A5066146057- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Uterine Myomas and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Endometriosis Research and Treatment
- Enhanced Recovery After Surgery
- Anesthesia and Pain Management
- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
- Clinical practice guidelines implementation
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Colorectal Cancer Surgical Treatments
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- Animal Genetics and Reproduction
- Surgical site infection prevention
- Genetic factors in colorectal cancer
- Biomedical and Engineering Education
- Estrogen and related hormone effects
- Nausea and vomiting management
- RNA modifications and cancer
- Cancer-related gene regulation
Mayo Clinic
2016-2025
WinnMed
2014-2025
Mayo Clinic in Arizona
2016-2025
Mayo Clinic in Florida
2009-2024
Community Link
2024
Women’s Health Care
2024
Hesco (United States)
2023
Check Point (Israel)
2023
S.P.E.C.I.E.S.
2023
Anna Needs Neuroblastoma Answers
2023
<h3>Background</h3> This is the first updated Enhanced Recovery After Surgery (ERAS) Society guideline presenting a consensus for optimal perioperative care in gynecologic/oncology surgery. <h3>Methods</h3> A database search of publications using Embase and PubMed was performed. Studies on each item within ERAS protocol were selected with emphasis meta-analyses, randomized controlled trials, large prospective cohort studies. These studies then reviewed graded according to Grading...
The “Guidelines for Pre- and Intra-operative Care in Gynecologic/Oncology Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations — Part I,” [1] examined the evidence surrounding care elements including preoperative medical optimization, bowel preparation, carbohydrate loading, thromboembolism prophylaxis, skin standard anesthetic protocol intraoperative fluid management. goal of this article is to critically review existing make recommendations postoperative care.
In Brief OBJECTIVE: Residual disease after initial surgery for ovarian cancer is the strongest prognostic factor survival. However, extent of surgical resection required to achieve optimal cytoreduction controversial. Our goal was estimate effect aggressive on patient METHODS: A retrospective cohort study consecutive patients with International Federation Gynecology and Obstetrics stage IIIC undergoing primary conducted between January 1, 1994, December 31, 1998. The main outcome measures...
•We provide evidence supporting pre- and intra-operative management of patients undergoing gynecologic/oncology surgery.•This guideline will help integrate knowledge into practice, align perioperative care, encourage future investigations.
Molecular classification of high-grade serous ovarian cancer (HGSOC) using transcriptional profiling has proven to be complex and difficult validate across studies. We determined gene expression profiles 174 well-annotated HGSOCs demonstrate prognostic significance the prespecified TCGA Network signatures. Furthermore, we confirm presence four HGSOC subtypes a de novo classification. Survival differed statistically significantly between (log rank, P = .006) was best for immunoreactive-like...
Edmonston vaccine strains of measles virus (MV) have shown significant antitumor activity in preclinical models ovarian cancer. We engineered MV to express the marker peptide carcinoembryonic antigen (MV-CEA virus) also permit real-time monitoring viral gene expression tumors clinical setting. Patients with Taxol and platinum-refractory recurrent cancer normal CEA levels were eligible for this phase I trial. Twenty-one patients treated MV-CEA i.p. every 4 weeks up 6 cycles at seven different...
To investigate the effects of enhanced recovery (a multimodal perioperative care enhancement protocol) in patients undergoing gynecologic surgery.Consecutive managed under an pathway and cytoreduction, surgical staging, or pelvic organ prolapse surgery between June 20, 2011, December were compared with consecutive historical controls (March to 2010) matched by procedure. Wilcoxon rank-sum, χ, Fisher's exact tests used for comparisons. Direct medical costs incurred first 30 days obtained from...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
To estimate lower extremity lymphedema prevalence in patients surgically treated for endometrial cancer, identify predictors of lymphedema, and evaluate the effects on quality life.One thousand forty-eight consecutive who were operated between 1999 2008 at Mayo Clinic mailed a survey, which included our validated 13-item screening questionnaire two quality-of-life measures. Logistic regression models fit to factors associated with prevalent lymphedema; multivariable model was obtained using...
Objective: The aim of this study was to conduct a prospective, multicenter survey patients regarding postoperative opioid use inform development standardized, evidence-based, procedure-specific prescribing guidelines. Summary Background Data: Previous work has shown significant variation in the amount opioids prescribed after elective procedures, calling for optimization prescribing. Methods: Adults (n = 3412) undergoing 25 procedures were identified prospectively from 3 academic centers...
Summary This international multidisciplinary consensus statement was developed to provide balanced guidance on the safe peri‐operative use of opioids in adults. An panel healthcare professionals evaluated literature relating postoperative opioid‐related harm, including persistent opioid use; opioid‐induced ventilatory impairment; non‐medical diversion and dependence; driving under influence prescription opioids. Recommended strategies reduce harm include pre‐operative assessment risk an...
Purpose Identify features on preoperative computed tomography (CT) scans to predict suboptimal primary cytoreduction in patients treated for advanced ovarian cancer institution A. Reciprocally cross validate the predictors identified with those from two previously published cohorts institutions B and C. Patients Methods Preoperative CT stage III/IV epithelial who underwent A between 1999 2005 were retrospectively reviewed by radiologists blinded surgical outcome. Fourteen criteria assessed....
Computed tomography (CT) scans of the abdomen and pelvis may predict which patients with ovarian carcinoma can undergo optimal cytoreduction at primary surgery. Previous studies have demonstrated that had rates ranging from 50-60%. The authors sought to determine whether these findings applied a surgical practice higher rate debulking. A predictive model using CT scanning CA 125 values would allow be more appropriately treated neoadjuvant chemotherapy.Preoperative for Stage III/IV (according...
Edmonston vaccine strains of measles virus (MV) have significant antitumor activity in mouse xenograft models ovarian cancer. MV engineered to express the sodium iodide symporter gene (MV-NIS) facilitates localization viral expression and offers a tool for tumor radiovirotherapy. Here, we report results from clinical evaluation MV-NIS patients with taxol- platinum-resistant was given intraperitoneally every 4 weeks up 6 cycles. Treatment well tolerated associated promising median overall...