Chu Chen

ORCID: 0000-0003-2267-8050
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About
Contact & Profiles
Research Areas
  • RNA modifications and cancer
  • Cancer-related molecular mechanisms research
  • Cancer Risks and Factors
  • Epigenetics and DNA Methylation
  • Lung Cancer Treatments and Mutations
  • Genetic Associations and Epidemiology
  • Head and Neck Cancer Studies
  • Nutritional Studies and Diet
  • Estrogen and related hormone effects
  • Evolutionary Game Theory and Cooperation
  • Endometrial and Cervical Cancer Treatments
  • Cancer Genomics and Diagnostics
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Glutathione Transferases and Polymorphisms
  • Lung Cancer Research Studies
  • Evolution and Genetic Dynamics
  • Air Quality and Health Impacts
  • BRCA gene mutations in cancer
  • Ferroptosis and cancer prognosis
  • Cancer-related gene regulation
  • Folate and B Vitamins Research
  • Genetic factors in colorectal cancer
  • Radiomics and Machine Learning in Medical Imaging
  • Mathematical and Theoretical Epidemiology and Ecology Models
  • MicroRNA in disease regulation

Fred Hutch Cancer Center
2016-2025

University of Washington
2016-2025

Children's Hospital of Fudan University
2015-2025

University of Science and Technology of China
2025

Women's Health Initiative
2022-2025

Hebei Medical University
2018-2025

Second Affiliated Hospital of Nantong University
2018-2024

Nantong University
2011-2024

Affiliated Hospital of Nantong University
2011-2024

Qingdao University
2020-2024

Abstract Background: The magnitude of risk conferred by the interaction between tobacco and alcohol use on head neck cancers is not clear because studies have used various methods to quantify excess cancer burden. Methods: We analyzed individual-level pooled data from 17 European American case-control (11,221 cases 16,168 controls) participating in International Head Neck Cancer Epidemiology consortium. estimated multiplicative parameter (ψ) population attributable risks (PAR). Results: A...

10.1158/1055-9965.epi-08-0347 article EN Cancer Epidemiology Biomarkers & Prevention 2009-02-01

Although the Women's Health Initiative (WHI) trial of estrogen plus progestin in postmenopausal women identified more overall health risks than benefits among hormone group, use was associated with a significant decrease risk colorectal cancer. We analyzed features cancers that developed and their relation to characteristics participants.

10.1056/nejmoa032071 article EN New England Journal of Medicine 2004-03-03

Background Assessing the relationship between lung cancer and metabolic conditions is challenging because of confounding effect tobacco. Mendelian randomization (MR), or use genetic instrumental variables to assess causality, may help identify drivers cancer. Methods findings We identified instruments for potential risk factors evaluated these in relation using 29,266 cases (including 11,273 adenocarcinomas, 7,426 squamous cell 2,664 small cases) 56,450 controls. The MR analysis suggested a...

10.1371/journal.pone.0177875 article EN public-domain PLoS ONE 2017-06-08

10.1038/ng.3002 article EN Nature Genetics 2014-06-01
James McKay Thérèse Truong Valérie Gaborieau Amélie Chabrier Shu-Chun Chuang and 95 more Graham Byrnes Давид Заридзе Oxana Shangina Neonila Szeszenia‐Dąbrowska Jolanta Lissowska Péter Rudnai Eleonóra Fabiánová Alexandru Bucur Vladimír Bencko Ivana Holcátová Vladimí­r Janout Lenka Foretová Παγώνα Λάγιου Dimitrios Trichopoulos Simone Benhamou Christine Bouchardy Wolfgang Ahrens Franco Merletti Lorenzo Richiardi Renato Talamini Luigi Barzan Kristina Kjærheim Gary J. Macfarlane Tatiana V. Macfarlane Lorenzo Simonato Cristina Canova Antonio Agudo Xavier Castellsagué Ray Lowry David I. Conway Patricia A. McKinney Claire M. Healy Mary Toner Ariana Znaor María Paula Curado Sérgio Koifman Ana Menezes Victor Wünsch‐Filho José Eluf‐Neto Letícia Fernández Garrote Stefania Boccia Gabriella Cadoni Dario Arzani Andrew F. Olshan Mark C. Weissler William K. Funkhouser Jingchun Luo Jan Lubiński Joanna Trubicka Marcin Lener Dorota Oszutowska–Mazurek Stephen M. Schwartz Chu Chen Sherianne Fish David R. Doody Joshua Muscat Philip Lazarus Carla J. Gallagher Shen-Chih Chang Zuo‐Feng Zhang Qingyi Wei Erich M. Sturgis Li‐E Wang Silvia Franceschi Rolando Herrero Karl T. Kelsey Michael D. McClean Carmen J. Marsit Heather H. Nelson Marjorie Romkes Shama Buch Tomoko Nukui Shilong Zhong Martin Lacko Johannes J. Manni Wilbert H.M. Peters Rayjean J. Hung Esther M. John Lars J. Vatten Inger Njølstad Gary E. Goodman John K. Field Triantafillos Liloglou Paolo Vineis Françoise Clavel‐Chapelon Domenico Palli ­Rosario ­Tumino Vittorio Krogh Salvatore Panico Carlos A. González J. Ramón Quirós Carmen Martı́nez Carmen Navarro Eva Ardanáz Nerea Larrañaga

Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved susceptibility to etiologically complex disease. We conducted a GWAS identify upper aero-digestive tract (UADT) cancers. genotyping was carried out using the Illumina HumanHap300 beadchips 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre studies, as well 4,821 generic controls. The 19 top-ranked variants were investigated further an additional 6,514...

10.1371/journal.pgen.1001333 article EN cc-by PLoS Genetics 2011-03-17
Tracy A. O’Mara Dylan M. Glubb Frédéric Amant Daniela Annibali Katie A. Ashton and 95 more John Attia Paul L. Auer Matthias W. Beckmann Amanda Black Manjeet K. Bolla Hiltrud Brauch Hermann Brenner Louise A. Brinton Daniel D. Buchanan Barbara Burwinkel Jenny Chang‐Claude Stephen J. Chanock Chu Chen Maxine Chen Timothy Cheng Christine L. Clarke Mark Clendenning Linda S. Cook Fergus J. Couch Angela Cox Marta Crous‐Bou Kamila Czene Felix R. Day Joe Dennis Jeroen Depreeuw Jennifer A. Doherty Thilo Dörk Sean C. Dowdy Matthias Dürst Arif B. Ekici Peter A. Fasching Brooke L. Fridley Christine M. Friedenreich Lin Fritschi Jenny N. Fung Montserrat García‐Closas Mia M. Gaudet Graham G. Giles Ellen L. Goode Maggie Gorman Christopher A. Haiman Per Hall Susan E. Hankison Catherine S. Healey Alexander Hein Peter Hillemanns Shirley Hodgson Erling A. Høivik Elizabeth Holliday John L. Hopper David J. Hunter Angela Jones Camilla Krakstad Vessela N. Kristensen Diether Lambrechts Loı̈c Le Marchand Xiaolin Liang Annika Lindblom Jolanta Lissowska Jirong Long Lingeng Lu Anthony M. Magliocco Lynn Martin Mark McEvoy Alfons Meindl Kyriaki Michailidou Roger L. Milne Miriam Mints Grant W. Montgomery Rami Nassir Håkan Olsson Irene Orlow Geoffrey Otton Claire Palles John R. B. Perry Julian Peto Loreall Pooler Jennifer Prescott Tony Proietto Timothy R. Rebbeck Harvey A. Risch Peter A. W. Rogers Matthias Rübner Ingo B. Runnebaum Carlotta Sacerdote Gloria E. Sarto Fredrick R. Schumacher Rodney J. Scott Veronica Wendy Setiawan Mitul Shah Xin Sheng Xiao‐Ou Shu Melissa C. Southey Anthony J. Swerdlow Emma Tham

Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...

10.1038/s41467-018-05427-7 article EN cc-by Nature Communications 2018-08-03

To determine the association between use of vaginal estrogen and risk a global index event (GIE), defined as time to first occurrence coronary heart disease (CHD), invasive breast cancer, stroke, pulmonary embolism, hip fracture, colorectal endometrial or death from any cause.

10.1097/gme.0000000000000956 article EN Menopause The Journal of The North American Menopause Society 2017-08-16

Population demand, healthcare resourcing, and transportation linkage are considered as major determinants of spatial access to health care. Temporal changes the 3 would result in gain or loss As a remarkable milestone achieved by Targeted Poverty Reduction Project launched China, significant improvements care served an ideal context for investigating relative contributions these rural county. A national level poverty-stricken county, Chishui county from Guizhou province, was chosen our study...

10.1177/00469580221146041 article EN cc-by-nc INQUIRY The Journal of Health Care Organization Provision and Financing 2023-01-01

Abstract Objective: Levels of estrogen, androgen, and prolactin have been related to risk postmenopausal breast cancer. However, the determinants these hormone concentrations are not established. The purpose this study was examine correlates endogenous sex hormones. Research Methods Procedures: Associations among adiposity, physical activity, diet estradiol, free estrone, testosterone, hormone‐binding globulin (SHBG), androstenedione, dehydroepiandrosterone, dehydroepiandrosterone sulfate,...

10.1038/oby.2006.191 article EN Obesity 2006-09-01

Abstract Oral squamous cell carcinoma (OSCC) is associated with substantial mortality and morbidity. To identify potential biomarkers for the early detection of invasive OSCC, we compared gene expressions incident primary oral dysplasia, clinically normal tissue from surgical patients without head neck cancer or preneoplastic lesions (controls), using Affymetrix U133 2.0 Plus arrays. We identified 131 differentially expressed probe sets a training set 119 OSCC 35 controls. Forward stepwise...

10.1158/1055-9965.epi-07-2893 article EN Cancer Epidemiology Biomarkers & Prevention 2008-08-01
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