Tracy A. O’Mara
A5075944195- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Estrogen and related hormone effects
- BRCA gene mutations in cancer
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Cancer Genomics and Diagnostics
- Blood Coagulation and Thrombosis Mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiovascular Disease and Adiposity
- Cancer Risks and Factors
- Endometriosis Research and Treatment
- Genomics and Chromatin Dynamics
- Molecular Biology Techniques and Applications
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
QIMR Berghofer Medical Research Institute
2016-2025
Queensland University of Technology
2008-2023
The University of Queensland
2021-2023
University of Cambridge
2015
University of Newcastle Australia
2015
John Hunter Hospital
2015
Hunter Medical Research Institute
2015
Wellcome/MRC Institute of Metabolic Science
2015
Medical Research Council
2015
Wellcome Trust
2015
The causal direction and magnitude of the association between telomere length incidence cancer non-neoplastic diseases is uncertain owing to susceptibility observational studies confounding reverse causation.
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Background:Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian randomization (MR) approach to assess whether insulinemia T2D are causally cancer.
Abstract A recent genome-wide association study found that genetic variants on chromosomes 3, 6, 7, 10, 11, 19 and X were associated with prostate cancer risk. We evaluated the most significant single-nucleotide polymorphisms (SNP) in these loci using a worldwide consortium of 13 groups (PRACTICAL). Blood DNA from 7,370 cases 5,742 male controls was analyzed by genotyping assays. Odds ratios (OR) each genotype estimated unconditional logistic regression. Six seven SNPs showed clear evidence...
Abstract Genome-wide association studies (GWAS) have led to the identification of hundreds susceptibility loci across cancers, but impact further remains uncertain. Here we analyse summary-level data from GWAS European ancestry fourteen cancer sites estimate number common variants (polygenicity) and underlying effect-size distribution. All cancers show a high degree polygenicity, involving at minimum thousands loci. We project that sample sizes required explain 80% heritability vary 60,000...
Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in development of this cancer. However, observational studies micro- macronutrients their risk have been inconsistent. Clarifying these relationships are to develop nutritional recommendations for prevention. We performed two-sample Mendelian randomization (MR) investigate effects circulating levels 15 micronutrients (vitamin A (retinol), folate, vitamin B6, B12, C, D, E,...
The causal relevance of polyunsaturated fatty acids (PUFAs) for risk site-specific cancers remains uncertain.
Abstract Summary Assessing the pathogenicity of genetic variants can be a complex and challenging task. Spliceogenic variants, which alter mRNA splicing, may yield mature transcripts that encode non-functional protein products, an important predictor Mendelian disease risk. However, most variant annotation tools do not adequately assess spliceogenicity outside native splice site thus disease-causing potential in other intronic exonic regions is often overlooked. Here, we present plugin for...
Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and estradiol (E 2 ) concentrations. We analyzed 2937 single nucleotide polymorphisms (SNPs) in 6608 cases 37 925 controls report the first genome wide-significant association between a SNP (rs727479 intron 2, P =4.8×10 −11 ). rs727479 was also among those most strongly circulating E concentrations 2767 post-menopausal ( =7.4×10 −8 The observed odds ratio per A-allele (1.15, CI=1.11–1.21) is...
Abstract Blood lipids have been associated with the development of a range cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies reported inconsistent associations between blood cancer risk. To reduce biases from unmeasured confounding, we performed bidirectional, two‐sample Mendelian randomization analysis to investigate relationship levels three (low‐density lipoprotein [LDL] high‐density [HDL] cholesterol, triglycerides) Genetic variants each...
Abstract Previous Mendelian randomization (MR) studies on 25-hydroxyvitamin D (25(OH)D) and cancer have typically adopted a handful of variants found no relationship between 25(OH)D cancer; however, issues horizontal pleiotropy cannot be reliably addressed. Using larger set associated with (74 SNPs, up from 6 previously), we perform unified MR analysis to re-evaluate the ten cancers. Our findings are broadly consistent previous indicating relationship, apart ovarian cancers (OR 0.89; 95%...
Abstract Background Adult obesity is a strong risk factor for endometrial cancer (EC); however, associations of early life with EC are inconclusive. We evaluated young adulthood (18–21 years) and (at enrolment) body mass index (BMI) weight change in the Epidemiology Endometrial Cancer Consortium (E2C2). Methods pooled data from nine case-control 11 cohort studies E2C2. performed multivariable logistic regression analyses to estimate odds ratios (OR) 95% confidence intervals (95% CI) BMI...
Abstract Background The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) quantify pairwise correlations across and identify novel susceptibility loci. Methods We collected GWAS summary statistics for solid based on 376 759 participants with 532 864 without European ancestry. included types were breast, colorectal, endometrial, esophageal, glioma, head neck, lung,...
Overweight and obesity are strongly associated with endometrial cancer. Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 MC4R rs17782313, that linked to increased body weight obesity. We examined the of rs17782313 cancer risk in a pooled analysis nine case-control within Epidemiology Endometrial Cancer Consortium (E2C2). This included 3601 non-Hispanic white women histologically-confirmed carcinoma 5275 frequency-matched...
Abstract Prostate cancer is the second most common malignancy among men worldwide. Genome-wide association studies have identified 100 risk variants for prostate cancer, which can explain approximately 33% of familial disease. We hypothesized that a comprehensive analysis genetic variations found within 3′ untranslated region genes predicted to affect miRNA binding (miRSNP) identify additional variants. investigated between 2,169 miRSNPs and in large-scale 22,301 cases 22,320 controls...
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer may be mediated via genetic or epigenetic effects on HNF1B expression. We previously found single-nucleotide polymorphisms (SNPs) at locus endometrial cancer, now report extensive fine-mapping silico laboratory analyses this locus. Analysis 1184 genotyped imputed SNPs 6608 Caucasian cases 37 925 controls, 895...