Sugars increase with drought stress in plants and accumulate the vacuole. However, exact molecular mechanism underlying this process is not clear yet. In study, protein interaction phosphorylation experiments were conducted for sucrose transporter CIPK kinase apple. The specific site of was identified mass spectrometry. Transgenic analyses performed to characterize their biological function. It found that overexpression gene MdSUT2.2 apple promoted sugar accumulation tolerance....
Abstract Soil salinity is one of the major abiotic stressors that negatively affect crop growth and yield. Salt stress can regulate antioxidants accumulation osmoprotectants. In study, a sucrose transporter MdSUT2.2 was identified in apple. Overexpression gene increased salt tolerance transgenic apple, compared with WT control “Gala.” addition, it found protein phosphorylated at Ser 254 site response to salt. A DUAL membrane yeast hybridization system through an apple cDNA library...
Hypoxia-inducible factor 1-α (HIF-1α) plays a critical role in angiogenesis-osteogenesis coupling during bone development and regeneration. Previous studies have shown that 17β-estradiol activates the HIF-1α signaling pathway mice with conditional activation of osteoblasts are protected from ovariectomy (OVX)-induced loss. In addition, it has been hypoxia facilitates osteogenic differentiation mesenchymal stem cells (MSCs) modulates Wnt/β-catenin signaling. Therefore, we hypothesized by...
The regeneration capacity of osteoporotic bones is generally lower than that normal bones. Current methods bone defect treatment are not always satisfactory. Recent studies demonstrate activation the hypoxia inducible factor-1α (HIF-1α) pathway, by genetic or hypoxia-mimicking agents, could accelerate regeneration. However, little known as to whether modulating HIF-1α pathway promotes healing. To address this problem in present study, we first demonstrated and vascular endothelial growth...
Sugars are important energy source and signaling molecule in plant, sugar transporters such as SWEET (sugars will eventually be exported transporters) play roles plant growth development well biotic abiotic stresses. In this study, a gene named MdSWEET17 was isolated from apple (Malus×domestic). Expression analysis suggested that expressed all tested tissues (root, stem, leaf, flower fruit) the transcript levels were different. Furthermore, transgenic tomatoes wild type treated with drought....
Abstract The ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) plays a central role in light-induced anthocyanin biosynthesis. However, the upstream regulatory factors of COP1 remain poorly understood, particularly horticultural plants. Here, we identified an MdCOP1-interacting protein, BROAD-COMPLEX, TRAMTRACK AND BRIC A BRAC2 (MdBT2), apple (Malus domestica). MdBT2 is BTB protein that directly interacts with and stabilizes MdCOP1 by inhibiting self-ubiquitination. Fluorescence...
It is known that type 1 diabetes (T1D) reduces bone mass and increases the risk for fragility fractures, an effect has been largely ascribed to decreased formation. However, potential role of angiogenesis as a factor in osteogenesis reduction not extensively studied. Furthermore, there controversy surrounding T1D on resorption. This study characterized microstructure, strength, turnover streptozotocin (STZ)-induced diabetic mice (T1D mice) explored pathogenesis T1D-induced osteoporosis....
The inhibition of osteoblast proliferation by glucocorticoids (GCs) is very important in the etiology GC-induced osteoporosis. mechanisms this process are still not fully understood. results recent studies have indicated an role for microRNAs GC-mediated responses various cellular processes, including cell and apoptosis. Therefore, we developed hypothesis that these regulatory molecules might be involved GC-decreased proliferation. Western blotting, quantitative real-time PCR, assays,...
Abstract Xeroderma pigmentosum complementation group C and G ( XPC , XPG ) play important roles in DNA damage repairing machinery. Genetic variations the may be associated with increased risk for colorectal carcinoma (CRC). In this study, we evaluated relation between Lys939Gln, Asp1104His polymorphisms, CRC susceptibility a population‐based case–control which included 1,028 cases 1,085 controls. Compared corresponding wild genotypes, found that individuals at least one copy of Lys939Gln (AC...
Functional cross-talk between osteoblasts and osteoclasts is a key process for bone homeostasis. Although osteoblast hypoxia inducible factor-1α (HIF-1α) pathway activation results in impaired osteoclastogenesis via the direct regulation of osteoprotegerin (OPG), it unclear whether there are other efficient mediators involved HIF-1α activation-restrained osteoclast formation. In addition to upregulated OPG, we observed that led increased interleukin-33 (IL-33) expression, which was found...
Phthalates （PAEs） are widely employed as plasticizers in plastic products that used industrial， agricultural， food， medical， and other fields. PAEs relatively weakly bonded to through non-covalent interactions. Consequently， can easily leak from the product into environment， which exposes public food intake， skin absorption personal care products， by inhaling air. Related studies have shown endocrine-disrupting substances long-term exposure may result diseases of nervous， reproductive，...
The hypoxia-inducible factors (HIFα) are the critical that couple angiogenesis and osteogenesis by activating transcription of VEGF in osteoblasts. Mice lacking von Hippel–Lindau gene (Vhl), thus overexpressing HIFα osteoblasts develop extremely dense highly vascularized long bones. Here we provide evidence Vhl overexpress secrete high levels VEGF, which subsequently promotes proliferation osteogenic differentiation bone marrow stromal cells (BMSC) promoting expression Heme oxygenase-1...
The genetic variants of the ATP-binding cassette, subfamily G, member 2 ( ABCG2 ) are known to be involved in developing cancer risk and interindividual differences chemotherapeutic response. polymorphisms gene were genotyped by using PCR-RFLP assays. We found that G34A GA/AA genotype, C421A AA haplotypes 34A-421C 34G-421A significantly associated with increased for breast carcinoma. Furthermore, homozygote had a significant enhanced therapeutic response patients neoadjuvant...
Abstract Pattern recognition receptors (PRRs), including Toll-like receptor 3 (TLR3), are involved in arthritic responses; however, whether interleukin-33 (IL-33) is TLR3-mediated cartilage degeneration unknown. Here, we found that IL-33 was abundantly increased chondrocytes of osteoarthritis, especially the weight-bearing cartilage. Furthermore, double-stranded RNA (dsRNA) released from damaged articular induced by mechanical stretching upregulated expression to a greater degree than IL-1 β...
Heavy metal contamination is a major environmental and human health hazard in many areas of the world. Organic acids sequester heavy metals protect plant roots from effects toxicity; however, it largely unknown how these are regulated response to stress. Here, protein kinase SOS2L1 apple was functionally characterized. MdSOS2L1 found be involved regulation malate excretion, inhibit cadmium uptake into roots. Using DUAL membrane system screen an cDNA library with as bait, transporter,...
Aim: To evaluate the association of ABCB1 gene polymorphisms with susceptibility to colorectal cancer (CRC) and clinical outcomes CRC patients chemotherapy. Patients & methods: A case–control study was performed on C3435T, C1236T G2677T/A in 1028 1230 controls. Results: We observed that C3435T variants as well 3435T–1236T–2677T haplotype significantly increased risk CRC. The CT genotype had a significant effect time recurrence (adjusted hazard ratio [HR; 95% CI]: 0.560 [0.355–0.882]; p =...