A5008978433- Colorectal and Anal Carcinomas
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Viral-associated cancers and disorders
- Anorectal Disease Treatments and Outcomes
- Gastrointestinal disorders and treatments
- Radiomics and Machine Learning in Medical Imaging
- HIV/AIDS Research and Interventions
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Neurofibromatosis and Schwannoma Cases
- Potassium and Related Disorders
- Congenital gastrointestinal and neural anomalies
- Parasitic Diseases Research and Treatment
- Immune Response and Inflammation
- Prenatal Substance Exposure Effects
- Diverticular Disease and Complications
- Parasitic infections in humans and animals
- Colorectal Cancer Screening and Detection
- Antibiotics Pharmacokinetics and Efficacy
- Spine and Intervertebral Disc Pathology
- Colorectal Cancer Surgical Treatments
- Congenital Anomalies and Fetal Surgery
- Artificial Intelligence in Healthcare and Education
- Healthcare cost, quality, practices
Wake Forest University
2011-2025
Atrium Health Wake Forest Baptist
2012-2025
New York Hospital Queens
2024
Columbia University
2024
NewYork–Presbyterian Hospital
2024
Hospital do Desterro
2016-2023
Hospital CUF Descobertas
2020-2023
University of Virginia Health System
2012
University of Virginia
2005-2009
University of South Florida
2000
The incidence of anal cancer is substantially higher among persons living with the human immunodeficiency virus (HIV) than in general population. Similar to cervical cancer, preceded by high-grade squamous intraepithelial lesions (HSILs). Treatment for HSIL reduces progression cancer; however, data from prospective studies treatment prevent are lacking.
Abstract The International Anal Neoplasia Society (IANS) developed consensus guidelines to inform anal cancer screening use among various high‐risk groups. incidence estimates by age risk groups provided the basis identify thresholds recommend screening. Guided thresholds, initiation at 35 years was recommended for men who have sex with (MSM) and transgender women (TW) HIV. For other people HIV MSM TW not HIV, 45 recommended. solid organ transplant recipients, beginning from 10...
Objectives To define minimum standards for provision of services and clinical practice in the investigation anal cancer precursors. Methods After initial face to meetings experts at International Papillomavirus meeting Lisbon, September 17 21, 2015, a first version was drafted sent key stakeholders. A complete draft reviewed by Board Anal Neoplasia Society (IANS) uploaded IANS Web site all members provide comments. The final ratified on June 22, 2016. Results essential components...
Objective Oseltamivir is the only oral neuraminidase inhibitor currently available; we determined tolerability and antiviral efficacy of peramivir for treatment prophylaxis experimental human influenza A B. Participants 288 susceptible, healthy volunteers (ages 18–45) were inoculated intranasally with A/Texas/36/ 91/H1N1 or B/Yamagata/16/88 virus in four randomized, double-blind, placebo-controlled trials. Interventions: For dosing was initiated at 24 h after inoculation doses ranging from...
In June 2019 the Centers for Disease Control and Prevention (CDC) convened an advisory group to assist in development of 2021 CDC sexually transmitted infections (STI) guidelines. The on anal cancer screening prevention met formulate key questions this field. examined published literature abstracts assess evidence give recommendations This article summarizes questions, evidence, recommendations, areas further research screening, diagnosis, cancer.
Women living with human immunodeficiency virus (WLHIV) have disproportionately high rates of squamous cell carcinoma the anus compared general population women. Anal high-grade intraepithelial lesions (HSILs) precede anal cancer, and accurate studies HSIL prevalence among WLHIV in United States are lacking.The AIDS Malignancy Consortium 084 study was a multicenter national trial to evaluate risk factors for US cohort. Eligible participants were aged ≥18 years no history HSIL. Study had an...
Abstract: Background Cryptosporidial enteritis, a diarrheal infection of the small intestine caused by apicomplexan protozoa C ryptosporidium , is infrequently recognized in transplant recipients from developed countries. Methods A retrospective review all cases cryptosporidiosis solid organ ( SOT ) at 2 centers J anuary 2001 to O ctober 2010 was performed and compared with community‐onset lostridium difficile CDI ). literature search regard reported recipients. Results Eight renal, 1 liver,...
Men who have sex with men (MSM) are at high risk for human papillomavirus (HPV)-related anal cancer. Little is known about the prevalence of low-grade squamous intraepithelial lesions (LSILs) and cancer precursor, high-grade (HSILs), among young MSM HIV (MSMLWH). HPV vaccination recommended in this group, but its safety, immunogenicity, protection against vaccine-type infection associated LSILs/HSILs not been studied.Two hundred sixty MSMLWH aged 18-26 years were screened 17 US sites a...
Background: Several artificial intelligence systems based on large language models (LLMs) have been commercially developed, with recent interest in integrating them for clinical questions. Recent versions now include image analysis capacity, but their performance gastroenterology remains untested. This study assesses ChatGPT-4's interpreting images. Methods: A total of 740 images from five procedures-capsule endoscopy (CE), device-assisted enteroscopy (DAE), endoscopic ultrasound (EUS),...
The Anal Cancer/High-grade squamous intraepithelial lesions Outcomes Research (ANCHOR) trial demonstrated that treating precancerous anal HSIL reduces the incidence of cancer by 57% in people with HIV. It remains unclear how treatment or monitoring without affects patient-reported health-related quality life (HRQoL). We evaluated differences HRQoL for individuals who were randomly assigned to active (AM) HSIL. Using an index designed and validated use ANCHOR, was assessed before random...
The aims of this study were to: 1) determine prevalence anogenital and oral HPV, 2) concordance between HPV at anal, perianal, scrotal/penile, sites; 3) describe factors associated with types targeted by the 9-valent vaccine. Data collected from 2012 to 2015 among men who have sex 18–26 years age enrolled in a vaccine trial (N = 145). Penile/scrotal, samples tested for 61 types. Logistic regression was used identify Participants' mean 23.0 years, 55.2% African-American, 26.2% Hispanic; 93%...
Objective: HIV-infected women (WLHIV) have more than 10-fold higher risk for squamous cell cancer of the anus. Experts suggest cytology-based strategies developed cervical screening may prevent anal by detecting cytologic or histological high-grade intraepithelial lesion (hHSIL) treatment. Currently, there is no consensus on anal-hHSIL WLHIV. Design: Between 2014 and 2016, 276 WLHIV were recruited at 12 US AIDS Malignancy Consortium clinical trials sites to evaluate hHSIL prevalence (test)...
The incidence of anal cancer is increasing in the general population and especially high-risk groups. A total 90% cancers are caused by human papilloma virus (HPV) infection canal. Similar to cervical cancer, progresses through a predictable series premalignant stages before resulting invasive cancer; this process begins with persistent HPV infection. vaccine represents promising strategy combat cancer. Human Immunodeficiency Virus (HIV) predisposes people infection, dysplasia, subsequent...
Abstract Nephrotoxicity is a significant concern during the development of new drugs or when assessing safety chemicals in consumer products. Traditional methods for testing nephrotoxicity involve animal models 2D vitro cell cultures, latter which lack complexity and functionality human kidney. 3D are created by culturing primary kidney cells derived from urine microenvironment that mimics fluid shear stresses Thus, provide more accurate reliable predictions compared to existing models. In...
Women living with HIV (WLWH) experience high rates of anal cancer. Screening using cytology, high-resolution anoscopy (HRA) biopsies, can histologically diagnose cancer precursors called high-grade squamous intraepithelial lesions (HSIL). The low specificity screening cytology results in HRA referral for many WLWH without HSIL. high-risk human papillomavirus (HR-HPV) may improve specificity.
A 29-year-old female presented with chronic postpartum abdominal pain. Computerized tomography scan was consistent ovarian carcinoma, and biopsy yielded macrophages laden eosinophilic bodies. Cultures, histoplasma serologies, taxoplasma serologies were negative. diagnosis of pelvic donovanosis reached; the patient treated azithromycin resulting in clinical radiographic resolution.
Persistent human papillomavirus infection in immunodeficiency virus (HIV)-infected individuals has been strongly associated with anal squamous cell carcinoma. The incidence of carcinoma continues to increase this population despite advances HIV therapy. There are few studies describing the prevalence cancer precursors, treatment outcomes, and factors among HIV-infected populations southern United States.A retrospective chart review was performed on 355 patients from a Southern clinic who...
Although cystic echinococcus (CE) is a common disorder worldwide, few cases are treated in the United States and other industrialized countries. Migration tourism have caused an increase incidence of this parasitic infection countries, physicians must be familiar with its management.We report successful therapy CE immigrant from Afghanistan.The patient presented large epigastric mass that was initially misdiagnosed as gastric gastrointestinal stromal tumor. The removed, together partial...