A5100741518- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Genetic Associations and Epidemiology
- Head and Neck Cancer Studies
- Nutritional Studies and Diet
- Estrogen and related hormone effects
- Evolutionary Game Theory and Cooperation
- Endometrial and Cervical Cancer Treatments
- Cancer Genomics and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glutathione Transferases and Polymorphisms
- Lung Cancer Research Studies
- Evolution and Genetic Dynamics
- Air Quality and Health Impacts
- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Folate and B Vitamins Research
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Mathematical and Theoretical Epidemiology and Ecology Models
- MicroRNA in disease regulation
Fred Hutch Cancer Center
2016-2025
University of Washington
2016-2025
Children's Hospital of Fudan University
2015-2025
University of Science and Technology of China
2025
Women's Health Initiative
2022-2025
Hebei Medical University
2018-2025
Second Affiliated Hospital of Nantong University
2018-2024
Nantong University
2011-2024
Affiliated Hospital of Nantong University
2011-2024
Qingdao University
2020-2024
Abstract Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on head neck cancers is not clear because studies have used various methods to quantify excess cancer burden. Methods: We analyzed individual-level pooled data from 17 European American case-control (11,221 cases 16,168 controls) participating in International Head Neck Cancer Epidemiology consortium. estimated multiplicative parameter (ψ) population attributable risks (PAR). Results: A...
Although the Women's Health Initiative (WHI) trial of estrogen plus progestin in postmenopausal women identified more overall health risks than benefits among hormone group, use was associated with a significant decrease risk colorectal cancer. We analyzed features cancers that developed and their relation to characteristics participants.
Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
To determine the association between use of vaginal estrogen and risk a global index event (GIE), defined as time to first occurrence coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal endometrial or death from any cause.
Population demand, healthcare resourcing, and transportation linkage are considered as major determinants of spatial access to health care. Temporal changes the 3 would result in gain or loss As a remarkable milestone achieved by Targeted Poverty Reduction Project launched China, significant improvements care served an ideal context for investigating relative contributions these rural county. A national level poverty-stricken county, Chishui county from Guizhou province, was chosen our study...
Abstract Objective: Levels of estrogen, androgen, and prolactin have been related to risk postmenopausal breast cancer. However, the determinants these hormone concentrations are not established. The purpose this study was examine correlates endogenous sex hormones. Research Methods Procedures: Associations among adiposity, physical activity, diet estradiol, free estrone, testosterone, hormone‐binding globulin (SHBG), androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate,...
Abstract Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared gene expressions incident primary oral dysplasia, clinically normal tissue from surgical patients without head neck cancer or preneoplastic lesions (controls), using Affymetrix U133 2.0 Plus arrays. We identified 131 differentially expressed probe sets a training set 119 OSCC 35 controls. Forward stepwise...