A5011535862- Cervical Cancer and HPV Research
- Endometrial and Cervical Cancer Treatments
- Global Cancer Incidence and Screening
- Genital Health and Disease
- Ovarian cancer diagnosis and treatment
- Colorectal and Anal Carcinomas
- Cancer Risks and Factors
- Uterine Myomas and Treatments
- Epigenetics and DNA Methylation
- Gynecological conditions and treatments
- Reproductive tract infections research
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Colorectal Cancer Screening and Detection
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- AI in cancer detection
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Autism Spectrum Disorder Research
- Obesity, Physical Activity, Diet
- Clinical practice guidelines implementation
- Streptococcal Infections and Treatments
National Cancer Institute
2013-2025
Division of Cancer Epidemiology and Genetics
2017-2025
Hospital for Sick Children
2014-2024
Albert Einstein College of Medicine
2012-2024
National Institutes of Health
2011-2024
McMaster University
2024
Cancer Institute (WIA)
2024
Cancer Genetics (United States)
2018-2024
University of Mississippi Medical Center
2024
Mississippi State University
2024
Uterine corpus cancer incidence rates have been projected to increase, a prediction often attributed the obesity epidemic. However, correct estimation of these requires accounting for hysterectomy prevalence, which varies by race, ethnicity, and region. Here, we evaluated recent trends in hysterectomy-corrected race ethnicity histologic subtype estimated differences relative survival subtype, stage.We prevalence from Behavioral Risk Factor Surveillance System. Hysterectomy-corrected...
Abstract The International Anal Neoplasia Society (IANS) developed consensus guidelines to inform anal cancer screening use among various high‐risk groups. incidence estimates by age risk groups provided the basis identify thresholds recommend screening. Guided thresholds, initiation at 35 years was recommended for men who have sex with (MSM) and transgender women (TW) HIV. For other people HIV MSM TW not HIV, 45 recommended. solid organ transplant recipients, beginning from 10...
Uterine cancer incidence has been increasing, particularly rates of aggressive, nonendometrioid subtypes, which are disproportionately higher among non-Hispanic Black women. The association subtype-specific trends with uterine mortality and the role tumor subtype stage at diagnosis racial disparities in deaths population-based level not known.To estimate histologic subtype- stage-specific by race ethnicity, corrected for hysterectomy.This cohort study used US Surveillance, Epidemiology, End...
We conducted an integrated population-based analysis of histologic subtype-specific cervical cancer incidence, survival, and incidence-based mortality by race ethnicity, with correction for hysterectomy prevalence.
The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for dual stain (DS) testing with CINtec PLUS Cytology use of DS to triage high-risk human papillomavirus (HPV)-positive results.
The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of extended genotyping results in cervical cancer prevention programs. Risks intraepithelial neoplasia grade 3 or worse were calculated using data obtained with Onclarity HPV Assay from large cohorts. based on clinical action thresholds 2019 American Society Colposcopy Pathology Risk-Based Guidelines. Risk estimates reviewed relation to used as basis draft...
Persistent infections with carcinogenic human papillomavirus (HPV) types are the necessary cause of cervical cancer. We recently demonstrated that HPV16 genome is strongly methylated in precancer compared transient infections. However, extent methylation other HPV and its role progression to cancer poorly understood. analyzed whole-genome patterns three next most genotypes: HPV31 (closely related HPV16), two closely types, HPV18 HPV45. DNA was extracted from cytology specimens 92 women 96...
As cervical cancer screening transitions from Papanicolaou cytologic to primary human papillomavirus (HPV) testing worldwide, effective triage tests are needed decide who among the HPV-positive women should receive further diagnostic evaluation avoid unnecessary colposcopies and biopsies.To evaluate performance of p16/Ki-67 dual stain (DS) HPV16/18 genotyping for women.A prospective observational study was conducted within program at Kaiser Permanente Northern California 3225 undergoing HPV...
Abstract Background With the advent of primary human papillomavirus testing followed by cytology for cervical cancer screening, visual interpretation slides remains last subjective analysis step and suffers from low sensitivity reproducibility. Methods We developed a cloud-based whole-slide imaging platform with deep-learning classifier p16/Ki-67 dual-stained (DS) trained on biopsy-based gold standards. compared it conventional Pap manual DS in 3 epidemiological studies anal precancers...
Vaginal pH is related to genital tract inflammation and changes in the bacterial flora, both suggested cofactors for persistence of human papillomavirus (HPV) infection. To evaluate relationship between vaginal HPV, we analyzed data from our large population-based study Guanacaste, Costa Rica. We examined risk HPV infection, cytological abnormalities, C. trachomatis Our included 9,165 women aged 18-97 at enrollment with a total 28,915 visits (mean length follow-up = 3.4 years). Generalized...
Abstract Background While behavioural abnormalities are fundamental features of Rett syndrome (RTT), few studies have examined the RTT phenotype. Most these reports focused on autistic features, linked to early regressive phase disorder, and applied standardised measures. We used a battery measures behaviour functioning test following hypotheses: (1) is prominent throughout childhood in RTT; (2) more salient individuals with milder presentation; (3) severity associated wider range problems;...
Of the ~60 human papillomavirus (HPV) genotypes that infect cervicovaginal epithelium, only 12–13 “high-risk” types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While is most important carcinogenic type, variants can differ in their carcinogenicity by 10-fold or more epidemiologic studies. Strong genotype-phenotype associations embedded small 8-kb genome motivate molecular studies to understand underlying mechanisms....
As cervical cancer screening transitions to primary human papillomavirus (HPV) testing, effective triage and management of HPV-positive women is critical avoid unnecessary colposcopy referral associated harms while maintaining high sensitivity for precancer. Triage with p16/Ki-67 dual-stain (DS) testing has shown specificity detection precancers; however, longitudinal studies are needed determine the long-term risk precancer following a negative DS result.To evaluate performance in over 5...
Purpose Obesity has been inconsistently linked to increased cervical cancer incidence and mortality; however, the effect of obesity on screening not explored. We investigated hypothesis that body mass might decrease detection precancer increase risk even in women undergoing state-of-the-art screening. Methods conducted a retrospective cohort study 944,227 age 30 64 years who underwent cytology human papillomavirus DNA testing (ie, cotesting) at Kaiser Permanente Northern California (January...
Purpose: Human papillomavirus (HPV) DNA methylation testing is a promising triage option for women HPV positive during cervical cancer screening. However, the extent to which indicates precancer all 12 carcinogenic types has not been evaluated.Experimental Design: In this nested case-control study, we tested up 30 cases of [cervical intraepithelial neoplasia grade 3 (CIN3)/adenocarcinoma in situ (AIS)] and normal controls each type (single infections with...
Objective The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of self-collected vaginal specimens human papillomavirus (HPV) testing in health care settings. Methods A comprehensive literature search was performed, external systematic reviews were evaluated, HPV genotype agreement between clinician-collected cervical summarized. Recommendations considered available data, public comments, expert consensus. ratified through...
Monogenic autoinflammatory diseases (AID) are a rapidly expanding group of genetically diverse but phenotypically overlapping systemic inflammatory disorders associated with dysregulated innate immunity. They cause significant morbidity, mortality and economic burden. Here, we aimed to develop evaluate the clinical impact NGS targeted gene panel, "Vasculitis Inflammation Panel" (VIP) for AID vasculitis.The Agilent SureDesign tool was used design 2 versions VIP; VIP1 targeting 113 genes,...